Abstract:
:Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas stained positive for thyroglobulin; 14 of the 23 undifferentiated carcinomas showed only a focal and weak reaction for thyroglobulin. The metastases showed the same reaction pattern as the primary lesion. Calcitonin was present only in the medullary carcinomas and in 2 of the 23 undifferentiated carcinomas. Carcinoembryonic antigen was not present frequently in the investigated carcinomas. The reliability of the method, its clinical importance, and the possibilities it offers for a more precise classification are discussed. The diagnostic value of the method is illustrated by two case reports.
journal_name
Cancerjournal_title
Cancerauthors
Logmans SC,Jöbsis ACdoi
10.1002/1097-0142(19840715)54:2<274::aid-cncr28205subject
Has Abstractpub_date
1984-07-15 00:00:00pages
274-9issue
2eissn
0008-543Xissn
1097-0142journal_volume
54pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The specific volatile organic compounds (VOCs) exhaled by lung cancer cells in the microenvironment are the source biomarkers of lung cancer and also serve as direct evidence that the diagnosis of lung cancer by breath is possible. However, to the authors' knowledge, few articles published to date have provi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22844
更新日期:2007-08-15 00:00:00
abstract::Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4<700::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract:BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32392
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RES...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(20000515)88:10<2367::aid-c
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord-sparing reirradiation of spinal metastases and tumors. METHODS:Thirty-six patients with spinal metastases and tumors who had undergone previous radiotherapy were reirradiated with hel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25187
更新日期:2010-08-15 00:00:00
abstract:BACKGROUND:The purpose of this project was to develop the M. D. Anderson Symptom Inventory (MDASI), a brief measure of the severity and impact of cancer-related symptoms. METHODS:A list of symptoms was generated from symptom inventories and by panels of clinicians. Twenty-six symptoms and 6 interference items were rat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001001)89:7<1634::aid-cncr29>3
更新日期:2000-10-01 00:00:00
abstract::The value of the serum level of carcinoembryonic antigen (CEA) as an indicator of recurrent colorectal carcinoma has been accepted, and the use of serial CEA levels to monitor postoperative chemotherapy has been suggested, However, elevated CEA levels may be associated with nonneoplastic conditions, of which the most ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810201)47:3<481::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chemotherapy, more recent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25298
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS:Computed tomography (CT) scans before and after therapy were reviewed in 4...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31251
更新日期:2018-04-15 00:00:00
abstract:BACKGROUND:Methotrexate is readily absorbed from the intestinal tract. When given to patients with urinary diversion to the intestinal tract, methotrexate may be reabsorbed into the circulation, thus increasing its serum concentration and potentially increasing its toxicity. METHODS:Forty-eight patients with transitio...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-15 00:00:00
abstract:BACKGROUND:Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-08-25 00:00:00
abstract::Twenty-two children with acute lymphocytic leukemia (ALL) who had relapsed while on therapy and for whom remissions were successfully reinduced were maintained with a combination of methotrexate, daunomycin, 6-mercaptopurine, prednisone, and vincristine (Djerassi-methotrexate with BOMB). The median duration of remissi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800901)46:5<1093::aid-cncr2820
更新日期:1980-09-01 00:00:00
abstract::A 42-year-old woman developed lower extremity weakness and sensory loss 1 year after external and intracavitary radiotherapy for Stage IB carcinoma of cervix. She has been followed for 5 years posttreatment, and the neurologic abnormalities have persisted, but no evidence of recurrent carcinoma has been found. We beli...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901001)66:7<1488::aid-cncr2820
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990501)85:9<2073::aid-cn
更新日期:1999-05-01 00:00:00
abstract::The use of preoperative computed tomographic (CT) scans of the chest in carcinoma of the esophagus to associate preoperative staging with postoperative survival is controversial. Thirty-two patients who underwent esophagectomy and reconstruction were examined with respect to a variety of variables available on preoper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1287::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract::The records of 98 children with suprasellar tumors treated between 1950 and 1975, at Columbia-Presbyterian Medical Center, were reviewed. Most of the children with germ cell tumors or posterior chiasmal gliomas irradiated with 5000 rad in six weeks using extended field, children with craniopharyngiomas treated with to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821001)50:7<1420::aid-cncr2820
更新日期:1982-10-01 00:00:00
abstract::Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860315)57:6<1092::aid-cncr2820
更新日期:1986-03-15 00:00:00
abstract:BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940201)73:3+<850::aid-cncr2820
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:There are large geographic gradients in mortality rates for a number of cancers in the U.S. (e.g., rates are approximately twice as high in the northeast compared with the southwest). Risk factors such as diet fail to explain this variation. Previous studies have demonstrated that the geographic distribution...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10427
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32557
更新日期:2020-02-01 00:00:00
abstract::Retinoblastoma should not be considered as the exceptional childhood cancer that shows dominant inheritance, but rather as the typical childhood cancer that embraces a prezygotic and postzygotic subgroup. Postzygotic cases are conceived as involving mutation as a first step too, but with the mutation in somatic rather...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<1022::aid-cncr28203
更新日期:1975-03-01 00:00:00
abstract::A number of problems inherent to quality of care evaluation have been described above. Although issues such as limited resources and clinical staff resistance may not be specific to cancer care, they certainly impact on the evaluation of the quality of care offered to cancer patients. Other issues such as complexity o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1+<302::aid-cncr2820
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤ 60 years old. METHODS:Between August 2006 and January 2010, 262 hormone-naive men ≤ 60 years old were treated with definitive proton therapy for prostate cancer. Before treatme...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27398
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:High rates of locoregional recurrence have been reported from surgical series of locally advanced melanoma. In this study, the outcomes of patients treated with surgery and postoperative hypofractionated radiation therapy were reviewed to assess local recurrence and survival. METHODS:From 1989 to 1998, 174 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000101)88:1<88::aid-cncr
更新日期:2000-01-01 00:00:00
abstract::The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26098
更新日期:2011-11-01 00:00:00
abstract::The authors investigated the ability of androgen receptor binding in prostate cancer tissue to predict the response of prostate cancer patients to endocrine therapy. The clinical response of 37 previously untreated patients with various grades and stages of prostate cancer was correlated with androgen receptor binding...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870501)59:9<1599::aid-cncr2820
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Amplification of the N-myc oncogene is associated with adverse outcomes in the common childhood tumor, neuroblastoma. Because the transforming properties of Myc are related to its ability to modulate gene expression, the authors used cDNA microarrays to identify potential Myc target genes. METHODS:Expressio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11584
更新日期:2003-08-15 00:00:00
abstract::The myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are malignancies that frequently harbor the recurrent somatic point mutation JAK2(V617F). The discovery of this mutation has fueled the development of Janus kinase 2 (JAK2) inhibitors. Availab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26359
更新日期:2012-02-15 00:00:00
abstract::In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of pr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197507)36:1<123::aid-cncr2820360
更新日期:1975-07-01 00:00:00