Cis-diamminedichloride platinum II (DDP) in the treatment of penile carcinoma.


:Cis-diamminedichloride platinum II (DDP) was administered to eight patients with epidermoid carcinoma of the penis. Three of six adequately treated patients had an objective response: one patient achieved complete remission of 7 months duration and 2 patients had partial remissions of 8 and 2 months, respectively. DDP appears to be an active agent in the treatment of penile carcinoma.






Sklaroff RB,Yagoda A




Has Abstract


1979-11-01 00:00:00














  • Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma.

    abstract:BACKGROUND:Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma remains to be elucidated. ...


    pub_type: 杂志文章


    authors: Nakamura S,Nakamura S,Matsumoto T,Yada S,Hirahashi M,Suekane H,Yao T,Goda K,Iida M

    更新日期:2005-11-01 00:00:00

  • Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma.

    abstract::Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate ...


    pub_type: 杂志文章


    authors: Creagan ET,Ingle JN,Ahmann DL,Green SJ

    更新日期:1982-04-01 00:00:00

  • BACON (bleomycin, adriamycin, CCNU, oncovin and nitrogen mustard) in squamous lung cancer. Experience in fifty patients.

    abstract::Fifty patients with inoperable squamous carcinoma of the lung. 38 with extensive, and 12 with limited disease, were treated with BACON. Tumor regression greater than 50% was observed in 17 patients (45%) with extensive, and four patients (33%) with limited disease. Stabilization of disease for greater than or equal to...


    pub_type: 临床试验,杂志文章


    authors: Livingston RB,Fee WH,Einhorn LH,Burgess MA,Freireich EJ,Gottlieb JA,Farber MO

    更新日期:1976-03-01 00:00:00

  • Testicular Cancer in Children.

    abstract::Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...


    pub_type: 杂志文章


    authors: Exelby PR

    更新日期:1980-04-01 00:00:00

  • Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma.

    abstract:BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patient...


    pub_type: 杂志文章


    authors: Chamberlain MC

    更新日期:1994-03-15 00:00:00

  • Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen.

    abstract::Two studies were performed to evaluate the safety, tolerability, and efficacy of irinotecan (CPT-11) in the treatment of adults with malignant glioma. Patients with progressive or recurrent malignant gliomas were enrolled. In the first study, CPT-11 was administered once every 3 weeks as a 90-minute intravenous infusi...


    pub_type: 杂志文章


    authors: Cloughesy TF,Filka E,Kuhn J,Nelson G,Kabbinavar F,Friedman H,Miller LL,Elfring GL

    更新日期:2003-05-01 00:00:00

  • Measuring response to BCR-ABL inhibitors in chronic myeloid leukemia.

    abstract::In patients with chronic myeloid leukemia (CML), the hallmark Philadelphia chromosome is the marker of disease that can be detected by conventional metaphase cytogenetics, fluorescence in situ hybridization, or polymerase chain reaction. The current "gold standard" of treatment response is cytogenetic response. Cytoge...


    pub_type: 杂志文章,评审


    authors: Radich JP

    更新日期:2012-01-15 00:00:00

  • The use of molecular assays to establish definitively the clonality of ipsilateral breast tumor recurrences and patterns of in-breast failure in patients with early-stage breast cancer treated with breast-conserving therapy.

    abstract:BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...


    pub_type: 杂志文章


    authors: Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

    更新日期:2007-04-01 00:00:00

  • Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.

    abstract:BACKGROUND:Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS:The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits...


    pub_type: 杂志文章


    authors: Zagzag D,Zhong H,Scalzitti JM,Laughner E,Simons JW,Semenza GL

    更新日期:2000-06-01 00:00:00

  • Primary splenic angiosarcoma. Case report and literature review.

    abstract::Primary splenic angiosarcomas are rare neoplasms. The diagnosis can only be made at surgery. Splenectomy prior to rupture prolongs survival. An unusual case report is presented and the literature reviewed. ...


    pub_type: 杂志文章


    authors: Smith VC,Eisenberg BL,McDonald EC

    更新日期:1985-04-01 00:00:00

  • Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma.

