Clinical application of intratumoral blood flow study in patients with endometrial carcinoma.

Abstract:

BACKGROUND:The objective of this study was to evaluate the correlation between intratumoral blood flow as assessed by color Doppler ultrasound with stage, tumor grade, depth of invasion, and lymph node metastasis in endometrial carcinoma and determine its clinical usefulness. METHODS:Sixty-six patients with endometrial carcinoma were enrolled. All patients received surgical treatment. Transvaginal color Doppler ultrasound was performed before surgery to detect the arterial blood flow signals within the tumors and the lowest resistance index (RI) was recorded. Formalin fixed, paraffin embedded pathology slides were reviewed by a senior pathologist to evaluate the histologic grading, tumor size, depth of myometrial invasion, and presence of lymph node metastasis. RESULTS:Intratumoral RI correlated well with surgical staging, histologic grading, the depth of myometrial invasion, and the presence of lymph node metastasis. Significantly lower RI was noted in tumors of advanced stage (> than International Federation of Obstetrics and Gynecology [FIGO] Stage I) (0.38 +/- 0.09 vs. 0.54 +/- 0.11; P < 0.001), tumors with higher histologic grade (Grade 3) (0.36 +/- 0.08 vs. 0.53 +/- 0.11; P < 0.001), tumors with deep myometrial invasion (> 50% myometrial thickness) (0.38 +/- 0.07 vs. 0.54 +/- 0.11; P < 0.001), and tumors with lymph node metastasis (0.34 +/- 0.07 vs. 0.52 +/- 0.11; P < 0.001) compared with tumors with Stage I, Grade 1/2 histology, no or superficial myometrial invasion, and absence of lymph node metastasis, respectively. CONCLUSIONS:Intratumoral blood flow analysis assessed by color Doppler ultrasound correlates well with surgical stage, tumor grade, myometrial invasion, and lymph node metastasis in patients with endometrial carcinoma. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, histologic grade, depth of myometrial invasion, and presence of lymph node metastasis in patients with endometrial carcinoma. The authors believe routine pelvic lymph node dissection should be performed for those patients whose lowest RI values of intratumoral blood flow are < or = 0.4 because those patients are at very high risk for pelvic lymph node involvement.

journal_name

Cancer

journal_title

Cancer

authors

Cheng WF,Chen TM,Chen CA,Wu CC,Huang KT,Hsieh CY,Hsieh FJ

subject

Has Abstract

pub_date

1998-05-15 00:00:00

pages

1881-6

issue

10

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19980515)82:10<1881::AID-C

journal_volume

82

pub_type

临床试验,杂志文章

相关文献

CANCER文献大全
  • Global, regional, and national burden of lung cancer and its attributable risk factors, 1990 to 2017.

    abstract:BACKGROUND:China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a uni...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33078

    authors: Wang N,Mengersen K,Tong S,Kimlin M,Zhou M,Hu W

    更新日期:2020-09-15 00:00:00

  • Transgenic models for the study of prostate cancer.

    abstract::Transgenic model systems provide tools for obtaining information that clarifies important relationships between genetic alterations and carcinogenesis. One such relationship is the induction of specific growth factor activities by dominantly acting oncogenes. Using a "transgenic organ" model referred to as mouse prost...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930201)71:3+<1165::aid-cncr282

    authors: Thompson TC,Truong LD,Timme TL,Kadmon D,McCune BK,Flanders KC,Scardino PT,Park SH

    更新日期:1993-02-01 00:00:00

  • Improvement in protection against adenocarcinoma of the cervix resulting from participation in cervical screening.

    abstract:BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11835

    authors: Mitchell H,Hocking J,Saville M

    更新日期:2003-12-25 00:00:00

  • Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.

    abstract:BACKGROUND:Ligand activation of peroxisome proliferator-activated receptor gamma (PPARgamma) results in the inhibition of proliferation of various cancer cells. The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglita...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10906

    authors: Yoshizawa K,Cioca DP,Kawa S,Tanaka E,Kiyosawa K

    更新日期:2002-11-15 00:00:00

  • Combined therapy for metastatic extradural tumors of the spine.

