Immunocytochemical detection using CDX2: An aid for discerning tumor involvement in ascites cytology.

Abstract:

BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distribution of CDX2 expression in carcinoma specimens using paraffin-embedded tissues from various organs from 549 cancer patients. CDX2 immunostaining was applied to the 116 ascites specimens. RESULTS:CDX2 expression was detected in a restricted range of cancers, with the vast majority of them originating from the gastrointestinal tract and pancreas. When applied to ascites specimens, no positive reactions were detected in any of the 81 cytology-negative and molecular genetic analysis-negative specimens. By contrast, 28 of 35 specimens diagnosed as suspicious for malignancy or malignancy showed a positive reaction. Furthermore, the authors found that a nuclear-positive reaction was easily evaluated, even with a high level of background staining, and single cancer cells in 10(6) normal cells could be detected. CONCLUSION:Results suggest that CDX2 is a specific and sensitive marker to detect gastrointestinal and pancreatic malignancies in ascites cytology.

journal_name

Cancer

journal_title

Cancer

authors

Kobayashi M,Ueyama Y,Nakanishi H,Ishida H,Takahashi E,Nakamura S,Koshikawa T,Yatabe Y

doi

10.1002/cncr.21840

subject

Has Abstract

pub_date

2006-04-25 00:00:00

pages

114-8

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

108

pub_type

杂志文章

相关文献

CANCER文献大全
  • Alternative bimonthly cycles of doxorubicin, cyclophosphamide, and etoposide, cisplatin with hematopoietic growth factor support in patients with carcinoma of unknown primary site.

    abstract:BACKGROUND:Because carcinomas of unknown primary origin are highly malignant tumors with a bad prognosis (median survival, 6-12 months) and no current optimal therapy, the authors designed a prospective dose-dense chemotherapy regimen with the objective of improving the results observed in patients who receive conventi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.10264

    authors: Culine S,Fabbro M,Ychou M,Romieu G,Cupissol D,Pinguet F

    更新日期:2002-02-01 00:00:00

  • Focal nodular hyperplasia of the liver: report of six patients. Concepts of surgical management.

    abstract::The authors add six patients with focal nodular hyperplasia of the liver to the increasing number reported. All had ingested hormones as contraceptives for periods of from one and one-half to seven years. In five patients, the initial manifestation was massive intraabdominal hemorrhage and hypovolemic shock. Five of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<587::aid-cncr2820390

    authors: Catalano PW,Early ME,Topolosky HW,Martin EW Jr,Carey LC

    更新日期:1977-02-01 00:00:00

  • Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.

    abstract::The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases reve...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900715)66:2<289::aid-cncr28206

    authors: Kobayashi T,Tsuda H,Noguchi M,Hirohashi S,Shimosato Y,Goya T,Hayata Y

    更新日期:1990-07-15 00:00:00

  • Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas.

    abstract:BACKGROUND:Despite optimal therapy with surgery and radiotherapy, the prognosis of patients with glioblastomas remains poor. Stereotactic brachytherapy involves the accurate placement of radioactive isotopes within brain tumors, significantly increasing the dose of radiation that can be delivered to the tumor bed witho...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940615)73:12<3029::aid-cncr282

    authors: Wen PY,Alexander E 3rd,Black PM,Fine HA,Riese N,Levin JM,Coleman CN,Loeffler JS

    更新日期:1994-06-15 00:00:00

  • Spontaneous remission in adult acute leukemia.

    abstract::A spontaneous complete remission of 34 months' duration was observed in an adult patient with acute myeloblastic leukemia. The remission occurred after a severe febrile pneumonia, which was treated with leukocyte transfusions. At relapse, chromosomal abnormalities reappeared slowly. Such spontaneous complete remission...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850901)56:5<1187::aid-cncr2820

    authors: Ifrah N,James JM,Viguie F,Marie JP,Zittoun R

    更新日期:1985-09-01 00:00:00

  • An assessment of World Health Organization criteria for severe acute respiratory syndrome in patients with cancer.

