2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.

abstract：BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

journal_title：Cancer

authors： Deligdisch L,Miranda C,Barba J,Gil J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Late menarche, early menopause, high parity, and early first birth decrease the risk of development of breast cancer. The influence of these factors on the survival of breast cancer patients has not been explained. METHODS:A group of 1885 patients with operable breast cancer was studied retrospectively. A u...

journal_title：Cancer

authors： Korzeniowski S,Dyba T

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...

journal_title：Cancer

authors： Pradier R,González A,Matos E,Loria D,Adan R,Saco P,Califano L

更新日期：1993-04-15 00:00:00

abstract：BACKGROUND:In animal models carbogen (normobaric 95% oxygen, 5% carbon dioxide) provides significant enhancement of local tumor control with fractionated radiotherapy. This approach to radiosensitization has been evaluated in the treatment of patients with bladder carcinoma using radical radiotherapy. METHODS:Sixty-on...

journal_title：Cancer

authors： Hoskin PJ,Saunders MI,Dische S

更新日期：1999-10-01 00:00:00

abstract：:Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...

journal_title：Cancer

authors： Liu J,Hudkins PG,Swee RG,Unni KK

更新日期：1987-04-01 00:00:00

abstract：:Blood was obtained on 36 occasions from 12 healthy adult volunteers and the polymorphonuclear leukocytes (PMNL) were separated. PMNL hexose monophosphate shunt activity of whole blood and ability of separated cells to phagocytize and kill E. coli were evaluated when the PMNL were incubated with normal pooled sera and ...

journal_title：Cancer

authors： Pickering LK,Ericsson CD,Kohl S

更新日期：1978-10-01 00:00:00

abstract：:Higher serum iron and ferritin levels noted in hepatitis B antigen (HBAg) carriers than in noncarriers suggests that virus might actively replicate in hepatocytes, stimulate ferritin synthesis, and result in increased liver iron stores. A comparative semiquantitative study of immunohistochemical ferritin (0-12) and he...

journal_title：Cancer

authors： Cohen C,Berson SD,Shulman G,Budgeon LR

更新日期：1985-11-01 00:00:00

abstract：:A prospective study of four cycles of etoposide with ifosfamide and cisplatin (VIP) chemotherapy was conducted in 42 germ cell tumor (GCT) patients who were refractory to cisplatin with etoposide/vinblastine-based therapy. Forty patients were evaluable for response. Ten patients (25%) had a complete response: seven to...

journal_title：Cancer

authors： Motzer RJ,Cooper K,Geller NL,Bajorin DF,Dmitrovsky E,Herr H,Morse M,Fair W,Sogani P,Russo P

更新日期：1990-12-15 00:00:00

abstract：:Eighty-nine primary lung carcinomas and 23 metastatic lung tumors were immunohistochemically studied for the expression of pulmonary surfactant apoproteins, by using monoclonal (PE-10) and polyclonal antibodies. Surfactant apoprotein was demonstrated in the cytoplasm and/or nuclear inclusion bodies of only primary lun...

journal_title：Cancer

authors： Mizutani Y,Nakajima T,Morinaga S,Gotoh M,Shimosato Y,Akino T,Suzuki A

更新日期：1988-02-01 00:00:00

abstract：:Two hundred-eighty patients were randomized to receive either BCNU, hydroxyurea and imidazole carboxamide (BHD), BHD plus levamisole, or high-dose DTIC plus actinomycin D. There was no difference in response rate in the three groups (24%, 25% and 22%). Females responded better than males and, as expected, those with a...

journal_title：Cancer

authors： Costanzi JJ,Fletcher WS,Balcerzak SP,Taylor S,Eyre HJ,O'Bryan RM,Al-Sarraf M,Frank J

更新日期：1984-02-15 00:00:00

abstract：:In 186 women with breast cancer, there was a progressive increase in the proportion of axillary nodal involvement as the number of pregnancies increased from zero to two or more (P = 0.026). Logistic regression analysis demonstrated that this effect was independent of the known relationship of age and tumor size to no...

journal_title：Cancer

authors： Lehrer S,Levine E,Savoretti P,Cropley J,Botstein C,Song HK,Mandell L,Shank B

更新日期：1992-02-15 00:00:00

abstract：:Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...

journal_title：Cancer

authors： Park CL,Pustejovsky JE,Trevino K,Sherman AC,Esposito C,Berendsen M,Salsman JM

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Patients with superficial (mucosal or submucosal) esophageal carcinoma (SEC) have significantly better survival rates than patients with advanced carcinoma. Some patients with advanced esophageal carcinoma have been reported to test positive for serum p53 antibodies (Abs). Because very few patients with supe...

journal_title：Cancer

authors： Shimada H,Takeda A,Arima M,Okazumi S,Matsubara H,Nabeya Y,Funami Y,Hayashi H,Gunji Y,Suzuki T,Kobayashi S,Ochiai T

更新日期：2000-10-15 00:00:00

abstract：:In 25 patients under treatment or during follow-up for acute lymphoblastic leukemia magnetic resonance imaging (MRI) of both knees was compared to history and physical examination to detect osteonecrosis. Results of MRI were classified as: O, normal bone marrow (BM); 1, diffuse decrease in signal intensity; 2, circums...

