Accumulation of DNA methylation is associated with tumor stage in gastric cancer.

abstract：BACKGROUND:Introduction of human papillomavirus (HPV) vaccination for adolescent girls is being considered in the Punjab state of India. However, evidence regarding cost-effectiveness is sought by policy makers when making this decision. The current study was undertaken to evaluate the incremental cost per quality-adju...

journal_title：Cancer

authors： Prinja S,Bahuguna P,Faujdar DS,Jyani G,Srinivasan R,Ghoshal S,Suri V,Singh MP,Kumar R

更新日期：2017-09-01 00:00:00

abstract：:In January, 1972, the Southwest Oncology Group initiated two randomized studies for patients with advanced breast cancer. The study for patients with prior chemotherapy showed a 33% response rate with adriamycin. The study for patients without previous chemotherapy consisted of three treatment regimens; a weekly repea...

journal_title：Cancer

authors： Hoogstraten B,George SL,Samal B,Rivkin SE,Costanzi JJ,Bonnet JD,Thigpen T,Braine H

更新日期：1976-07-01 00:00:00

abstract：:At the Finsen Institute, Copenhagen, from 1971 to 1981, 134 patients were treated for lymph node metastases from primary cutaneous malignant melanoma of axial localization (e.g., in the head and neck and trunk), where metastases to regional lymph node groups were the first sign of dissemination. Due to the lack of suf...

journal_title：Cancer

authors： Lock-Andersen J,Partoft S,Jensen MG

更新日期：1988-11-01 00:00:00

abstract：:Four cases of non-Hodgkin's lymphoma (NHL) limited to the larynx are described. All were diffuse, high-grade, B-cell lymphomas of large lymphoid cell type (three centroblastic and one immunoblastic). Immunocytochemistry was performed on three cases; two showed monoclonal cytoplasmic immunoglobulin and one showed monoc...

journal_title：Cancer

authors： Morgan K,MacLennan KA,Narula A,Bradley PJ,Morgan DA

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population-based study of Detroit area men with localized PC to determine the outcome of bowel, urinary, and sexual ...

journal_title：Cancer

authors： Schwartz K,Bunner S,Bearer R,Severson RK

更新日期：2002-07-01 00:00:00

abstract：:Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...

journal_title：Cancer

authors： Poplack DG,Balis FM,Zimm S

更新日期：1986-07-15 00:00:00

abstract：:The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macrom...

journal_title：Cancer

authors： Heidelberger C

更新日期：1977-07-01 00:00:00

abstract：:In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P ...

journal_title：Cancer

authors： Olsson H,Ranstam J,Baldetorp B,Ewers SB,Fernö M,Killander D,Sigurdsson H

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Esophageal carcinoma is a major cause of cancer-related deaths among males in Taiwan. However, to date, the genetic alterations that accompany this lethal disease are not understood. METHODS:Chromosomal aberrations of 46 samples of esophageal squamous cell carcinoma (EC-SCC) were analyzed by comparative gen...

journal_title：Cancer

authors： Yen CC,Chen YJ,Chen JT,Hsia JY,Chen PM,Liu JH,Fan FS,Chiou TJ,Wang WS,Lin CH

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS:The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study a...

journal_title：Cancer

authors： Boyapati SM,Shu XO,Gao YT,Cai Q,Jin F,Zheng W

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. METHODS:Based on inter...

journal_title：Cancer

authors： Fagioli F,Cuneo A,Piva N,Carli MG,Previati R,Balboni M,Tomasi P,Cariani D,Scapoli G,Castoldi G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The balance among cell proliferation, cell differentiation, and cell death determines the cell number in a population as well as the size or even the stage of a tumor. Thus, to improve our understanding of the pathogenesis of neoplasms, it is important to investigate the regulation of both cell proliferation...

journal_title：Cancer

authors： Shen KL,Harn HJ,Ho LI,Yu CP,Chiu SC,Lee WH

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a uni...

journal_title：Cancer

authors： Wang N,Mengersen K,Tong S,Kimlin M,Zhou M,Hu W

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Gastric carcinoma is one of the most common malignancies worldwide, with an overall survival of about 10%. Improvement in therapy awaits better understanding of the biologic behavior of this tumor. Establishment of cell lines permits detailed analysis of the biology of gastric cancer. The authors report on t...

journal_title：Cancer

authors： Altorki N,Schwartz GK,Blundell M,Davis BM,Kelsen DP,Albino AP

更新日期：1993-08-01 00:00:00

abstract：:Eighty-one female patients with phyllodes tumors of the breast, surgically treated from 1974 to 1983, were studied. Their age ranged from 9 to 88 years. According to histology, the series was divided into three groups, of 28 (34.5%) benign tumors, 32 (39.5%) border-line tumors, and 21 (25.9%) malignant tumors. Because...