    abstract::The effectiveness of combined modality therapy was studied in 29 patients with metastatic extradural spinal tumor who had had a previous diagnosis of malignancy. Dexamethasone was begun upon suspicion of the diagnosis in a dose of 40 mg daily. Following emergency myelography, in all patients without rapid progression,...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(197711)40:5<2067::aid-cncr282040

    authors: Marshall LF,Langfitt TW

    更新日期:1977-11-01 00:00:00

  • Hormone receptor status of breast tumors in black, Hispanic, and non-Hispanic white women. An analysis of 13,239 cases.

    abstract:BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1465::AID-CN

    authors: Gapstur SM,Dupuis J,Gann P,Collila S,Winchester DP

    更新日期:1996-04-15 00:00:00

  • Measuring cardiopulmonary complications of carfilzomib treatment and associated risk factors using the SEER-Medicare database.

    abstract:BACKGROUND:Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32601

    authors: Fakhri B,Fiala MA,Shah N,Vij R,Wildes TM

    更新日期:2020-02-15 00:00:00

  • Histopathologic grading and DNA ploidy in relation to survival among 206 adult astrocytic tumor patients.

    abstract:BACKGROUND:The authors studied the benefit of performing histopathologic grading and DNA ploidy characterization with respect to patient survival in a series of 206 astrocytomas (AST) for which they obtained 134 complete clinical follow-ups. METHODS:The material analyzed came from archival material, i.e., formalin-fix...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920715)70:2<538::aid-cncr28207

    authors: Salmon I,Kiss R,Dewitte O,Gras T,Pasteels JL,Brotchi J,Flament-Durand J

    更新日期:1992-07-15 00:00:00

  • Intralesional radioimmunotherapy of malignant gliomas. An effective treatment in recurrent tumors.

    abstract:BACKGROUND:Intralesional radioimmunotherapy (RAIT) may improve the management of malignant gliomas whose prognosis is, at present, very poor. Current treatment modalities (e.g., surgery, radiotherapy, and chemotherapy) may prolong survival by a few months but cannot prevent tumor recurrence. METHODS:Following one or m...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940201)73:3+<1076::aid-cncr282

    authors: Riva P,Arista A,Tison V,Sturiale C,Franceschi G,Spinelli A,Riva N,Casi M,Moscatelli G,Frattarelli M

    更新日期:1994-02-01 00:00:00

  • Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients.

    abstract:BACKGROUND:It is unclear whether new treatment modalities have improved the survival of follicular lymphoma patients. Some data show that there has been no improvement in survival in the last 3 decades of the 20th century, whereas the results of recent retrospective studies suggest that evolving therapy has improved th...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22649

    authors: Sacchi S,Pozzi S,Marcheselli L,Bari A,Luminari S,Angrilli F,Merli F,Vallisa D,Baldini L,Brugiatelli M,Italian Lymphoma Study Group.

    更新日期:2007-05-15 00:00:00

  • Polymorphonuclear neutrophil function in malignant lymphomas and effects of splenectomy.

    abstract::Granulocyte (PMN) directional locomotion (migration) in vitro and in vivo, resting nitroblue tetrazolium (NBT)-reduction and adherence to nylon wool of polymorphonuclear neutrophils (PMN) were assayed in 7 patients with Hodgkin's disease (HD) and in 11 patients with non-Hodgkin's lymphoma (NHL) prior to therapy. In mo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800201)45:3<469::aid-cncr28204

    authors: Von Fliedner V,Salvatori V,Higby DJ,Stutzman L,Park BH

    更新日期:1980-02-01 00:00:00

  • N-terminal peptide of type III procollagen: a possible predictor of colorectal carcinoma recurrence.

    abstract:BACKGROUND:The first step of colorectal carcinoma spread depends on the ability of the tumor cells to degrade and invade the extracellular matrix (ECM). The objectives of the current study were to evaluate the serum pattern of laminin, C-terminal peptide of Type I (PIP), and N-terminal peptide of Type III (PIIIP) proco...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19970401)79:7<1299::aid-cn

    authors: Plebani M,Basso D,Roveroni G,De Paoli M,Galeotti F,Corsini A

    更新日期:1997-04-01 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00

  • Enrollment on clinical trials does not improve survival for children with acute myeloid leukemia: A population-based study.

