Abstract:
BACKGROUND:During a population-based local cancer registry, a peculiar type of T-cell lymphoma restricted to the gastrointestinal tract was found in patients living in southwestern Japan. METHODS:Five cases of gastrointestinal (GI) tract T-cell lymphoma were analyzed with immunohistologic examination, ultrastructural analysis, in situ hybridization (ISH), and polymerase chain reaction (PCR). RESULTS:All cases satisfied the criteria of primary GI tract lymphoma at presentation or operation. Four showed a close relationship to human T-cell lymphotropic virus type I (HTLV-I). Those four had positive results for anti-HTLV-I antibody and positive surface markers for CD4, positive hybridization signals by ISH, and HTLV-I gene products by PCR, but they had no lymphoma cells in peripheral blood or bone marrow. The fifth case showed negative signals by ISH and PCR. CONCLUSIONS:These findings suggest that some of the putative adult T-cell leukemia/lymphoma (ATLL) types can be further classified as GI-tract-type lymphoma. The prognosis for the GI tract type is as poor as it is for conventional ATLL.
journal_name
Cancerjournal_title
Cancerauthors
Tokunaga O,Watanabe T,Shimamoto Y,Tokudome Sdoi
10.1002/1097-0142(19930201)71:3<708::aid-cncr28207subject
Has Abstractpub_date
1993-02-01 00:00:00pages
708-16issue
3eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
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