Abstract:
:Therapy for acute lymphocytic leukemia (ALL) has been less successful in adults than in children. Many centers treat all adult leukemia with the same regimen. We have used vincristine and prednisone for initial therapy in 14 adults with ALL since 1971 and have followed a treatment regimen developed for childhood ALL for subsequent therapy as well. Complete remissions were attained in 13, and complications and duration of hospitalization were minimized with this nonmyelotoxic regimen. Central nervous system "prophylactic" therapy was also well tolerated in these adult patients. However, remission duration and survival in our series were similar to those reported by others. That complete remission can be attained in a high percentage of adult patients with ALL through use of relatively nontoxic treatment demonstrates the importance of selecting out this group of patients from all adults with acute leukemia.
journal_name
Cancerjournal_title
Cancerauthors
Scavino HF,George JN,Sears DAdoi
10.1002/1097-0142(197608)38:2<672::aid-cncr2820380subject
Has Abstractpub_date
1976-08-01 00:00:00pages
672-7issue
2eissn
0008-543Xissn
1097-0142journal_volume
38pub_type
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