Investigations on the significance of the adenoma-carcinoma sequence in the small bowel.

Abstract:

:In view of the rarity of small-bowel epithelial neoplasms as compared with the case for the large bowel, evidence for an adenoma-carcinoma sequence in the small bowel was studied based on a search for data in the medical literature for the years 1927 through 1986. Sufficiently defined data were found for comparison of 185 benign adenomas, 76 adenoma-with-carcinomas, and 1333 carcinomas in patients without familial polyposis disease and for 63, five, and 30, respectively, in patients with disease. For patients without polyposis, it was found that (1) 29.8% of all small-bowel adenomas (33.6% if those at Vater's ampulla are excluded) showed malignancy; (2) the mean and median ages were lower for benign adenoma than for adenoma-with-carcinoma and carcinoma, although the ratios by sex were the same; (3) there is a nearly identical spatial distribution of the three types of epithelial neoplasms within the small bowel; and (4) both the frequency of finding adenomatous residues existing in continuity with carcinoma and the life history of the adenoma-carcinoma sequence are similar in the small bowel as in the large. In comparing these results with those from patients with familial polyposis disease, it was particularly noted that (1) the only difference was that adenomas in familial polyposis occurred earlier and multiply, and (2) the spatial distributions of adenomas and carcinomas for both cases were closely similar. It is therefore postulated that the adenoma-carcinoma sequence is as significant in the small bowels as in the large. A hypothesis regarding the relationship of epithelial neoplasms in people with and without familial polyposis disease is suggested.

journal_name

Cancer

journal_title

Cancer

authors

Sellner F

doi

10.1002/1097-0142(19900815)66:4<702::aid-cncr28206

subject

Has Abstract

pub_date

1990-08-15 00:00:00

pages

702-15

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

66

pub_type

杂志文章,评审

相关文献

CANCER文献大全
  • Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma.

    abstract:BACKGROUND:The sensitivity of the intraoperative diagnosis of sentinel lymph node (SLN) micrometastases and the metastases of invasive lobular carcinoma (ILC) is low. The goal of the current study was to assess whether the use of intraoperative, rapid immunohistochistochemistry (IHC) enhances the intraoperative detecti...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.21133

    authors: Leikola JP,Toivonen TS,Krogerus LA,von Smitten KA,Leidenius MH

    更新日期:2005-07-01 00:00:00

  • International Federation of Gynecology and Obstetrics staging of endometrial cancer 1988.

    abstract::In 1988, the International Federation of Gynecology and Obstetrics (FIGO) Cancer Committee changed the staging of endometrial carcinoma from a clinical one to a surgicopathologic one. The emphasis in the new FIGO system was changed to the pathologic findings in the uterus, cervix, adnexa, and pelvic and/or periaortic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820710409

    authors: Mikuta JJ

    更新日期:1993-02-15 00:00:00

  • An aggressive approach to marginally resectable lung cancer.

    abstract::Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197805)41:5<2040::aid-cncr282041

    authors: Sherman DM,Neptune W,Weichselbaum R,Order SE,Piro AJ

    更新日期:1978-05-01 00:00:00

  • Paclitaxel-based second-line therapy for patients with advanced chemotherapy-resistant bladder carcinoma (M1): a clinical Phase II study.

    abstract:BACKGROUND:In a previous clinical trial, the authors disclosed that the expression of tumor cell motility factor gp78hAMFR correlates with tumor progression in patients with bladder carcinoma. This study was initiated to evaluate whether the combination of cytostatic drugs with an antimotility factor has an effect on c...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19970801)80:3<465::aid-cnc

    authors: Otto T,Bex A,Krege S,Walz PH,Rübben H

    更新日期:1997-08-01 00:00:00

  • Pathology of small hepatocellular carcinoma. A proposal for a new gross classification.