journal_title：Cancer

authors： Pieters R,van Brenk AI,Veerman AJ,van Amerongen AH,van Zanten TE,Golding RP

更新日期：1987-12-15 00:00:00

abstract：BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...

journal_title：Cancer

authors： Locati LD,Licitra L,Agate L,Ou SH,Boucher A,Jarzab B,Qin S,Kane MA,Wirth LJ,Chen C,Kim S,Ingrosso A,Pithavala YK,Bycott P,Cohen EE

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Tobacco smoking, alcohol abuse, and high-risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing ...

journal_title：Cancer

authors： Perrone F,Mariani L,Pastore E,Orsenigo M,Suardi S,Marcomini B,DaRiva L,Licitra L,Carbone A,Pierotti MA,Pilotti S

更新日期：2007-06-15 00:00:00

abstract：:Canada is a westernized, market-economy nation with a publicly funded health care and cancer control system and has health indices reflective of a high-resource economy. Provision of health services is in accord with the Canada Health Act and is implemented through federal, provincial, and territorial relations wherei...

journal_title：Cancer

authors： Sutcliffe SB

更新日期：2011-05-15 00:00:00

abstract：:Therapy for acute lymphocytic leukemia (ALL) has been less successful in adults than in children. Many centers treat all adult leukemia with the same regimen. We have used vincristine and prednisone for initial therapy in 14 adults with ALL since 1971 and have followed a treatment regimen developed for childhood ALL f...

journal_title：Cancer

authors： Scavino HF,George JN,Sears DA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...

journal_title：Cancer

authors： Baldazzi V,Tassi R,Lapini A,Lunghi A,Garofoli E,Caruso S,Carini M,Mazzanti R

更新日期：2012-06-15 00:00:00

abstract：:Twenty-five patients with advanced measurable adenocarcinoma of the lung were treated with combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin-C (FAM). Objective response (1CR, 8PR) was obtained in 36% of patients. The median duration of response was 7.0 months and the median survival for ...

journal_title：Cancer

authors： Butler TP,MacDonald JS,Smith FP,Smith LF,Woolley PV,Schein PS

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...

journal_title：Cancer

authors： Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

更新日期：2007-04-01 00:00:00

abstract：:One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses ...

journal_title：Cancer

authors： Viladiu P,Alonso MC,Avella A,Beltrán M,Borrás J,Ojeda B,Bosch FX

更新日期：1985-12-15 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) has been shown to be the principal cause of humoral hypercalcemia associated with renal cell carcinoma (RCC). Recent studies have demonstrated that the amino-terminal region of PTHrP has growth factor-like activities, suggesting it may play a role in the developmen...

journal_title：Cancer

authors： Iwamura M,Wu W,Muramoto M,Ohori M,Egawa S,Uchida T,Baba S

更新日期：1999-09-15 00:00:00

abstract：:The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for the...

journal_title：Cancer

authors： Ludmir EB,Palta M,Willett CG,Czito BG

更新日期：2017-05-01 00:00:00

abstract：:The epidemiologic pattern for Hodgkin's disease in blacks from two different communities in the United States was characterized by higher childhood rates and significantly lower rates in the young adult and older age groups than for whites. In addition, a significantly greater number of black patients belonged to low ...

journal_title：Cancer

authors： Vianna NJ,Thind IS,Louria DB,Polan A,Kirmss V,Davies JN

更新日期：1977-12-01 00:00:00

abstract：:The possible influence of histologic grade, necrosis and size of invasive breast cancers on the five year survival rate of women treated in NSABP clinical trials with regimens of L-PAM (P) and L-PAM + 5-FU (PF) and for four years in those receiving L-PAM + 5-FU + methotrexate (PMF) was investigated. Generally, all reg...

journal_title：Cancer

authors： Fisher ER,Redmond C,Fisher B

更新日期：1983-01-15 00:00:00

abstract：:Prostatic intra-epithelial neoplasia (PIN, or intraductal dysplasia) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. The highest grade of PIN, Grade 3, is thought to represent carcinoma in situ. To quantitate the degree of disrupt...

journal_title：Cancer

authors： Bostwick DG,Brawer MK

更新日期：1987-02-15 00:00:00

abstract：:Routine morphologic and cytochemical study of the leukemic cells of a 13-month-old child did not permit definitive determination of either a lymphoid or a myeloid cell origin. However, ultrastructural cytochemical analysis revealed platelet peroxidase (PPO) reactivity. The malignant cells expressed PPO in both unfixed...

journal_title：Cancer

authors： Sariban E,Oliver C,Corash L,Cossman J,Whang-Peng J,Jaffe ES,Gralnick HR,Poplack DG

更新日期：1984-10-01 00:00:00

abstract：:A low-dose maintenance schedule of Adriamycin was evaluated in six children whose metastatic solid tumors regressed following toxic induction therapy with Adriamycin. Three of these children are now disease-free more than one year following discontinuation of therapy. Adriamycin can be given on a low-dose maintenance ...

journal_title：Cancer

authors： Hvizdala EV,Komp DM,Arnold JB

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...

journal_title：Cancer

authors： Reckamp KL,Koczywas M,Cristea MC,Dowell JE,Wang HJ,Gardner BK,Milne GL,Figlin RA,Fishbein MC,Elashoff RM,Dubinett SM

更新日期：2015-09-15 00:00:00