The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma.

Abstract:

BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma. METHODS:In the current study, Fhit expression was examined in invasive carcinomas and in epithelial lesions representing stages of carcinoma progression in 50 mastectomy specimens using immunohistochemical methods. RESULTS:Normal ductal and lobular epithelium consistently and strongly expressed Fhit. A complete loss of or a significant reduction in Fhit expression was observed in 72% of breast carcinomas. A statistically significant, negative correlation in Fhit expression among the stages of disease progression in Fhit negative breast carcinomas was observed (normal epithelium > hyperplasia > atypical hyperplasia and carcinoma in situ > invasive carcinoma), whereas no loss of Fhit expression in precursor lesions was observed in Fhit positive tumors. CONCLUSIONS:These observations are consistent with the observed role of FHIT as a tumor suppressor gene in the pathogenesis of specific subsets of carcinomas.

journal_name

Cancer

journal_title

Cancer

authors

Gatalica Z,Lele SM,Rampy BA,Norris BA

subject

Has Abstract

pub_date

2000-03-15 00:00:00

pages

1378-83

issue

6

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(20000315)88:6<1378::AID-CN

journal_volume

88

pub_type

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