Mental neuropathy (numb chin syndrome). A harbinger of tumor progression or relapse.


:The authors report four patients whose initial symptom of tumor recurrence or progression was unilateral numbness of the chin. Two patients had Hodgkin lymphoma, one had malignant melanoma, and one had prostate cancer. Physical examination was notable only for unilateral anesthesia of the chin and lower lip. Diagnostic evaluation, including computed tomography (CT) scan and magnetic resonance imaging (MRI) of the brain, plain radiographs of the mandible, and cerebrospinal fluid analysis for protein, glucose, and cytology were normal. Bone scans revealed osseous lesions in the axial skeleton of all patients, whereas only two patients had abnormal uptake in the mandible. The authors conclude that in the setting of a negative evaluation for central nervous system (CNS) or local mandibular disease, mental neuropathy is associated with recurrent or progressive skeletal disease. In addition, to document relapsed or progressive cancer, the skeletal system may have to be examined at sites distant from the mandible.






Burt RK,Sharfman WH,Karp BI,Wilson WH




Has Abstract


1992-08-15 00:00:00














  • Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients.

    abstract:BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date. METHODS:The authors analyzed all patients who had localized and/...


    pub_type: 杂志文章


    authors: Zhang H,Travis LB,Chen R,Hyrien O,Milano MT,Newlands SD,Chen Y

    更新日期:2012-03-01 00:00:00

  • Government support of cancer research and cancer care health benefits.

    abstract::As the federal government struggles to meet ever-growing budgetary constraints, the need for research into the causes of and potential therapies for treating cancer demands the urgent attention of Congressional leaders. This will require innovative, cost-effective approaches to address the unique needs of cancer resea...


    pub_type: 杂志文章


    authors: Mack C

    更新日期:1993-11-01 00:00:00

  • Development of prognostic factors and survival in cutaneous melanoma over 25 years: An analysis of the Central Malignant Melanoma Registry of the German Dermatological Society.

    abstract:BACKGROUND:Recent studies revealed that incidence rates of cutaneous melanoma (CM) were leveling off predominantly among younger people and patterns suggested birth-cohort effects. The current study analyzed the development of prognostic factors and survival in incident CM over 25 years. METHODS:All 45,483 patients wi...


    pub_type: 杂志文章


    authors: Buettner PG,Leiter U,Eigentler TK,Garbe C

    更新日期:2005-02-01 00:00:00

  • Dynamic alterations of the extracellular environment of ovarian surface epithelial cells in premalignant transformation, tumorigenicity, and metastasis.

    abstract:BACKGROUND:Ovarian surface epithelial cells are positionally organized as a single cell layer by a sheet of basement membrane. It is believed that the contact of the ovarian surface epithelial cells with the basement membrane regulates cell growth and ensures the organization of the epithelium. Disabled-2 (Dab2), a sig...


    pub_type: 杂志文章


    authors: Capo-Chichi CD,Smith ER,Yang DH,Roland IH,Vanderveer L,Cohen C,Hamilton TC,Godwin AK,Xu XX

    更新日期:2002-10-15 00:00:00

  • Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.

    abstract::The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated. There were 17 patients with acute myelogenous leukemia (AML), six with acute lymphocytic leukemia (ALL), and one with biphenotypic leukemia. In this series of 24 patients whose disease had relapsed and who ha...


    pub_type: 杂志文章


    authors: Arlin ZA,Feldman EJ,Mittelman A,Ahmed T,Puccio C,Chun HG,Cook P,Baskind P,Marboe C,Mehta R

    更新日期:1991-09-15 00:00:00

  • Bone mineral density in young adult survivors of acute lymphoblastic leukemia.

    abstract:BACKGROUND:The purpose of the current study was to determine the prevalence of low bone mineral density (BMD) (ie, osteopenia) and identify factors associated with low BMD in young adult survivors of childhood acute lymphoblastic leukemia (ALL). METHODS:Dual energy x-ray absorptiometry was used to evaluate BMD in 74 r...


    pub_type: 杂志文章


    authors: Thomas IH,Donohue JE,Ness KK,Dengel DR,Baker KS,Gurney JG

    更新日期:2008-12-01 00:00:00

  • Which strategies reduce breast cancer mortality most? Collaborative modeling of optimal screening, treatment, and obesity prevention.

    abstract:BACKGROUND:US breast cancer mortality is declining, but thousands of women still die each year. METHODS:Two established simulation models examine 6 strategies that include increased screening and/or treatment or elimination of obesity versus continuation of current patterns. The models use common national data on inci...


    pub_type: 杂志文章


    authors: Mandelblatt J,van Ravesteyn N,Schechter C,Chang Y,Huang AT,Near AM,de Koning H,Jemal A

    更新日期:2013-07-15 00:00:00

  • Clear cell carcinoma of the uterine endocervix with an in situ component.

    abstract::In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occ...


