Abstract:
:The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rosen schedule, or elective bilateral lung irradiation of 20 Gy, or 3 months of chemotherapy followed by lung irradiation. The 4-year disease-free survival and total survival were 24% and 43%, respectively, with no difference between the treatment arms. In the radiotherapy arms the lung metastases were more frequently suitable for surgical treatment. The survival of patients with either tibia localizations or higher age was somewhat better. Local recurrences occurred in 16% of patients, 50% of them with distant metastases. The trial was executed from 1978 to 1983; 205 patients were evaluable and eligible, and three toxic deaths occurred in the chemotherapy arms. Elective lung irradiation provided the same survival as the adjuvant chemotherapy given in that time.
journal_name
Cancerjournal_title
Cancerauthors
Burgers JM,van Glabbeke M,Busson A,Cohen P,Mazabraud AR,Abbatucci JS,Kalifa C,Tubiana M,Lemerle JS,Voûte PAdoi
10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820subject
Has Abstract,Author List Incompletepub_date
1988-03-01 00:00:00pages
1024-31issue
5eissn
0008-543Xissn
1097-0142journal_volume
61pub_type
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