Combined modality therapy in Stage III and Stage IIIE diffuse large cell lymphomas.

Abstract:

:Combined modality therapy consisting of CHOP-Bleo (cyclophosphamide, Adriamycin [doxorubicin], vincristine (Oncovin), prednisone, and bleomycin) and limited-field radiotherapy was given to 47 patients with Stage III and IIIE diffuse large cell lymphomas. Overall 5-year survival and disease-free survival figures are 64% and 53%, respectively. Twenty-nine patients achieved and maintained a complete remission during treatment; 92% of these patients are alive at 5 years, and 87% are disease-free. Prognostic factors were assessed for the entire group. Age, "B" symptoms, extranodal involvement, and extensive abdominal involvement had little effect on survival. However, the presence of mediastinal involvement and extensive abdominal involvement was associated with a poor response rate and survival.

journal_name

Cancer

journal_title

Cancer

authors

Velasquez W,Fuller LM,Oh KK,Hagemeister FB,Sullivan JA,Manning JT,Shullenberger CC

doi

10.1002/1097-0142(19840401)53:7<1478::aid-cncr2820

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

1478-83

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

53

pub_type

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