Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates.

Abstract:

:Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger than 1 ml. Eleven untrimmed prostates weighed 80 g or more and eight had elevated PSA levels (more than 4.0 ng/ml): five of eight without CAP, two of two with CAP less than 1 ml, and one of one with CAP larger than 1 ml. Ninety-four whole untrimmed prostates weighed less than 80 g and 20 had elevated PSA levels: ten of 60 without CAP, two of 26 with CAP less than 1 ml, and eight of eight with CAP larger than 1 ml. This study suggests that PSA levels from patients with untrimmed prostates weighing 80 g or more (equivalent to a 60-g trimmed prostate) are usually elevated regardless whether CAP is present. However, CAP less than 1 ml, in untrimmed prostates less than 80 g, usually does not elevate PSA levels whereas CAP larger than 1 ml usually does (P less than 0.0001). The likelihood that elevated PSA levels, from patients with untrimmed prostates less than 80 g, are due to CAP larger than 1 ml increases as the PSA level increases.

journal_name

Cancer

journal_title

Cancer

authors

Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

doi

10.1002/1097-0142(19911001)68:7<1592::aid-cncr2820

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1592-9

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

68

pub_type

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