Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure.

Abstract:

:Between March 1973, and December 1976, 22 patients who developed disease progression during or after MOPP therapy were treated with a new combination, B-CAVe (Bleomycin 5 mg/m2 iv days 1, 28, 35; CCNU 100 mg/m2 po day 1; adriamycin 60 mg/m2 iv day 1; and vinblastine 5 mg/m2 iv day 1). Objective responses were achieved in 17 of 22 patients (77%) and 11 of 22 responses were complete (50%). The actuarial survival for all patients is 16.4 months. For complete responders the median is 24 months with 2 complete responders dead without evidence of Hodgkin's Disease. Median relapse free survival for complete responders has not been reached at 35+ months while that for partial responders is 14 months. Significant adriamycin cardiotoxicity was encountered in two patients. There were no life threatening bacterial infections during B-CAVe. Two patients died of Pneumocystis carinii several months after cessation of therapy. B-CAVe is effective in the therapy of advanced Hodgkin's disease after MOPP failure, and this regimen is comparable to other previously reported MOPP salvage combinations.

journal_name

Cancer

journal_title

Cancer

authors

Porzig KJ,Portlock CS,Robertson A,Rosenberg SA

doi

10.1002/1097-0142(197805)41:5<1670::aid-cncr282041

subject

Has Abstract

pub_date

1978-05-01 00:00:00

pages

1670-5

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

41

pub_type

杂志文章

相关文献

CANCER文献大全
  • Surgery for colorectal carcinoma.

    abstract::An adequate operation for colorectal carcinoma involves removal of the primary tumor and wide excision of the mesentery with its contained regional lymph nodes and lymphovascular pathways. Enker and DeCosse state that radical resection, i.e., total mesenteric lymphadenectomy encompassing the origins of the complete ar...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830615)51:12+<2525::aid-cncr28

    authors: Leffall LD Jr

    更新日期:1983-06-15 00:00:00

  • Esophageal dilation in malignant dysphagia.

    abstract::Esophageal dilation by means of guided Neoplex (Medoc) tubes in 38 patients with malignant obstruction of the esophagus was analyzed. Peroral dilation proved to be a simple, well-tolerated primary procedure in the management of malignant strictures. Most patients have a temporary improvement of dysphagic symptoms, but...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2713::aid-cncr282

    authors: Aste H,Munizzi F,Martines H,Pugliese V

    更新日期:1985-12-01 00:00:00

  • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system.

    abstract:BACKGROUND:An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum EGFR scoring system. METHODS:Tissue sections from 102 patients with T3N1-2M1 colon adenocarcino...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010901)92:5<1331::aid-cncr1455

    authors: Goldstein NS,Armin M

    更新日期:2001-09-01 00:00:00

  • General population norms for the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI).

    abstract:BACKGROUND:Metastatic renal cell cancer is associated with poor long-term survival and has no cure. Traditional clinical endpoints are best supplemented by patient-reported outcomes designed to assess symptoms and function. Normative data was obtained on the National Comprehensive Cancer Network-Functional Assessment o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27688

    authors: Butt Z,Peipert J,Webster K,Chen C,Cella D

    更新日期:2013-01-15 00:00:00

  • Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma.

    abstract:BACKGROUND:Optimal treatments for vulvar and vaginal melanomas (VVMs) have not been identified. Herein, the authors compare molecular profiles between VVM and nongynecologic melanoma (NGM) subtypes with the objective of identifying novel, targetable biomarkers. METHODS:In total, 2304 samples of malignant melanoma that...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30473

    authors: Hou JY,Baptiste C,Hombalegowda RB,Tergas AI,Feldman R,Jones NL,Chatterjee-Paer S,Bus-Kwolfski A,Wright JD,Burke WM

    更新日期:2017-04-15 00:00:00

  • Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery.

    abstract:BACKGROUND:Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma. METHODS:Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.2 to 23.8 years (median, 3.3 yrs). All living...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21038

    authors: Mendenhall WM,Morris CG,Amdur RJ,Werning JW,Villaret DB

    更新日期:2005-06-01 00:00:00

  • Stratification of risk factors in renal cell carcinoma.

    abstract::One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830901)52:5<899::aid-cncr28205

    authors: Selli C,Hinshaw WM,Woodard BH,Paulson DF

    更新日期:1983-09-01 00:00:00

  • Prognostic factors in male urethral cancer.

    abstract:BACKGROUND:Male urethral cancer is a rare neoplasm, with the published literature consisting of small single-institution retrospective series. As such, there is no objective analysis of prognostic factors and treatment outcome. The author sought to use the population-based Surveillance, Epidemiology, and End Results (S...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25787

    authors: Rabbani F

    更新日期:2011-06-01 00:00:00

  • Chemotherapy followed by lung resection in inoperable non-small cell lung carcinomas due to locally far-advanced disease.

