Abstract:
BACKGROUND:African-American (AA) and white patients with early-stage disease who were treated with breast conservation therapy (BCT) were examined to detect differences in clinicopathologic features and outcomes as a function of race. METHODS:Clinical data from the charts of 2164 white and 207 AA patients treated with BCT, and p53 expression status on 444 patients (from an existing tissue database), were analyzed to detect differences between the 2 cohorts. RESULTS:The median follow-up was 7 years. There were no differences in the method of tumor detection, lymph nodes excised, surgical margin status, or chemotherapy/radiotherapy delivered, reflecting similar screening and treatment policies for AA women in the study community. Despite this, AA patient presented at a younger age, with higher T and N classifications, and more estrogen and progesterone negative and "triple negative" tumors (all P values < .016). Tumors in AA patients were p53 positive more often than tumors in white patients (P= .0003). At 10 years, AA patients had a higher rate of distant metastasis (20% vs 17%; P= .042), lymph node recurrence (6% vs 2%; P= .004), and breast recurrence (17% vs 13%; P= .036). There was no difference in overall survival between the 2 groups. On multivariate analysis, only lymph node recurrence (risk ratio of 3.140; 95% confidence interval, 1.396-7.063 [P= .0057]) remained significantly higher among AA women. CONCLUSIONS:In this cohort of uniformly treated patients, the authors found the expected clinicopathologic differences, but race was not found to be an independent predictor of local recurrence for AA patients when other confounding variables were taken into account in the multivariate model. These findings suggest that BCT is a reasonable option for appropriately selected AA patients. To the authors' knowledge, this is the largest study addressing outcomes after BCT for AA women published to date.
journal_name
Cancerjournal_title
Cancerauthors
Moran MS,Yang Q,Harris LN,Jones B,Tuck DP,Haffty BGdoi
10.1002/cncr.23881subject
Has Abstractpub_date
2008-11-01 00:00:00pages
2565-74issue
9eissn
0008-543Xissn
1097-0142journal_volume
113pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22807
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, relatively little is known regarding the interaction of risk factors for hepatocellular carcinoma (HCC) with age, sex, and liver disorder status. METHODS:The authors followed 504,646 Korean patients aged 40 to 80 years who underwent routine health checkups between 2002 and 2003 un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31406
更新日期:2018-07-01 00:00:00
abstract::Based on laboratory studies showing enhanced cytotoxicity of floxuridine (FUDR) when used with high doses of leucovorin (LV), a pilot study of FUDR and LV through an implantable pump was initiated for the treatment of hepatic metastases from colorectal cancer. The highest dose of LV that could be administered, taking ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900601)65:11<2446::aid-cncr282
更新日期:1990-06-01 00:00:00
abstract::In view of the rarity of small-bowel epithelial neoplasms as compared with the case for the large bowel, evidence for an adenoma-carcinoma sequence in the small bowel was studied based on a search for data in the medical literature for the years 1927 through 1986. Sufficiently defined data were found for comparison of...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900815)66:4<702::aid-cncr28206
更新日期:1990-08-15 00:00:00
abstract:BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a+ )/CD207+ histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31893
更新日期:2019-03-15 00:00:00
abstract::Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910215)67:4+<1121::aid-cncr282
更新日期:1991-02-15 00:00:00
abstract::The purpose of this study was to characterize the clinical features of laboratory-confirmed influenza in 20 children and young adults with cancer who were receiving immunosuppressive therapy. Viruses isolated from pharyngeal and nasopharyngeal cultures were identified as the A/Hong Kong/1/68 strain or one of its varia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197701)39:1<350::aid-cncr2820390
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Some studies have suggested that the use of calcium channel blockers may increase the risk of cancer. A possible association of the use of calcium channel blockers with cancer incidence and cancer mortality was addressed using data from the Nurses' Health Study. METHODS:In this study, a total of 18,635 fema...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Breast cancer is one of the most responsive of the common solid tumors when systemic therapy is indicated in the treatment of locally advanced or disseminated cancer. Many single agents have been useful in inducing remission in mammary carcinoma, but in recent years various drug combinations have been developed that a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4+<1079::aid-cncr282
更新日期:1980-08-15 00:00:00
abstract:BACKGROUND:The frequency of mutant p53 in bone marrow metastases of patients with carcinoma of the prostate (CaP) and in matched sets of metastatic and primary lesions from the same patients was investigated. The data were examined in relation to prior treatment with androgen ablation (AA) therapy and were compared wit...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-15 00:00:00
abstract::The authors report four patients whose initial symptom of tumor recurrence or progression was unilateral numbness of the chin. Two patients had Hodgkin lymphoma, one had malignant melanoma, and one had prostate cancer. Physical examination was notable only for unilateral anesthesia of the chin and lower lip. Diagnosti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920815)70:4<877::aid-cncr28207
更新日期:1992-08-15 00:00:00
abstract:BACKGROUND:Hepatectomy is the standard of care for patients with colorectal cancer who have isolated hepatic metastases; however, the long-term survival benefits of hepatectomy in this population have not been characterized well outside of case series. For the current study, a population-based database was used to comp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22448