    abstract:BACKGROUND:The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20141

    authors: Gu J,Wu A,Li J,Zhang X,Fang J,Li M,Yao Y,Ke Y,Gu J,Chen M,You W

    更新日期:2004-04-01 00:00:00

  • Prolonged remissions in adults with acute leukemia following late intensification chemotherapy and immunotherapy.

    abstract::Sixty-two patients with acute leukemia who remained in continuous complete remission for 8 to 45 months received three courses of intensified therapy with new chemotherapeutic agents, after which they received no further chemotherapy. Immunotherapy with BCG was then administered to 55 of these patients. They have been...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810415)47:8<1937::aid-cncr2820

    authors: Bodey GP,Freireich EJ,McCredie KB,Smith TL,Gehan EA,Gutterman JU,Hersh EM

    更新日期:1981-04-15 00:00:00

  • Unusual clinical presentation of upper urothelial carcinoma in Taiwan.

    abstract:BACKGROUND:The unusual clinical picture of transitional cell carcinoma (TCC) in Taiwan appears to be different from that reported elsewhere. METHODS:The authors reviewed their experience of 135 cases of pathologically proven TCC of the upper urinary tract. Data regarding the gender ratio and clinical presentation were...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Chou YH,Huang CH

    更新日期:1999-03-15 00:00:00

  • Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels.

    abstract:BACKGROUND:The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma. METHODS:The following potential prognostic factors were retrospectively investigated in 124 patients treated with radi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20952

    authors: Rades D,Schild SE,Bahrehmand R,Zschenker O,Alberti WA,Rudat VR

    更新日期:2005-04-15 00:00:00

  • Accumulation of DNA methylation is associated with tumor stage in gastric cancer.

    abstract:BACKGROUND:The authors purpose in this study was to clarify the difference in terms of clinicopathologic features between gastric cancer (GC) with high numbers of DNA methylated genes and CpG island methylator phenotype (CIMP)-positive GC as originally defined. METHODS:We analyzed DNA methylation of 12 tumor-related g...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21754

    authors: Oue N,Mitani Y,Motoshita J,Matsumura S,Yoshida K,Kuniyasu H,Nakayama H,Yasui W

    更新日期:2006-03-15 00:00:00

  • Giant cell tumor in Paget's disease of bone: familial and geographic clustering.

    abstract::Four patients with benign giant cell tumor and one patient with probable benign giant cell tumor associated with Paget's disease of bone are reported. The familial and geographic clustering of these cases is unique in that three patients were related and all patients traced ancestral roots to the same area of southern...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197908)44:2<742::aid-cncr2820440

    authors: Jacobs TP,Michelsen J,Polay JS,D'Adamo AC,Canfield RE

    更新日期:1979-08-01 00:00:00

  • Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.

    abstract::The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated. There were 17 patients with acute myelogenous leukemia (AML), six with acute lymphocytic leukemia (ALL), and one with biphenotypic leukemia. In this series of 24 patients whose disease had relapsed and who ha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910915)68:6<1198::aid-cncr2820

    authors: Arlin ZA,Feldman EJ,Mittelman A,Ahmed T,Puccio C,Chun HG,Cook P,Baskind P,Marboe C,Mehta R

    更新日期:1991-09-15 00:00:00

  • Lymphocyte subpopulations in chronic lymphocytic leukemia detected by lectin binding and flow cytometry.

    abstract::Flow cytometry was used to compare binding of wheat germ agglutinin (WGA) and Lens culinaris lectin (Lcl) to peripheral lymphocytes (PBL) from normal subjects and 26 patients with chronic lymphocytic leukemia (CLL). As defined by the interactions of WGA and Lcl with cell surface receptors, normal unfractionated PBL an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830601)51:11<2083::aid-cncr282

    authors: Boldt DH,Nelson MO

    更新日期:1983-06-01 00:00:00

  • Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry.