    abstract::From 1977, 29 patients with inoperable non-small cell lung carcinoma due to locally far-advanced disease underwent lung resection after receiving two to eight courses of chemotherapy. After the surgery was performed, three additional courses of chemotherapy were given. The overall median survival from onset of the che...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860201)57:3<630::aid-cncr28205

    authors: Takita H,Regal AM,Antkowiak JG,Rao UN,Botsoglou NK,Lane WW

    更新日期:1986-02-01 00:00:00

  • Aberrant, highly hyperdiploid cells in human papillomavirus-positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix.

    abstract:BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20848

    authors: Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

    更新日期:2005-04-25 00:00:00

  • Radiation oncology: cancer of the prostate.

    abstract::The role of palliative radiation treatment of prostate cancer is well recognized. Appreciation of the value of definitive radiation therapy in management of locally advanced prostate cancer is increasing. Optimal management requires careful patient selection with multidiscipline evaluation to provide accurate grading ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2+<856::aid-cncr282039

    authors: Taylor WJ

    更新日期:1977-02-01 00:00:00

  • Radioimmunoassay for plasma glutathione S-transferase-pi and its clinical application in gastrointestinal cancer.

    abstract:BACKGROUND:Plasma acidic glutathione S-transferase (GST-pi) concentrations in 135 patients with gastrointestinal cancer were measured by an improved radioimmunoassay (RIA). METHODS:Blood was collected into a silicified glass tube containing a specific anticoagulant. The plasma, which was separated rapidly by centrifug...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951015)76:8<1363::aid-cncr2820

    authors: Fan KC,Huang YC,Li CH

    更新日期:1995-10-15 00:00:00

  • Lung cancer as a second primary.

    abstract::An unusually high association of other primary cancers (9.7%) was found during the analysis of 403 consecutive cases of carcinoma of the lung diagnosed at DGMC between 1960 and 1975. Incidence by stage included 17.3% for Stage I (75 cases) and 16.9% for Stage II (59 cases). Median survival by stage was not adversely a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197812)42:6<2887::aid-cncr282042

    authors: Reynolds RD,Pajak TF,Greenberg BR,Shirley JH,Lucas RN,Hill RP,Schacht LR

    更新日期:1978-12-01 00:00:00

  • Spontaneously regressing adrenocortical carcinoma in a newborn. A case report with DNA ploidy analysis.

    abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880801)62:3<507::aid-cncr28206

    authors: Saracco S,Abramowsky C,Taylor S,Silverman RA,Berman BW

    更新日期:1988-08-01 00:00:00

  • Elevation of serum levels of matrix metalloproteinase-2 and -3 as new predictors of recurrence in patients with urothelial carcinoma.

    abstract:BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Gohji K,Fujimoto N,Komiyama T,Fujii A,Ohkawa J,Kamidono S,Nakajima M

    更新日期:1996-12-01 00:00:00

  • Fibronectin patterns in hepatocellular carcinoma and its clinical significance.

    abstract::Fibronectin, a high molecular weight glycoprotein component of the extracellular matrix, was localized extracellularly and intracellularly in the nuclei and the cytoplasm of hepatocellular carcinomas (HCC) by the use of the biotin-avidin method on paraffin-embedded, pepsin-treated tissue. The specificity of the staini...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851001)56:7<1643::aid-cncr2820

    authors: Jagirdar J,Ishak KG,Colombo M,Brambilla C,Paronetto F

    更新日期:1985-10-01 00:00:00

  • Coordinate elevation of serum markers in ovarian cancer but not in benign disease.

    abstract::Effective screening for occult ovarian cancer will require a strategy that is both sensitive and specific. Preliminary data suggest that CA 125 is elevated at diagnosis in a majority of patients with ovarian cancer. Although CA 125 is sufficiently specific to prompt its evaluation as one component of a strategy to det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911015)68:8<1758::aid-cncr2820

    authors: Bast RC Jr,Knauf S,Epenetos A,Dhokia B,Daly L,Tanner M,Soper J,Creasman W,Gall S,Knapp RC

    更新日期:1991-10-15 00:00:00

  • Malignant large cell lymphoma of B-cell type with multilobated nuclei. Report of a case and review of the literature.

    abstract::Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9<1913::aid-cncr2820

    authors: Parfrey NA,Mann RB,Selonick SE,Beschorner WE

    更新日期:1985-05-01 00:00:00

  • Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.