更新日期:2007-02-15 00:00:00
abstract:BACKGROUND:Breast cancers that are negative for the estrogen receptor (ER), the progesterone receptor (PR), and the HER2 (human epidermal growth factor receptor 2) marker are more prevalent among African women, and the biologically aggressive nature of these triple-negative breast cancers (TNBCs) may be attributed to t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27737
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The current analysis of outcomes in a large series of adult patients with intracranial ependymal tumors contributes to the characterization of the primary prognostic factors and to the therapeutic management of this rare disease, for which limited information is available in the literature. METHODS:The auth...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20074
更新日期:2004-03-15 00:00:00
abstract::Twenty-one cases of clear cell adenocarcinoma of the cervix and vagina have been reviewed. Fifteen cases occurred in females under 25 years of age and four in women over 45 years. In seven cases, a positive history of maternal ingestion of diethylstilbestrol (DES) was obtained. One mother gave a history of medication ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<858::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22016
更新日期:2006-09-01 00:00:00
abstract::Twenty-five patients with advanced measurable adenocarcinoma of the lung were treated with combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin-C (FAM). Objective response (1CR, 8PR) was obtained in 36% of patients. The median duration of response was 7.0 months and the median survival for ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1183::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distrib...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21840
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:Nonperioperative strokes are rare yet potentially devastating events for children with central nervous system (CNS) tumors. The incidence of and risk factors for nonperioperative strokes in children with CNS tumors is unknown. METHODS:The authors performed a retrospective review of children from their insti...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::There are three principal disturbances in bone remodelling that occur in neoplasia affecting the skeleton. The first is an increase in bone turnover that in solid tumors may be confined to sites of metastases or be a generalized phenomenon, most likely related to the secretion of parathyroid hormone-related protein. I...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1538::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Spouses of cancer survivors are at an increased risk of poor mental health outcomes but are known to underuse supportive services. The objective of the current study was to determine how the health and health care use of cancer survivors were associated with depression and anxiety-related health care use in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33345
更新日期:2020-12-08 00:00:00
abstract:BACKGROUND:Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine-needle aspiration (FNA) specimens. Potential diagnostic problems may arise due to morphologic heterogeneity of myoepithelial cell-rich lesions and difficulty in predicting malignancy in FNA specimens. An accurate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20642
更新日期:2004-12-25 00:00:00
abstract:BACKGROUND:Cyclin-dependent kinases (CDK) and cyclins constitute the subunits of the maturation-promoting factor that controls the process of cell division. High levels of these proteins have been reported in human malignancies of the stomach, colon, breast, and lung, and have been implicated in aberrant cell division ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970815)80:4<753::aid-cnc
更新日期:1997-08-15 00:00:00
abstract::Three bleomycin-resistant (BLMr) human carcinoma cell lines (HeLa-BLMr, KB-BLMr, and Hepd-uvBLMr) were established in culture by progressively increasing the concentration of bleomycin (BLM). HeLa-BLMr and KB-BLMr were obtained after 5 and 2 months of incubation with BLM, whereas the establishment of Hepd-uvBLMr requi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880415)61:8<1501::aid-cncr2820
更新日期:1988-04-15 00:00:00
abstract:BACKGROUND:Sipuleucel-T is an investigational active cellular immunotherapy product designed to stimulate an immune response against prostate cancer. The safety and efficacy of sipuleucel-T was evaluated in 2 identically designed, randomized, double-blind, placebo-controlled trials (D9901 and D9902A) conducted in men w...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.24429
更新日期:2009-08-15 00:00:00
abstract:BACKGROUND:The outcome of surgical treatment for early gastric cancer (EGC) generally is considered to be satisfactory. Although a small percentage of patients experience disease recurrence, the absolute number of such instances is too small for assessment of risk factors. METHODS:The authors investigated the follow-u...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19931201)72:11<3174::aid-cncr282
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:There are few reports comparing the clinicopathologic features of sarcomas of the aorta (SA), sarcomas of the inferior vena cava (SIVC), and sarcomas of the pulmonary artery (SPA). METHODS:The authors retrospectively reviewed 11 SA, 16 SIVC, and 16 SPA, and compared clinical, pathologic, and immunohistochem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930301)71:5<1761::aid-cncr2820
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:MYCN gene amplification (MNA) is a hallmark of aggressive neuroblastoma. This study was performed to determine univariate and multivariate predictors of tumor MNA. METHODS:Data from the International Neuroblastoma Risk Group were analyzed for a subset of 7102 patients with known MYCN status. Chi-square test...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29848
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30916
更新日期:2017-12-01 00:00:00
abstract::In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820
更新日期:1987-04-15 00:00:00