Vascular-targeting therapies for treatment of malignant disease.

abstract：BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...

journal_title：Cancer

authors： Cassier PA,Gelderblom H,Stacchiotti S,Thomas D,Maki RG,Kroep JR,van der Graaf WT,Italiano A,Seddon B,Dômont J,Bompas E,Wagner AJ,Blay JY

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:It is believed that in the early stages of hepatocarcinogenesis, some adenomatous hyperplasias (AH) progress to early hepatocellular carcinoma (eHCC), and that many eHCC develop into overt hepatocellular carcinoma (HCC) through nodule-in-nodule formation. However, the proliferative activity of these small no...

journal_title：Cancer

authors： Aoki K,Sakamoto M,Hirohashi S

更新日期：1994-01-15 00:00:00

abstract：BACKGROUND:There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. METHODS:A broad...

journal_title：Cancer

authors： Freund KM,Haas JS,Lemon SC,Burns White K,Casanova N,Dominici LS,Erban JK,Freedman RA,James TA,Ko NY,LeClair AM,Moy B,Parsons SK,Battaglia TA

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:The purpose of the study was to determine the utility of quantitation of the extracellular domain (ECD) of the HER-2/neu receptor in the serum for predicting response to treatment in patients with primary breast cancer receiving neoadjuvant therapy. METHODS:HER-2/neu ECD was measured in sera obtained from 3...

journal_title：Cancer

authors： Mazouni C,Hall A,Broglio K,Fritsche H,Andre F,Esteva FJ,Hortobagyi GN,Buzdar AU,Pusztai L,Cristofanilli M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant...

journal_title：Cancer

authors： Gatalica Z,Lele SM,Rampy BA,Norris BA

更新日期：2000-03-15 00:00:00

abstract：:Carcinoma of the large bowel is rare in persons under the age of 30, and generally presents with advanced stages of disease. From 1964 to 1984, 30 patients presented with nonfamilial large bowel malignancies. Seventeen patients were male, and 13 female (age range, 8-25 years). In 15 patients the primary was in the rig...

journal_title：Cancer

authors： Rao BN,Pratt CB,Fleming ID,Dilawari RA,Green AA,Austin BA

更新日期：1985-03-15 00:00:00

abstract：BACKGROUND:In many areas of health care, whether patients receive specific medical interventions often is influenced heavily by the local availability of resources for delivering those services. However, relations between resource availability and utilization are relatively unexplored in cancer care, including perioper...

journal_title：Cancer

authors： Wong SL,Wei Y,Birkmeyer JD

更新日期：2007-02-15 00:00:00

abstract：BACKGROUND:Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize; however, to the authors' knowledge there are limited data regarding the spread of disease through cerebrospinal fluid (CSF). METHODS:Eight of 200 consecutive patients (4%) with meningiomas...

journal_title：Cancer

authors： Chamberlain MC,Glantz MJ

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The authors' goal was to characterize hospice enrollment and aggressiveness of care for pancreatic cancer patients at the end of life. METHODS:Surveillance, Epidemiology, and End Results and linked Medicare claims data (1992-2006) were used to identify patients with pancreatic cancer who had died (n = 22,81...

journal_title：Cancer

authors： Sheffield KM,Boyd CA,Benarroch-Gampel J,Kuo YF,Cooksley CD,Riall TS

更新日期：2011-11-01 00:00:00

abstract：:During the period from March 1963 through March 1978, 30 patients with malignant neoplasms of the paranasal sinuses were treated with supervoltage technique at the University of Rochester Medical Center. Twenty-one patients had at least the medial portion of the orbit within the effective treatment volume and the rest...

journal_title：Cancer

authors： Nakissa N,Rubin P,Strohl R,Keys H

更新日期：1983-03-15 00:00:00

abstract：BACKGROUND:Primary and metastatic malignancies that originate in the sinonasal tract are rare and histologically diverse. The role of fine-needle aspiration biopsy (FNAB) and the cytomorphologic features of these tumors have not been specifically addressed. METHODS:The authors reviewed 22 cytology cases (20 FNABs, 1 s...

journal_title：Cancer

authors： Helsel JC,Bardales RH,Mukunyadzi P

更新日期：2003-04-25 00:00:00

abstract：BACKGROUND:There is accumulating evidence that galanin receptors (GALRs) may be tumor suppressors in head and neck squamous cell carcinoma (HNSCC). Promoter methylation status and gene expression were assessed in a large panel of head and neck primary tumors, based on the hypothesis that cytosine-guanine dinucleotide (...

journal_title：Cancer

authors： Misawa Y,Misawa K,Kanazawa T,Uehara T,Endo S,Mochizuki D,Yamatodani T,Carey TE,Mineta H

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...

journal_title：Cancer

authors： Tsimberidou AM,Giles F,Duvic M,Fayad L,Kurzrock R

更新日期：2004-01-15 00:00:00

abstract：:Computed tomography (CT) has emerged from the 1980s to play a dominant role in the pretreatment staging of renal and adrenal carcinomas. For detection, definition (staging), and determination of resectability or recurrence, CT with intravenous contrast enhancement, and more recently, magnetic resonance imaging (MRI) w...

journal_title：Cancer

authors： McClennan BL

更新日期：1991-02-15 00:00:00

abstract：:A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...

journal_title：Cancer

authors： Scheithauer BW,Randall RV,Laws ER Jr,Kovacs KT,Horvath E,Whitaker MD

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...