    pub_type: 杂志文章


    authors: Hasumi K,Ehrmann RL

    更新日期:1978-11-01 00:00:00

  • Reproducibility of cytologic atypia in repeat nipple duct lavage.

    abstract:BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients un...


    pub_type: 杂志文章


    authors: Johnson-Maddux A,Ashfaq R,Cler L,Naftalis E,Leitch AM,Hoover S,Euhus DM

    更新日期:2005-03-15 00:00:00

  • Applicability of randomized trials in radiation oncology to standard clinical practice.

    abstract:BACKGROUND:Randomized controlled trials (RCTs) are commonly used to inform clinical practice; however, it is unclear how generalizable RCT data are to patients in routine clinical practice. The authors of this report assessed the availability and applicability of randomized evidence guiding medical decisions in a cohor...


    pub_type: 杂志文章


    authors: Apisarnthanarax S,Swisher-McClure S,Chiu WK,Kimple RJ,Harris SL,Morris DE,Tepper JE

    更新日期:2013-08-15 00:00:00

  • Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma.

    abstract:BACKGROUND:Even when they are analogous in microscopic and macroscopic appearance, tumors vary in their response rates to radiotherapy. Cell culture and xenograft experiments with colorectal cell lines have demonstrated that wild-type p53 increases radiosensitivity. Hence, the authors investigated, in a well-defined po...


    pub_type: 杂志文章


    authors: Nehls O,Klump B,Holzmann K,Lammering G,Borchard F,Gruenagel HH,Gaco V,Gregor M,Porschen R

    更新日期:1999-06-15 00:00:00

  • Absence of premalignant histologic, molecular, or cell biologic alterations in prophylactic oophorectomy specimens from BRCA1 heterozygotes.

    abstract:BACKGROUND:The high mortality associated with ovarian carcinoma is largely a reflection of the inability to diagnose the disease at an early stage; the identification of a histologic lesion or molecular marker associated early stages of transformation would represent an important advance in understanding the natural hi...


    pub_type: 杂志文章


    authors: Barakat RR,Federici MG,Saigo PE,Robson ME,Offit K,Boyd J

    更新日期:2000-07-15 00:00:00

  • Preoperative and postoperative immunological evaluation of patients with colorectal cancer.

    abstract::Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B...


    pub_type: 杂志文章


    authors: Shafir M,Bekesi JG,Papatestas A,Slater G,Aufses AH Jr

    更新日期:1980-08-15 00:00:00

  • An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma.

    abstract:BACKGROUND:An Investigational New Drug (IND) treatment program allows patients access to a drug that has shown activity against a serious or life-threatening disease prior to full Food and Drug Administration (FDA) review and approval. This treatment IND program, in which patients with locally advanced or metastatic pa...


    pub_type: 杂志文章


    authors: Storniolo AM,Enas NH,Brown CA,Voi M,Rothenberg ML,Schilsky R

    更新日期:1999-03-15 00:00:00

  • Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials.

    abstract::The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001...


    pub_type: 临床试验,杂志文章


    authors: Davis S,Wright PW,Schulman SF,Hill LD,Pinkham RD,Johnson LP,Jones TW,Kellogg HB Jr,Radke HM,Sikkema WW

    更新日期:1985-10-01 00:00:00

  • The effect of tumor necrosis factor on normal human hematopoietic progenitors.

    abstract::Tumor necrosis factor-alpha (TNF-alpha), a product of activated macrophages that is cytotoxic to tumor cells, could be used to purge tumor cells from bone marrow before autologous bone marrow transplantation for hematologic malignancies and/or solid tumors. To determine whether exposure to TNF-alpha would have an inhi...


    pub_type: 杂志文章


    authors: Abboud SL,Gerson SL,Berger NA

    更新日期:1987-12-15 00:00:00

  • Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial.

    abstract:BACKGROUND:Microphthalmia transcription factor (MITF)-associated (MiT) tumors are a family of rare malignancies, including alveolar soft part sarcoma (ASPS), clear cell sarcoma (CCS), and translocation-associated renal cell carcinoma (tRCC) that have dysregulated expression of oncogenic MITF family proteins. The MET re...


    pub_type: 杂志文章,多中心研究


    authors: Wagner AJ,Goldberg JM,Dubois SG,Choy E,Rosen L,Pappo A,Geller J,Judson I,Hogg D,Senzer N,Davis IJ,Chai F,Waghorne C,Schwartz B,Demetri GD

    更新日期:2012-12-01 00:00:00

  • Effect of human leukocyte interferon on malignant brain tumors.

    abstract::The antitumor effect of human leukocyte interferon was investigated on ten patients with malignant brain tumor. In eight cases of primary tumor, IFN alone was administered when their recurrent sign was evident. A dose of 3 X 10(6) IU or 1 X 10(6) IU of IFN was injected intramuscularly two or three times a week in high...


    pub_type: 杂志文章


    authors: Hirakawa K,Ueda S,Nakagawa Y,Suzuki K,Fukuma S,Kita M,Imanishi J,Kishida T