    abstract:BACKGROUND:Hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) is an autosomal dominant disease characterized by early-onset intestinal neoplasms, localization of tumors in the proximal colon, and frequent association with cancers at other sites, especially the endometrium, skin, and stomach. The identi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930601)71:11<3493::aid-cncr282

    authors: Ponz de Leon M,Sassatelli R,Benatti P,Roncucci L

    更新日期:1993-06-01 00:00:00

  • General population norms for the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI).

    abstract:BACKGROUND:Metastatic renal cell cancer is associated with poor long-term survival and has no cure. Traditional clinical endpoints are best supplemented by patient-reported outcomes designed to assess symptoms and function. Normative data was obtained on the National Comprehensive Cancer Network-Functional Assessment o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27688

    authors: Butt Z,Peipert J,Webster K,Chen C,Cella D

    更新日期:2013-01-15 00:00:00

  • Women age < or = 35 years with primary breast carcinoma: disease features at presentation.

    abstract:BACKGROUND:The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival. METHODS:Four hundred fifty-two women age < or = 35 years with breast carci...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21070

    authors: Gonzalez-Angulo AM,Broglio K,Kau SW,Eralp Y,Erlichman J,Valero V,Theriault R,Booser D,Buzdar AU,Hortobagyi GN,Arun B

    更新日期:2005-06-15 00:00:00

  • Quality of life and symptoms in a randomized trial of radiotherapy versus deferred treatment of localized prostate carcinoma.

    abstract:BACKGROUND:Treatment of localized prostate carcinoma (LPC) using radiotherapy (RT) can induce disturbances in a patient's quality of life (QOL) and urinary and intestinal function. Late symptoms and QOL were evaluated in a randomized trial between RT and deferred treatment (DT). METHODS:Quality of life was evaluated w...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(20011215)92:12<3111::aid-cncr101

    authors: Fransson P,Damber JE,Tomic R,Modig H,Nyberg G,Widmark A

    更新日期:2001-12-15 00:00:00

  • Latent Epstein-Barr virus infection is an unlikely event in the pathogenesis of immunoproliferative small intestinal disease.

    abstract:BACKGROUND:The observed seasonal and geographic variations in the incidence of immunoproliferative small intestinal disease (IPSID) suggest that environmental factors contribute to its pathogenesis. One such environmental factor, the Epstein-Barr virus (EBV), has been associated with other B-cell lymphoproliferative di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940915)74:6<1699::aid-cncr2820

    authors: Baddoura FK,Unger ER,Mufarrij A,Nassar VH,Zaki SR

    更新日期:1994-09-15 00:00:00

  • Ethnic disparity in mortality after diagnosis of colorectal cancer among inner city minority New Yorkers.

    abstract:BACKGROUND:Ethnic disparities in colorectal cancer (CRC) mortality are observed in the United States. The authors studied this among minority New Yorkers with CRC. METHODS:In a study of CRC patients in a New York City teaching hospital, 5-year data on demographics and clinical features were reviewed. Adjusted cancer-r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24614

    authors: Kanna B,Narang TK,Atwal T,Paul D,Azeez S

    更新日期:2009-12-01 00:00:00

  • High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma.

    abstract::A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880815)62:4<686::aid-cncr28206

    authors: Siddiqui MZ,Von Eyben FE,Spanos G

    更新日期:1988-08-15 00:00:00

  • Barriers and incentives for primary care physicians in cancer prevention and detection.

    abstract::The American Cancer Society estimates that nearly a million new cases of cancer will occur and that approximately a half million lives will be lost in 1987. These figures may double by the year 2000 primarily because of our aging population, with age being the leading risk factor for cancer. It is believed that the ma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880601)61:11+<2382::aid-cncr28

    authors: Williams PA,Williams M

    更新日期:1988-06-01 00:00:00

  • Comparison of the working formulation of non-Hodgkin's lymphoma with the Rappaport, Kiel, and Lukes & Collins classifications. Translational value and prognostic significance based on review of 658 patients treated at a single institution.