journal_title：Cancer

authors： Salvadori B,Cusumano F,Del Bo R,Delledonne V,Grassi M,Rovini D,Saccozzi R,Andreola S,Clemente C

更新日期：1989-06-15 00:00:00

abstract：:Clinical, histological and ultrastructural features of three small cell carcinomas arising in the parotid gland are presented. The light microscopic appearance of two of the neoplasms suggested neuroendocrine cell derivation, confirmed by electron microscopy in both instances. The fine structure of the third neoplasm ...

journal_title：Cancer

authors： Kraemer BB,Mackay B,Batsakis JG

更新日期：1983-12-01 00:00:00

abstract：:This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...

journal_title：Cancer

authors： Wahl RL

更新日期：1994-02-01 00:00:00

abstract：:External-beam irradiation of prostatic cancer was introduced at Stanford in 1956. The program has sought to determine the following: whether prostatic carcinoma can be cured by external beam radiation therapy, with what frequency this can be accomplished, which patients are best suited for irradiation, and what techni...

journal_title：Cancer

authors： Bagshaw MA,Ray GR,Cox RS

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs). METHODS:The authors describe the incidence of solid organ SMN in survi...

journal_title：Cancer

authors： Goldsby R,Burke C,Nagarajan R,Zhou T,Chen Z,Marina N,Friedman D,Neglia J,Chuba P,Bhatia S

更新日期：2008-11-01 00:00:00

abstract：:With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients w...

journal_title：Cancer

authors： Wallace WH

更新日期：2011-05-15 00:00:00

abstract：:Ultrasonographic examinations and measurements of CA 19-9 and elastase 1 were done simultaneously in 14 patients with resectable pancreatic cancer of less than 3.0 cm in longest diameter and 48 patients with pancreatitis. Although a pancreatic mass was detected ultrasonically in only six (42.9%) of the patients with t...

journal_title：Cancer

authors： Iishi H,Yamamura H,Tatsuta M,Okuda S,Kitamura T

更新日期：1986-05-15 00:00:00

abstract：:The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and ...

journal_title：Cancer

authors： Hustinx TW,Burghouts JT,Scheres JM,Smits AP

更新日期：1980-01-15 00:00:00

abstract：BACKGROUND:Preoperative chemoradiation improves survival in esophageal and gastroesophageal junction (GEJ) cancer. We evaluated irinotecan and cisplatin as induction chemotherapy followed by concurrent chemoradiation in esophageal cancer. METHODS:Patients with uT1N1M0 or uT2-4NanyM0 resectable squamous cancer or adeno...

journal_title：Cancer

authors： Ilson DH,Minsky BD,Ku GY,Rusch V,Rizk N,Shah M,Kelsen DP,Capanu M,Tang L,Campbell J,Bains M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine and compare the added prognostic value of screening tools, geriatric assessment (GA) components, and GA summaries to clinical information for overall survival (OS) in older patients with cancer. METHODS:A screening and a 10-item GA were systematically performed in pati...

journal_title：Cancer

authors： Kenis C,Baitar A,Decoster L,De Grève J,Lobelle JP,Flamaing J,Milisen K,Wildiers H

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The purpose of the current study was to test the hypothesis that a lower clinical TNM stage is associated with a higher rate of pathologic complete response (pathCR) in patients with esophageal carcinoma receiving preoperative chemoradiotherapy and to determine whether outcome after pathCR is related to clin...

journal_title：Cancer

authors： Rohatgi P,Swisher SG,Correa AM,Wu TT,Liao Z,Komaki R,Walsh GL,Vaporciyan AA,Rice DC,Roth JA,Ajani JA

更新日期：2005-12-01 00:00:00

abstract：:Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

journal_title：Cancer

authors： Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

更新日期：1980-09-15 00:00:00

abstract：:This clinicopathologic study concerns 27 cases of "dedifferentiated" soft tissue sarcoma (DSTS), including 14 liposarcomas, six leiomyosarcomas, five chondrosarcomas, and two rhabdomyosarcomas. In addition, the authors conducted an immunohistochemical survey of 23 cases and an electron microscopic examination of three...

journal_title：Cancer

authors： Hashimoto H,Daimaru Y,Tsuneyoshi M,Enjoji M

更新日期：1990-10-01 00:00:00

abstract：:Cis-diamminedichloride platinum II (DDP) was administered to eight patients with epidermoid carcinoma of the penis. Three of six adequately treated patients had an objective response: one patient achieved complete remission of 7 months duration and 2 patients had partial remissions of 8 and 2 months, respectively. DDP...

journal_title：Cancer

authors： Sklaroff RB,Yagoda A

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

journal_title：Cancer

authors： Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS:The association between lung carcinoma risk an...

journal_title：Cancer

authors： Muscat JE,Chen SQ,Richie JP Jr,Altorki NK,Citron M,Olson S,Neugut AI,Stellman SD

更新日期：2003-04-01 00:00:00