    abstract::Review of 61 surgically resected small hepatocellular carcinomas (HCC) less than or equal to 3 cm in diameter yielded a simple gross classification system of five types based on tumor shape, which is highly correlated with microscopic and clinical features, including prognosis. Type 1 (single nodular type) tumors (n =...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870815)60:4<810::aid-cncr28206

    authors: Kanai T,Hirohashi S,Upton MP,Noguchi M,Kishi K,Makuuchi M,Yamasaki S,Hasegawa H,Takayasu K,Moriyama N

    更新日期:1987-08-15 00:00:00

  • The prevalence of patients with colorectal carcinoma under care in the U.S.

    abstract:BACKGROUND:Prevalence usually is defined as the proportion of individuals alive who previously had a diagnosis of the disease, regardless of whether the individuals still are receiving treatment or are cured. The objective of this study was to estimate the proportion of elderly patients with colorectal carcinoma (CRC) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11631

    authors: Mariotto A,Warren JL,Knopf KB,Feuer EJ

    更新日期:2003-09-15 00:00:00

  • Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme.

    abstract:BACKGROUND:After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin. METHODS:In this study, the authors prospectively enrolled 25 patients with GBM who underwent gross total resection followed by adjuvan...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.23624

    authors: Mangiola A,de Bonis P,Maira G,Balducci M,Sica G,Lama G,Lauriola L,Anile C

    更新日期:2008-08-15 00:00:00

  • Hepatic dearterialization for nonrespectable primary and secondary tumors of the liver.

    abstract::Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197612)38:6<2593::aid-cncr282038

    authors: Nagasue N,Inokuchi K,Kobayashi M,Ogawa Y,Iwaki A

    更新日期:1976-12-01 00:00:00

  • Health care cost and utilization project analysis of comorbid illness and complications for patients undergoing hysterectomy for endometrial carcinoma.

    abstract:OBJECTIVE:The objective was to study the association of race, comorbid illness, and lymph node dissection (LND) with complications in patients undergoing hysterectomy for endometrial carcinoma. METHODS:The Health Care Cost Utilization Project analysis studied women undergoing hysterectomy for endometrial carcinoma in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010815)92:4<950::aid-cncr1405>

    authors: Brooks SE,Ahn J,Mullins CD,Baquet CR,D'Andrea A

    更新日期:2001-08-15 00:00:00

  • Analgesics and cancer of the renal pelvis in New South Wales.

    abstract::A lifetime history of analgesics and tobacco consumption was obtained by a questionnaire completed at interview from 67 patients with carcinoma of the renal pelvis (40 women, 27 men) and 180 control subjects drawn from two sources, friends of patients and persons attending a health screening clinic. Regular consumptio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820615)49:12<2617::aid-cncr282

    authors: McCredie M,Ford JM,Taylor JS,Stewart JH

    更新日期:1982-06-15 00:00:00

  • Underestimation of malignancy of breast core-needle biopsy: concepts and precise overall and category-specific estimates.

    abstract:BACKGROUND:A review of the literature indicated variable underestimation rates for breast core-needle biopsy (CNB) based on generally small series. In this article, the authors present precise estimates for overall underestimation and for categories of histologic underestimates (including categories that reflect contem...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.22435

    authors: Houssami N,Ciatto S,Ellis I,Ambrogetti D

    更新日期:2007-02-01 00:00:00

  • Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors.

    abstract:BACKGROUND:A new, internationally accepted histologic classification of renal cell carcinoma (RCC) and a new edition of the TNM staging system were introduced in 1997. In the latter, there was a dramatic change in the pT classification of organ-confined renal cancer in which the break point between category pT1 and pT2...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Moch H,Gasser T,Amin MB,Torhorst J,Sauter G,Mihatsch MJ

    更新日期:2000-08-01 00:00:00

  • Interaction of molecular alterations with immune response in melanoma.