    abstract::Six hundred fifty-eight cases of previously untreated non-Hodgkin's lymphoma seen between 1970 and 1979 at the Medical Department, the Finsen Institute, were the basis for a comparative study of the prognostic value of the Rappaport, Kiel, and Lukes & Collins classifications and the new translation system, the Working...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850515)55:10<2442::aid-cncr282

    authors: Ersbøll J,Schultz HB,Hougaard P,Nissen NI,Hou-Jensen K

    更新日期:1985-05-15 00:00:00

  • Disease control intervals in high-risk neuroblastoma.

    abstract:BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23507

    authors: Santana VM,Furman WL,McGregor LM,Billups CA

    更新日期:2008-06-15 00:00:00

  • Expression of beta1 and beta4 integrins in normal arachnoid membrane and meningiomas.

    abstract:BACKGROUND:The aim of this work was to study the expression of alpha, beta1, and beta4 integrin subunits in meningiomas. METHODS:Seventeen atypical or anaplastic meningiomas were retrieved from the files of Hôpital de Bellevue, Saint-Etienne, France. They were compared with 17 benign meningiomas consecutively examined...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Beschet I,Brunon J,Scoazec JY,Mosnier JF

    更新日期:1999-12-15 00:00:00

  • Sarcomas (other than Ewing's) of flat bones in children and adolescents. A clinicopathologic study.

    abstract::The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900215)65:4<1011::aid-cncr2820

    authors: Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

    更新日期:1990-02-15 00:00:00

  • The problem of neck relapse in early stage supraglottic larynx cancer.

    abstract::We reviewed the records of 104 patients with Stage T1NO or Stage T2NO epidermoid carcinoma of the supraglottic larynx treated between 1965 and 1979. In 79 patients, surgery was the only type of initial treatment. These 79 patients are the subjects of this report. Forty-eight (61%) of these patients were treated by tot...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890115)63:2<345::aid-cncr28206

    authors: Levendag P,Sessions R,Vikram B,Strong EW,Shah JP,Spiro R,Gerold F

    更新日期:1989-01-15 00:00:00

  • Evolution of the team approach in breast cancer.

    abstract::Dr. Wendell G. Scott hailed mammography as the first significant contribution to the control of breast cancer since Halsted described the radical mastectomy in 1903. Mammography as engendered new approaches and has supplied new concepts of breast cancer. Through the tenacity of a few physicians convinced something cou...

    journal_title:Cancer

    pub_type: 历史文章,杂志文章

    doi:10.1002/1097-0142(197511)36:5<1815::aid-cncr282036

    authors: Egan RL

    更新日期:1975-11-01 00:00:00

  • Prostatic cancer after prostatectomy for benign disease.

    abstract::Twenty of 391 newly diagnosed cases of prostatic cancer (5%) had a prior prostatectomy for benign disease. Digital rectal examination in 16 of 19 patients (84%) revealed a significant prostatic abnormality. Continued serial digital rectal examination should be performed routinely after prostatectomy for benign disease...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860815)58:4<994::aid-cncr28205

    authors: Schwartz I,Wein AJ,Malloy TR,Glick JH

    更新日期:1986-08-15 00:00:00

  • Malignant mixed tumor of the vagina probably arising in mesonephric rests.

    abstract::An exceedingly rare tumor arising in the upper lateral vagina is described histologically, histochemically, and ultrastructurally. It is compared to the lesion reported by Okagaki et al. which is considered to represent the same type of tumor. Comparison with synovial sarcomas indicates that the lesion is similar, but...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197807)42:1<214::aid-cncr2820420

    authors: Shevchuk MM,Fenoglio CM,Lattes R,Frick HC 2nd,Richart RM

    更新日期:1978-07-01 00:00:00

  • Critical evaluation of the role of nutritional support with chemotherapy.

    abstract::Although weight loss has an adverse impact on cancer patient survival, the ability of caloric provision via total parenteral nutrition (TPN) to favorably influence outcome in chemotherapy-treated populations is not established. In randomized trials, no significant improvement in either response or survival was associa...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/1097-0142(19850101)55:1+<268::aid-cncr2820

    authors: Chlebowski RT

    更新日期:1985-01-01 00:00:00