    abstract:BACKGROUND:Even when they are analogous in microscopic and macroscopic appearance, tumors vary in their response rates to radiotherapy. Cell culture and xenograft experiments with colorectal cell lines have demonstrated that wild-type p53 increases radiosensitivity. Hence, the authors investigated, in a well-defined po...


    pub_type: 杂志文章


    authors: Nehls O,Klump B,Holzmann K,Lammering G,Borchard F,Gruenagel HH,Gaco V,Gregor M,Porschen R

    更新日期:1999-06-15 00:00:00

  • Reserpine and breast cancer.

    abstract::After a series of studies on the linkage of reserpine with breast cancer, both evidence and interpretation appeared to be in conflict. Our case-control survey of long-term, comprehensive records from the Kaiser Foundation Medical Care Program, on 108 hypertensive breast cancer cases and 324 hypertensive controls, matc...


    pub_type: 杂志文章


    authors: Kodlin D,McCarthy N

    更新日期:1978-02-01 00:00:00

  • Increased lipid peroxidation in malignant tissues of patients with colorectal cancer.

    abstract::The authors investigated the level of lipid peroxidation and possible related phenomena in the activation of phospholipase A2 and the infiltration of granulocyte neutrophils in human colorectal cancer tissue samples. Malondialdehyde (an index of lipid peroxidation), phospholipase A2 activity, and myeloperoxidase activ...


    pub_type: 杂志文章


    authors: Otamiri T,Sjödahl R

    更新日期:1989-07-15 00:00:00

  • The role of the surgeon in whether patients with lymph node-positive colon cancer see a medical oncologist.

    abstract:BACKGROUND:Chemotherapy improves survival for patients with stage III colon cancer, but some older patients with lymph node-positive colon cancer do not see a medical oncologist and, thus, do not receive adjuvant chemotherapy. METHODS:To evaluate the role of the surgeon in determining referrals to medical oncology amo...


    pub_type: 杂志文章


    authors: Luo R,Giordano SH,Zhang DD,Freeman J,Goodwin JS

    更新日期:2007-03-01 00:00:00

  • Lung cancer mortality risk among breast cancer patients treated with anti-estrogens.

    abstract:BACKGROUND:The Women's Health Initiative randomized clinical trial reported that menopausal hormone therapy increases lung cancer mortality risk. If this is true, use of anti-estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast c...


    pub_type: 杂志文章


    authors: Bouchardy C,Benhamou S,Schaffar R,Verkooijen HM,Fioretta G,Schubert H,Vinh-Hung V,Soria JC,Vlastos G,Rapiti E

    更新日期:2011-03-15 00:00:00

  • Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy.

    abstract:BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...


    pub_type: 杂志文章


    authors: Hawkins DS,Arndt CA

    更新日期:2003-12-01 00:00:00

  • Randomized controlled trials of treatments for hematologic malignancies: study characteristics and outcomes.

    abstract:BACKGROUND:Although randomized controlled trials (RCTs) require a great deal of time, money, and effort, the majority of them have resulted in failure to verify a priori hypotheses. Therefore, the intention in the current study was to clarify the differential elements of studies with 'positive' and 'negative' outcomes....


    pub_type: 杂志文章


    authors: Yanada M,Narimatsu H,Suzuki T,Matsuo K,Naoe T

    更新日期:2007-07-15 00:00:00

  • Effects of hepatic arterial yttrium 90 glass microspheres in dogs.

    abstract::A 22-micron glass microsphere called TheraSphere (Theragenics Corp., Atlanta, GA) has been developed in which yttrium 89 oxide is incorporated into the glass matrix and is activated by neutron bombardment to form the beta-emitting isotope yttrium 90 (Y 90) before using the spheres as radiotherapeutic vehicles. The inj...


    pub_type: 杂志文章


    authors: Wollner I,Knutsen C,Smith P,Prieskorn D,Chrisp C,Andrews J,Juni J,Warber S,Klevering J,Crudup J

    更新日期:1988-04-01 00:00:00

  • Extranodal small lymphocytic proliferation: a clinicopathologic and immunocytochemical study.

    abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...