    abstract::Major advances have been made in melanoma treatment with the use of molecularly targeted therapies and immunotherapies, and numerous regimens are now approved by the US Food and Drug Administration for patients with stage IV disease. However, therapeutic resistance remains an issue to both classes of agents, and relia...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.30681

    authors: Szczepaniak Sloane RA,Gopalakrishnan V,Reddy SM,Zhang X,Reuben A,Wargo JA

    更新日期:2017-06-01 00:00:00

  • Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature.

    abstract:BACKGROUND:The outcome of surgical treatment for early gastric cancer (EGC) generally is considered to be satisfactory. Although a small percentage of patients experience disease recurrence, the absolute number of such instances is too small for assessment of risk factors. METHODS:The authors investigated the follow-u...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19931201)72:11<3174::aid-cncr282

    authors: Sano T,Sasako M,Kinoshita T,Maruyama K

    更新日期:1993-12-01 00:00:00

  • Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls.

    abstract:BACKGROUND:This study examined the influence of prior treatment on the course of cognitive functioning in breast cancer survivors. Changes in cognitive functioning over time were compared in breast cancer survivors treated with chemotherapy plus radiotherapy, breast cancer survivors treated with radiotherapy only, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26432

    authors: Phillips KM,Jim HS,Small BJ,Laronga C,Andrykowski MA,Jacobsen PB

    更新日期:2012-04-01 00:00:00

  • Flow cytometric DNA-ploidy analysis of synchronously occurring multiple malignant tumors of the female genital tract.

    abstract::In this study the authors applied flow cytometric DNA-ploidy analysis to multiple female genital tract malignant tumors in 43 patients, most of whom (n = 37) had bilateral ovarian cancer. An algorithm was developed for calculation of the likelihood ratio of the probabilities that measured DNA index differences between...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Smit VT,Fleuren GJ,van Houwelingen JC,Zegveld ST,Kuipers-Dijkshoorn NJ,Cornelisse CJ

    更新日期:1990-10-15 00:00:00

  • Marrow neutrophil reserve after adjuvant chemotherapy for carcinoma of the breast.

    abstract::The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820615)49:12<2455::aid-cncr282

    authors: Corder MP,Jochimsen PR

    更新日期:1982-06-15 00:00:00

  • 67Ga accumulation in pulmonary lesions associated with bleomycin toxicity.

    abstract::The radionuclide, gallium-67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of 67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigrap...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820360906

    authors: Richman SD,Levenson SM,Bunn PA,Flinn GS,Johnston GS,DeVita VT

    更新日期:1975-12-01 00:00:00

  • Adenocarcinoma of the stomach: review of 1,497 cases.

    abstract::The records of 1,497 patients with histologically proven adenocarcinoma of the stomach were reviewed from Charity Hospital over the 25-year period, 1948 to 1973. The operability rate was 82% and the resectability rate was 48%. In this series gastric carcinoma predominated in males and Negroes. Necropsy studies indicat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197803)41:3<941::aid-cncr2820410

    authors: Dupont JB Jr,Lee JR,Burton GR,Cohn I Jr

    更新日期:1978-03-01 00:00:00

  • Influence of patients' preferences and treatment site on cancer patients' end-of-life care.

    abstract:BACKGROUND:Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending therapy was associated with their EOL care. METHODS:Coping with Cancer is a multisite, prospect...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.25217

    authors: Wright AA,Mack JW,Kritek PA,Balboni TA,Massaro AF,Matulonis UA,Block SD,Prigerson HG

    更新日期:2010-10-01 00:00:00

  • Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries.

    abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20014

    authors: Cooper GS,Koroukian SM

    更新日期:2004-01-15 00:00:00

  • Plasma sex hormone binding globulin in patients with prostatic carcinoma.

    abstract::The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900715)66:2<354::aid-cncr28206

    authors: Grasso M,Buonaguidi A,Mondina R,Borsellino G,Lania C,Banfi G,Rigatti P

    更新日期:1990-07-15 00:00:00

  • Identification of high-grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples.