    abstract::Doxorubicin has been reported to cause ventricular arrhythmias and sudden death in the first 24 hours after administration. The authors placed continuous electrocardiographic recording devices on 30 patients 24 hours before, during, and 24 hours after doxorubicin administration. Nine patients experienced arrhythmias b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851215)56:12<2762::aid-cncr282

    authors: Friess GG,Boyd JF,Geer MR,Garcia JC

    更新日期:1985-12-15 00:00:00

  • Meaningful endpoints for therapies approved for hematologic malignancies.

    abstract:BACKGROUND:Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30622

    authors: Smith BD,DeZern AE,Bastian AW,Durie BGM

    更新日期:2017-05-15 00:00:00

  • Bone sarcomas associated with Ollier's disease.

    abstract::Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820

    authors: Liu J,Hudkins PG,Swee RG,Unni KK

    更新日期:1987-04-01 00:00:00

  • Hormone replacement therapy and lung cancer risk in Chinese.

    abstract:BACKGROUND:The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies. There is a high female to male ratio in Chinese lung cancer patients, and female patients have different clinicopathological characteristics compared with Western patient population...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22987

    authors: Chen KY,Hsiao CF,Chang GC,Tsai YH,Su WC,Perng RP,Huang MS,Hsiung CA,Chen CJ,Yang PC,GEFLAC Study Group.

    更新日期:2007-10-15 00:00:00

  • Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal.

    abstract:BACKGROUND:The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (IMRT) or conventional radiotherapy (CRT). METHODS:Forty-six patients who received definitive chemor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25901

    authors: Bazan JG,Hara W,Hsu A,Kunz PA,Ford J,Fisher GA,Welton ML,Shelton A,Kapp DS,Koong AC,Goodman KA,Chang DT

    更新日期:2011-08-01 00:00:00

  • Clear cell sarcoma. A clinicopathologic study of 27 cases.

    abstract::Clear cell sarcoma is an indolent tumor of uncertain histogenesis. Twenty-seven patients ranging in age from 9 to 57 years (average, 28.5 years) were followed an average of 7.0 years. Females outnumbered males by 2 to 1. Distal extremity locations predominated. At presentation, the tumor was localized in 21 patients, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831015)52:8<1482::aid-cncr2820

    authors: Eckardt JJ,Pritchard DJ,Soule EH

    更新日期:1983-10-15 00:00:00

  • Smoking status and survival in the national comprehensive cancer network non-small cell lung cancer cohort.

    abstract:BACKGROUND:The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non-small cell lung cancer (NSCLC). METHODS:The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, form...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27824

    authors: Ferketich AK,Niland JC,Mamet R,Zornosa C,D'Amico TA,Ettinger DS,Kalemkerian GP,Pisters KM,Reid ME,Otterson GA

    更新日期:2013-02-15 00:00:00

  • Atypical fibroxanthoma of the skin with metastasis.

    abstract::Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulcernodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860115)57:2<368::aid-cncr28205

    authors: Helwig EB,May D

    更新日期:1986-01-15 00:00:00

  • Castleman's disease in POEMS syndrome with elevated interleukin-6.

    abstract::POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920601)69:11<2697::aid-cncr282

    authors: Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

    更新日期:1992-06-01 00:00:00

  • Reduced-intensity conditioning with fludarabine and busulfan versus fludarabine and melphalan for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

    abstract:BACKGROUND:Fludarabine plus busulfan (FB) and fludarabine plus melphalan (FM) are 2 widely used reduced-intensity conditioning (RIC) regimens for allogeneic hematopoietic stem cell transplantation (allo-SCT). METHODS:The current survey compared transplantation outcomes for a cohort of 394 acute myeloid leukemia (AML) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29163

    authors: Baron F,Labopin M,Peniket A,Jindra P,Afanasyev B,Sanz MA,Deconinck E,Nagler A,Mohty M

    更新日期:2015-04-01 00:00:00

  • Noninvasive radiofrequency treatment effect on mitochondria in pancreatic cancer cells.

    abstract:BACKGROUND:The development of novel therapeutic approaches for cancer therapy is important, especially for tumors that have poor response or develop resistance to standard chemotherapy and radiation. We discovered that noninvasive radiofrequency (RF) fields can affect cancer cells but not normal cells, inhibit progress...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28895

    authors: Curley SA,Palalon F,Lu X,Koshkina NV

    更新日期:2014-11-01 00:00:00

  • Small cell carcinoma of the major salivary glands.

    abstract::Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860801)58:3<705::aid-cncr28205

    authors: Gnepp DR,Corio RL,Brannon RB

    更新日期:1986-08-01 00:00:00