Abstract:
:Traditional therapy for malignant pleural effusions includes thoracentesis or tube drainage with instillation of irritants to achieve pleurodesis. This can require a lengthy hospitalization, causes pain and discomfort, and has an appreciable failure rate. Because of these drawbacks, the authors used a shunting device to transfer fluid to the peritoneal cavity in 17 patients with malignant pleural effusions. Eleven patients had undergone previous therapeutic thoracenteses and three had chest tube placement with failed sclerosis. The shunt was a subcutaneous valved pump chamber with attached pleural and peritoneal catheters, which used manual compression to transfer fluid against the normal abdominal/pleural pressure gradient. Operative placement under local or general anesthesia was performed without complication. Five patients achieved minimal benefit, either because of moribund status or their inability to compress the pump effectively. In the other 12 patients, there was radiographic evidence of diminished or stabilized pleural effusion; respiratory symptoms were effectively palliated, and no further treatment for their effusion was required. Peritoneal dissemination of malignant cells has not been clinically detected. We feel that pleuroperitoneal shunting is a valid new method for treatment of malignant pleural effusions which can effectively palliate respiratory symptoms with low morbidity. Advantages include the absence of external tubing and the possibility for only a short hospitalization or even outpatient placement. Shunting is applicable for patients who are able to perform the requisite pumping and is particularly suitable for those with trapped lungs or who have failed attempted pleural sclerosis.
journal_name
Cancerjournal_title
Cancerauthors
Little AG,Ferguson MK,Golomb HM,Hoffman PC,Vogelzang NJ,Skinner DBdoi
10.1002/1097-0142(19861215)58:12<2740::aid-cncr282subject
Has Abstractpub_date
1986-12-15 00:00:00pages
2740-3issue
12eissn
0008-543Xissn
1097-0142journal_volume
58pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Activation of telomerase, a ribonucleoprotein enzyme complex that synthesizes telomere repeats, is associated with acquisition of unlimited cellular proliferation and is commonly detected in human cancer. Measurement of telomerase activity (TA) may provide important information as a diagnostic marker or a pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000315)88:6<1304::aid-cn
更新日期:2000-03-15 00:00:00
abstract:BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30881
更新日期:2017-12-15 00:00:00
abstract::Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) origin. Twenty of the primary and two of the metastatic carcinoi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<68::aid-cncr282049
更新日期:1982-01-01 00:00:00
abstract::The introduction of trimodal combination therapy (surgery + radiation + intraarterial infusion) for maxillary carcinoma resulted in a change in the sites of recurrence and no satisfactory improvement in the local control rate. To examine the cause of these phenomena, external carotid angiography was performed on 51 pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821215)50:12<2790::aid-cncr282
更新日期:1982-12-15 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28019
更新日期:2013-06-01 00:00:00
abstract::Between September 21, 1973 and May 9, 1975, 36 patients with metastatic cervical adenopathy from cancers primarily arising in the pharynx or oral cavity, including six with bilateral cervical involvement, received fast neutron teletherapy at the University of Washington. At the conclusion of treatment, the masses were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197606)37:6<2613::aid-cncr282037
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:Achieving a pathologic complete response (pCR) with neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC) has been associated with improved overall survival (OS). This study was aimed at evaluating the impact of pathologic downstaging (pDS; ie, a pT stage at least 1 stage lowe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32169
更新日期:2019-09-15 00:00:00
abstract:BACKGROUND:Poor prognosis of Stage IV breast cancer patients have at best a 10% 3-year survival rate with conventional chemotherapy. Dose-intensive chemotherapy improved survival rates for some of these patients. METHODS:All patients were Stage IV estrogen receptor-negative or estrogen receptor-positive hormonal refra...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19940415)73:8<2157::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with gastrointestinal stromal tumors (GISTs), but most patients eventually develop resistance and progress. Dasatinib is a potent inhibitor of BCR-ABL, KIT, and SRC family kinases as well as imatinib-resistant cells. In GISTs, response e...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31234
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Re...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.20756
更新日期:2005-01-15 00:00:00
abstract::The responses of 23 patients with agnogenic myeloid metaplasia (AMM) to androgen therapy were studied. Various clinical and laboratory parameters were analyzed for their value in determining response to therapy and length of survival. Fifty-seven percent of patients responded, as determined by a sustained increase in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820115)49:2<308::aid-cncr28204
更新日期:1982-01-15 00:00:00