    更新日期:1983-06-01 00:00:00

  • Acute and delayed nausea and emesis control in pediatric oncology patients.

    abstract:BACKGROUND:To the authors' knowledge there is little information available regarding the effectiveness of standard antiemetic therapy among cancer patients who receive emetogenic chemotherapy in clinical practice, especially in the pediatric population. The current study was undertaken to determine the effectiveness of...


    pub_type: 杂志文章


    authors: Holdsworth MT,Raisch DW,Frost J

    更新日期:2006-02-15 00:00:00

  • Thin-needle aspiration biopsy: the diagnosis of head and neck tumors revisited.

    abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...


    pub_type: 杂志文章


    authors: Frable WJ,Frable MA

    更新日期:1979-04-01 00:00:00

  • Cost-effectiveness of human papillomavirus vaccination for adolescent girls in Punjab state: Implications for India's universal immunization program.

    abstract:BACKGROUND:Introduction of human papillomavirus (HPV) vaccination for adolescent girls is being considered in the Punjab state of India. However, evidence regarding cost-effectiveness is sought by policy makers when making this decision. The current study was undertaken to evaluate the incremental cost per quality-adju...


    pub_type: 杂志文章


    authors: Prinja S,Bahuguna P,Faujdar DS,Jyani G,Srinivasan R,Ghoshal S,Suri V,Singh MP,Kumar R

    更新日期:2017-09-01 00:00:00

  • An era of therapeutic translation.

    abstract::Diagnostic advances currently have exceeded therapeutic gain. The present, however, is a transition phase. Chemotherapy, for example, has become curative for some tumors in recent years, rather than merely palliative, due to the precision permitted by advances in molecular biology. At this time, acceleration in the ba...


    pub_type: 杂志文章


    authors: Gusberg SB

    更新日期:1987-10-15 00:00:00

  • Risk factors for hepatocellular carcinoma by age, sex, and liver disorder status: A prospective cohort study in Korea.

    abstract:BACKGROUND:To the authors' knowledge, relatively little is known regarding the interaction of risk factors for hepatocellular carcinoma (HCC) with age, sex, and liver disorder status. METHODS:The authors followed 504,646 Korean patients aged 40 to 80 years who underwent routine health checkups between 2002 and 2003 un...


    pub_type: 杂志文章


    authors: Yi SW,Choi JS,Yi JJ,Lee YH,Han KJ

    更新日期:2018-07-01 00:00:00

  • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study.

    abstract:BACKGROUND:Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters. METHODS:A total of 170 patients with...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kantarjian H,Issa JP,Rosenfeld CS,Bennett JM,Albitar M,DiPersio J,Klimek V,Slack J,de Castro C,Ravandi F,Helmer R 3rd,Shen L,Nimer SD,Leavitt R,Raza A,Saba H

    更新日期:2006-04-15 00:00:00

  • Randomized trial comparing cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) with rotational CMF, epirubicin and vincristine as primary chemotherapy in operable breast carcinoma.

    abstract:BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Cocconi G,Di Blasio B,Boni C,Bisagni G,Ceci G,Rondini E,Bella M,Leonardi F,Savoldi L,Camisa R,Bruzzi P

    更新日期:2002-07-15 00:00:00

  • Changes in serum levels of Forssman-like antibody in patients with gastric cancer.

    abstract::Because Forssman antigen, one of the most well-known heteroantigens, has been noted in certain cancerous tissues, it would seem that the serum levels of the Forssman antibody of patients with these cancers would be low, owing to the absorption of the naturally occurring antibody by the Forssman antigen-containing canc...


    pub_type: 杂志文章


    authors: Hirayama R,Hirokawa K,Takagi Y,Utsuyama M,Maejima S,Takemura K,Mishima Y,Makinodan T

    更新日期:1989-04-15 00:00:00

  • Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma.

    abstract::A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci...


    pub_type: 杂志文章


    authors: Dayal Y,Tashjian AH Jr,Wolfe HJ

    更新日期:1979-04-01 00:00:00

  • ThinPrep Pap Test: performance and biopsy follow-up in a university hospital.

    abstract:BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...


    pub_type: 杂志文章


    authors: Carpenter AB,Davey DD

    更新日期:1999-06-25 00:00:00

  • Improving cancer-specific outcomes in solid organ transplant recipients: Where to begin?

    abstract::In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...


    pub_type: 评论,杂志文章


    authors: Koff JL,Waller EK

    更新日期:2019-03-15 00:00:00

  • Multiple myeloma associated with immune thrombocytopenic purpura.

    abstract::Thrombocytopenia in patients with multiple myeloma is usually due to chemotherapy or marrow replacement with myeloma cells. Two patients with multiple myeloma who fulfilled criteria for the diagnosis of immune thrombocytopenic purpura are presented. The etiologic and therapeutic implications of this unusual associatio...


    pub_type: 杂志文章


    authors: Verdirame JD,Feagler JR,Commers JR

    更新日期:1985-09-01 00:00:00