    abstract:BACKGROUND:It is questionable whether enrollment on clinical trials offers any survival advantage at the population level over standard-of-care treatment. The objectives of this study were to describe the impact of trial enrollment on event-free survival and overall survival in pediatric acute myeloid leukemia (AML) us...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31728

    authors: Truong TH,Pole JD,Barber R,Dix D,Kulkarni KP,Martineau E,Randall A,Stammers D,Strahlendorf C,Strother D,Sung L

    更新日期:2018-10-15 00:00:00

  • Vitiligo autoantibodies are effective against melanoma.

    abstract:BACKGROUND:Vitiligo is a dermatologic disease characterized by local, dispersed, or diffuse white patches on the skin. The disease is defined as an autoimmune disorder because autoantibodies against membranal components of melanocytes are found in the patients' sera. The current study examined whether the autoantibodie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931015)72:8<2365::aid-cncr2820

    authors: Fishman P,Azizi E,Shoenfeld Y,Sredni B,Yecheskel G,Ferrone S,Zigelman R,Chaitchik S,Floro S,Djaldetti M

    更新日期:1993-10-15 00:00:00

  • An animal model for chemotherapy-associated steatohepatitis and its prevention by the oral administration of fatty acid bile acid conjugate.

    abstract:BACKGROUND:Preoperative chemotherapy for hepatic resection of colorectal liver metastases is associated with the development of chemotherapy-associated steatohepatitis (CASH). This increases the risk of perioperative morbidity and mortality. To the authors' knowledge, an animal model for CASH has not been described pre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24710

    authors: Keizman D,Maimon N,Ish-Shalom M,Buchbut D,Inbar M,Klein B,Bernheim J,Goldiner I,Leikin-Frenkel A,Konikoff F

    更新日期:2010-01-01 00:00:00

  • Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation.

    abstract::The growth rates of recurrent hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLTX) were estimated by calculating the tumor doubling time (TDT) in 20 patients. The mean TDT, calculated by multiple measurement of tumor size, was 44.3 +/- 11.3 days (mean +/- standard error) in 12 patients with pul...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911115)68:10<2095::aid-cncr282

    authors: Yokoyama I,Carr B,Saitsu H,Iwatsuki S,Starzl TE

    更新日期:1991-11-15 00:00:00

  • Strategies to overcome barriers to early detection of cancer among older adults.

    abstract::If health professionals wish to help increase the number of older adults who get screened regularly to detect cancer at an early stage, they must first understand the barriers to screening that older people experience. This paper discusses the barriers older women face regarding mammography screening. Data from Americ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941001)74:7+<2190::aid-cncr282

    authors: Rubenstein L

    更新日期:1994-10-01 00:00:00

  • The seventies evolution in liver surgery for cancer.

    abstract::During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810501)47:9<2162::aid-cncr2820

    authors: Fortner JG,MacLean BJ,Kim DK,Howland WS,Turnbull AD,Goldiner P,Carlon G,Beattie EJ Jr

    更新日期:1981-05-01 00:00:00

  • Effectiveness of high-dose MCNU therapy and hematopoietic stem cell autografts treatment of childhood acute leukemia/lymphoma with high-risk features.

    abstract::Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated wit...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910401)67:7<1830::aid-cncr2820

    authors: Takaue Y,Watanabe T,Hoshi Y,Abe T,Matsunaga K,Saito S,Hirao A,Kawano Y,Ninomiya T,Kuroda Y

    更新日期:1991-04-01 00:00:00

  • Recovery from aspermia induced by low-dose radiation in seminoma patients.

    abstract::Gonadal dosimetry and spermatogenic activity was monitored in patients given radiation therapy (RT) after unilateral orchiectomy for seminoma. The RT given was, with minor variations, 3200 rad in 16 fractions in four weeks to the para-aortic and ipsilateral pelvic inguinal lymphatics in order to include the orchiectom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820715)50:2<337::aid-cncr28205

    authors: Hahn EW,Feingold SM,Simpson L,Batata M

    更新日期:1982-07-15 00:00:00

  • Endoscopic ultrasound-guided fine-needle aspiration biopsy of the adrenal glands: analysis of 24 patients.

    abstract:BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy allows the detailed imaging and FNA not only of both intramural and extramural structures and lesions of the gastrointestinal (GI) tract but also of various intraabdominal organs. Thus, EUS-FNA biopsy offers a novel opportunity to evaluate ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20498

    authors: Jhala NC,Jhala D,Eloubeidi MA,Chhieng DC,Crowe DR,Roberson J,Eltoum I

    更新日期:2004-10-25 00:00:00

  • Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.