abstract:BACKGROUND:Immunophenotypic analysis is an established tool in the diagnosis and classification of many hematolymphoid disorders; however, the role of flow cytometry (FC) in detecting bone marrow involvement during the staging of non-Hodgkin lymphoma (NHL) has yet to be defined. METHODS:The authors retrospectively ana...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:To evaluate the pathologic characteristics of the primary tumor relative to local control, survival, and freedom from distant metastases, an analysis was performed of 172 patients with ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive breast ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19930415)71:8<2532::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract::Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistical...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<666::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920401)69:7<1865::aid-cncr2820
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma. METHODS:Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institution...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21169
更新日期:2005-07-01 00:00:00
abstract::Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia. Thymic carcinomas may metastasize outside of the thorax and are associated with a very poor prognosis. Complete responses of thymic carcinoma to chemotherapy a...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:10.1002/1097-0142(19901115)66:10<2092::aid-cncr282
更新日期:1990-11-15 00:00:00
abstract:BACKGROUND:Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11482
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pharmacokinetics (PK). METHODS:Patients had evidence of epidermal growth factor receptor (EGFR) expression (> o...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.24148
更新日期:2009-04-15 00:00:00
abstract:BACKGROUND:To determine whether high-risk patients with hematuria receive evaluation according to guideline recommendations. METHODS:We recently performed a screening study for bladder cancer using a urine-based tumor marker in 1502 subjects at high risk based on aged > or = 50 years, > or = 10-year smoking history, a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25048
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:High mobility group AT-hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. The authors hypothesized that tumor HMGA1 status represents a novel prognostic marker in pancreatic adenocarcinoma. They also tested the hypothesis that HMGA1 promotes ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23560
更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:Myoepithelial carcinoma, also know as malignant myoepithelioma, is rare in the salivary gland, and its cytologic features have rarely been reported. DESIGN:Four cases of myoepithelial carcinoma with cytology were retrieved from the archives of the Pathology Departments of two academic institutes. In three c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-25 00:00:00
abstract::Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840715)54:2<274::aid-cncr28205
更新日期:1984-07-15 00:00:00
abstract::Flow cytometry (FC) analysis including DNA index (ploidy status) and cell kinetics (%S and %S + G2/M) was done on frozen tissue of the primary lesions of 101 women with node negative (N-) breast cancer who were studied prospectively. Currently, 19% (19/101) of the patients have recurred. No significant relations have ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891101)64:9<1894::aid-cncr2820
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Cancer clinicians do not receive routine training in the psychosocial aspects of patient care such as how to communicate bad news or respond to patients who have unrealistic expectations of cure. Postgraduate workshops may be an effective way to increase interpersonal skills in managing these stressful patie...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Health systems in Sub-Saharan Africa are not prepared for the rapid rise in cancer rates projected in the region over the next decades. More must be understood about the current state of cancer care in this region to target improvement efforts. Yaounde General Hospital (YGH) currently is the only site in Cam...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26681
更新日期:2012-07-15 00:00:00
abstract:BACKGROUND:In many areas of health care, whether patients receive specific medical interventions often is influenced heavily by the local availability of resources for delivering those services. However, relations between resource availability and utilization are relatively unexplored in cancer care, including perioper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22458
更新日期:2007-02-15 00:00:00
abstract::One hundred eighty-nine patients received a four-drug combination consisting of cyclophosphamide, Oncovin (vincristine), methyl CCNU, and bleomycin (COMB), according to three different drug regimens, performed sequentially. Of the 189, 62 had a partial response (33%) including 11/33 with squamous lung cancer, 11/32 wi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2<327::aid-cncr2820360
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. However, whether a predominant insular component is an independent factor for poor prognosis is unclear. METHODS:The authors compared the clinical behavior of tumors in three groups of patients with thyroid carcinoma--13...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10947
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:It is unclear whether patients with Stage II colon carcinoma should be offered adjuvant chemotherapy. Therefore, the authors analyzed the risk factors of these patients to identify high-risk subgroups who may benefit from such treatment. METHODS:The data from 305 patients with Stage II colon carcinoma docum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1435::aid-cncr1467
更新日期:2001-09-15 00:00:00