    abstract:BACKGROUND:Current cervical cancer screening approaches are based on cytology supplemented by human papillomavirus (HPV) testing in some settings. Whereas cytology is laborious and depends on the cytologists' experience, HPV testing has limited specificity when it is used to detect high-grade lesions. A dichotomous tes...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22247

    authors: Wentzensen N,Hampl M,Herkert M,Reichert A,Trunk MJ,Poremba C,Ridder R,von Knebel Doeberitz M

    更新日期:2006-11-01 00:00:00

  • Multifocal osteosarcoma: a case report with review of the literature.

    abstract::Multifocal osteosarcoma with unique patho-biological features in a 23-year old white male is reported. The natural history and classification of multiple osteosarcomas are reviewed. A proposal is presented for evaluation of the multicentric origin in future cases. ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197911)44:5<1897::aid-cncr282044

    authors: Mahoney JP,Spanier SS,Morris JL

    更新日期:1979-11-01 00:00:00

  • Risk factors for infections with multidrug-resistant Stenotrophomonas maltophilia in patients with cancer.

    abstract:BACKGROUND:Stenotrophomonas maltophilia is responsible for an increasing number of infections, especially in hospitalized patients. Therapy options are limited and trimethoprim/sulfamethoxazole (TMP/SMX) is often the main treatment option for this infection. In the current study, the risk factors were determined for th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22705

    authors: Ansari SR,Hanna H,Hachem R,Jiang Y,Rolston K,Raad I

    更新日期:2007-06-15 00:00:00

  • Estrogen and progesterone receptors in ovarian cancer.

    abstract::To determine whether steroid hormone receptor expression is clinically relevant in ovarian cancer, cytoplasmic and nuclear estrogen (ER) and progesterone (PR) receptor levels have been measured and their concentration calculated by Scatchard analysis. Of 89 samples from patients with non-pretreated epithelial ovarian ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<486::aid-cncr28206

    authors: Harding M,Cowan S,Hole D,Cassidy L,Kitchener H,Davis J,Leake R

    更新日期:1990-02-01 00:00:00

  • Efficacy of follow-up bone scans in carcinoma of the prostate.

    abstract::Three hundred fifteen radioisotopic bone scans ranging from initial scan only to nine scans per patient, performed on 114 patients with adenocarcinoma of the prostate between 1979 and 1984, were reviewed. Seventeen patients had positive scans, ten on initial scan and seven at follow-up. Nine patients had bone pain at ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880615)61:12<2453::aid-cncr282

    authors: Corrie D,Timmons JH,Bauman JM,Thompson IM

    更新日期:1988-06-15 00:00:00

  • Hormone replacement therapy and lung cancer risk in Chinese.

    abstract:BACKGROUND:The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies. There is a high female to male ratio in Chinese lung cancer patients, and female patients have different clinicopathological characteristics compared with Western patient population...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22987

    authors: Chen KY,Hsiao CF,Chang GC,Tsai YH,Su WC,Perng RP,Huang MS,Hsiung CA,Chen CJ,Yang PC,GEFLAC Study Group.

    更新日期:2007-10-15 00:00:00

  • Pulmonary rhabdomyosarcoma with isolated small bowel metastasis. A report of a case with immunohistochemical and ultrastructural studies.

    abstract::A unique case of pulmonary rhabdomyosarcoma with an isolated, symptomatic small bowel metastasis is presented. The tumor affected the middle lobe, and was treated with a right pneumonectomy. Eleven months after the operation, an isolated small bowel metastasis, which produced intestinal obstruction, was resected. The ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840501)53:9<1948::aid-cncr2820

    authors: Avagnina A,Elsner B,De Marco L,Bracco AN,Nazar J,Pavlovsky H

    更新日期:1984-05-01 00:00:00

  • Immune hemolytic anemia associated with streptococcal preparation OK-432.

    abstract::In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820

    authors: Nomura S,Kanoh T

    更新日期:1987-04-15 00:00:00