    abstract:BACKGROUND:To eliminate cranial irradiation (CrRT)-related sequelae and to minimize the adverse impact of traumatic lumbar puncture (TLP) with blasts, the Taiwan Pediatric Oncology Group (TPOG) introduced a modified central nervous system (CNS)-directed regimen characterized by delayed triple intrathecal therapy (TIT) ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.31758

    authors: Yeh TC,Liang DC,Hou JY,Jaing TH,Lin DT,Yang CP,Peng CT,Hung IJ,Lin KH,Hsiao CC,Jou ST,Chiou SS,Chen JS,Wang SC,Chang TK,Wu KH,Sheen JM,Yen HJ,Chen SH,Lu MY,Li MJ,Chang TT,Huang TH,Chang YH,Chen SH,Yang Y

    更新日期:2018-12-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: a population-based case-control study.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are involved in carcinogenesis. Therefore, the authors of this report examined the association between NSAID use and the risk of squamous cell carcinoma (SCC), basal cell carc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27406

    authors: Johannesdottir SA,Chang ET,Mehnert F,Schmidt M,Olesen AB,Sørensen HT

    更新日期:2012-10-01 00:00:00

  • The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site.

    abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22410

    authors: Sève P,Billotey C,Broussolle C,Dumontet C,Mackey JR

    更新日期:2007-01-15 00:00:00

  • Mental disorders in cancer patients: a study of 100 psychiatric referrals.

    abstract::Records of 100 consecutive hospitalized cancer patients referred for psychiatric consultation were reviewed. These patients constituted only 5% of those seen by the Psychiatry Consultation Service during the study period. Fifty-six percent of the referred patients were diagnosed as depressed and 40% as having organic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3<1385::aid-cncr282042

    authors: Levine PM,Silberfarb PM,Lipowski ZJ

    更新日期:1978-09-01 00:00:00

  • Systemic giant-cell histiocytosis: report of a case and a review of the adult form of Letterer-Siwe disease.

    abstract::The multiple classifications of histiocytic disorders, and the lack of specificity in their application, have degraded the utility of such diagnostic terms as "Letterer-Siwe Disease" and "Malignant Histiocytosis". A case is presented of a systemic histiocytic proliferation with erythrophagocytosis and giant-cell forma...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197612)38:6<2529::aid-cncr282038

    authors: Wolfson WL,Gossett T,Pagani J

    更新日期:1976-12-01 00:00:00

  • The impact of pulmonary infections on the survival of lung cancer patients.

    abstract::To determine the impact of pulmonary infections on survival in patients with lung cancer, a retrospective review of the records of 121 such patients treated at Howard University Hospital in Washington, DC, was done. There were 77 men and 44 women; 118 were black. The mean age was 63.5 years. Forty-three patients had s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900801)66:3<593::aid-cncr28206

    authors: Perlin E,Bang KM,Shah A,Hursey PD,Whittingham WL,Hashmi K,Campbell L,Kassim OO

    更新日期:1990-08-01 00:00:00

  • Comparative genomic hybridization analysis of genetic aberrations associated with development and progression of biliary tract carcinomas.

    abstract:BACKGROUND:Little is known about genetic aberrations associated with development and progression of biliary tract carcinomas. METHODS:To study chromosomal aberrations associated with development and progression of biliary tract carcinomas, the authors used comparative genomic hybridization to examine 50 such carcinoma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010201)91:3<570::aid-cncr1036>

    authors: Shiraishi K,Okita K,Harada T,Kusano N,Furui T,Kondoh S,Oga A,Kawauchi S,Fukumoto Y,Sasaki K

    更新日期:2001-02-01 00:00:00

  • Adenocarcinoma of prostate presenting as brain metastasis.

    abstract::The diagnosis of brain metastasis from prostate carcinoma is rarely made antemortem, and has previously been reported only in patients with known extensive metastatic disease of long duration. A case of adenocarcinoma of the prostate presenting as a brain metastasis is described. Current concepts of metastatic spread ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1723::aid-cncr2820

    authors: Baumann MA,Holoye PY,Choi H

    更新日期:1984-10-15 00:00:00