journal_title：Cancer

authors： Cocconi G,Di Blasio B,Boni C,Bisagni G,Ceci G,Rondini E,Bella M,Leonardi F,Savoldi L,Camisa R,Bruzzi P

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:Epstein-Barr virus (EBV) infection has been implicated in the pathogenesis of certain subtypes of salivary gland tumors in the adult population. However, to the authors' knowledge its role in pediatric salivary gland tumors, a rare disease, has not been explored previously. METHODS:Thirteen cases of primary...

journal_title：Cancer

authors： Venkateswaran L,Gan YJ,Sixbey JW,Santana VM

更新日期：2000-07-15 00:00:00

abstract：:Pleural fluid and serum protein electrophoresis and quantitative immunoglobulin measurements were carried out in patients with pleural effusions. The mean pleural fluid/serum ratios of IgA, IgG, and IgM were elevated in patients with malignant pleural effusions compared with patients with nonmalignant pleural effusion...

journal_title：Cancer

authors： Desai SD,Sackett DL

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Chemoradiation with 5-fluorouracil and mitomycin remains the standard of care for squamous cell carcinoma (SCC) of the anal canal. A prolonged treatment time is associated with inferior disease-specific outcomes. Radiation Therapy Oncology Group trial 0529 demonstrated decreased toxicity and fewer treatment ...

journal_title：Cancer

authors： Elson JK,Kachnic LA,Kharofa JR

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:The pretherapy prediction of occult lymph node involvement and the avoidance of otherwise futile and potentially morbid definitive local therapy is paramount in men with newly diagnosed prostate carcinoma. To identify patients with prostate carcinoma who likely have lymph node involvement and would benefit f...

journal_title：Cancer

authors： Polascik TJ,Manyak MJ,Haseman MK,Gurganus RT,Rogers B,Maguire RT,Partin AW

更新日期：1999-04-01 00:00:00

abstract：:Utah cancer mortality for the years 1950-1969 and morbidity for the years 1966-1970 are reported. Utah had 18% fewer cases of cancer than expected based on the Third National Cancer Survey, and 24% fewer cancer deaths than expected based on national mortality data. Cancer sites associated with cigarette smoking and al...

journal_title：Cancer

authors： Lyon JL,Gardner JW,Klauber MR,Smart CR

更新日期：1977-06-01 00:00:00

abstract：:Epidemiologic and laboratory data suggest that cervical cancer typically arises from a series of causal steps. Each step can be studied separately in the hope of better etiologic understanding and improved cancer prevention. The earliest identified etiologic step is infection of young women with specific types of vene...

journal_title：Cancer

authors： Schiffman MH,Brinton LA

更新日期：1995-11-15 00:00:00

abstract：:Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation...

journal_title：Cancer

authors： Friedlaender A,Drilon A,Banna GL,Peters S,Addeo A

更新日期：2020-11-15 00:00:00

abstract：BACKGROUND:Malignant cells exhibit increased glycolytic metabolism, and in many cases increased glucose transporter gene expression. The authors hypothesized that GLUT1 glucose transporter expression is increased in colorectal carcinoma, and that the degree of expression might have prognostic significance. METHODS:GLU...

journal_title：Cancer

authors： Haber RS,Rathan A,Weiser KR,Pritsker A,Itzkowitz SH,Bodian C,Slater G,Weiss A,Burstein DE

更新日期：1998-07-01 00:00:00

abstract：:The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...

journal_title：Cancer

authors： Stock RJ,Fu YS,Carter JR

更新日期：1979-09-01 00:00:00

abstract：:To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...

journal_title：Cancer

authors： Strauss A,Dritschilo A,Nathanson L,Piro AJ

更新日期：1981-03-15 00:00:00

abstract：BACKGROUND:Despite recent improvements in the treatment of acute lymphoblastic leukemia (ALL), adult patients still have an overall poor outcome. The future of ALL management relies on the introduction of novel targeted therapies. The authors sought to assess if protein kinases (PKs), frequently deregulated in cancer, ...

journal_title：Cancer

authors： Messina M,Chiaretti S,Tavolaro S,Peragine N,Vitale A,Elia L,Sica S,Levis A,Guarini A,Foà R

更新日期：2010-07-15 00:00:00

abstract：:Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fract...

journal_title：Cancer

authors： Lee YM,Jackson SM

更新日期：1985-01-15 00:00:00

abstract：:In order to validate xenografted small cell lung carcinomas (SCLC) for biological studies, the authors established 12 lung neuroendocrine (NE) tumors (eight typical SCLC and four atypical NE tumors [ANE]) by heterotransplantation onto nude mice. Their characterization was performed using serial ultrastructural, enzyma...

journal_title：Cancer

authors： Brambilla E,Jacrot M,Batandier C,Brichon PY,Morel F,Nagy-Mignotte H,Paramelle B,Brambilla C

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:The antiviral, proapoptotic, antiproliferative gene 2'-5' oligoadenylate synthetase (2-5OAS1) converts adenosine triphosphate into a series of 2'-5' oligoadenylates (2-5A). In turn, 2-5A activates latent ribonuclease (RNaseL), a candidate hereditary prostate cancer gene. OAS1 polymorphism (reference single n...

journal_title：Cancer

authors： Mandal S,Abebe F,Chaudhary J

更新日期：2011-12-15 00:00:00