    pub_type: 杂志文章


    authors: Evans HL

    更新日期:1982-01-01 00:00:00

  • An animal model for chemotherapy-associated steatohepatitis and its prevention by the oral administration of fatty acid bile acid conjugate.

    abstract:BACKGROUND:Preoperative chemotherapy for hepatic resection of colorectal liver metastases is associated with the development of chemotherapy-associated steatohepatitis (CASH). This increases the risk of perioperative morbidity and mortality. To the authors' knowledge, an animal model for CASH has not been described pre...


    pub_type: 杂志文章


    authors: Keizman D,Maimon N,Ish-Shalom M,Buchbut D,Inbar M,Klein B,Bernheim J,Goldiner I,Leikin-Frenkel A,Konikoff F

    更新日期:2010-01-01 00:00:00

  • Binding of soybean agglutinin lectin to prostatic hyperplasia and adenocarcinoma.

    abstract::The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight ...


    pub_type: 杂志文章


    authors: Loy TS,Kyle J,Bickel JT

    更新日期:1989-04-15 00:00:00

  • Racial disparities in urologist visits among elderly men with prostate cancer: a cohort analysis of patient-related and county of residence-related factors.

    abstract:BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...


    pub_type: 杂志文章


    authors: Onukwugha E,Osteen P,Jayasekera J,Mullins CD,Mair CA,Hussain A

    更新日期:2014-11-01 00:00:00

  • Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas.

    abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...


    pub_type: 杂志文章


    authors: Ng EH,Pollock RE,Romsdahl MM

    更新日期:1992-03-15 00:00:00

  • Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy.

    abstract::Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...


    pub_type: 杂志文章


    authors: Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

    更新日期:1985-06-15 00:00:00

  • Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center.

    abstract:BACKGROUND:Poor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15-39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resourc...


    pub_type: 杂志文章


    authors: Collins CL,Malvar J,Hamilton AS,Deapen DM,Freyer DR

    更新日期:2015-12-15 00:00:00

  • The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase-type plasminogen activator receptor.

    abstract:BACKGROUND:Hepatocyte growth factor receptor (c-met), autocrine motility factor receptor (AMFR), and urokinase-type plasminogen activator receptor (uPAR) are known to play important roles in tumor cell migration, invasion, and metastasis. The authors studied the relation between the expression patterns of these genes a...


    pub_type: 杂志文章


    authors: Taniguchi K,Yonemura Y,Nojima N,Hirono Y,Fushida S,Fujimura T,Miwa K,Endo Y,Yamamoto H,Watanabe H

    更新日期:1998-06-01 00:00:00

  • Analyzing predictive models following definitive radiotherapy for prostate carcinoma.

    abstract:BACKGROUND:As we approach the 21st century, clinically useful predictive models for prostate carcinoma are urgently needed to stratify patients reliably for future treatment strategies. Recently, many investigators have developed models that employ prostate specific antigen (PSA)-based constructs or groupings in an att...


    pub_type: 杂志文章


    authors: Movsas B,Hanlon AL,Teshima T,Hanks GE

    更新日期:1997-09-15 00:00:00

  • A human liposarcoma cell line producing hyaluronic acid.

    abstract::A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...


    pub_type: 杂志文章


    authors: Morgan RT,Quinn LA,Moore GE,Semple TU,Woods LK

    更新日期:1980-03-15 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy and paraparesis: remission with chemotherapy. A case report.

    abstract::A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...


    pub_type: 杂志文章


    authors: Haas RJ,Helmig MS,Prechtel K

    更新日期:1978-07-01 00:00:00

  • Phase I-II trial of percutaneous intra-arterial cis-diamminedichloro platinum (II) for regionally confined malignancy.

    abstract::Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cis-diamminedichloro platinum II in a Phase I-II trial. A safe starting dose of 120 mg/m2 was established. An overall response rate of 45% was noted with significant responses observed among patients with melanoma, sarco...


    pub_type: 杂志文章


    authors: Calvo DB 3rd,Patt YZ,Wallace S,Chuang VP,Benjamin RS,Pritchard JD,Hersh EM,Bodey GP Sr,Mavligit GM

    更新日期:1980-03-15 00:00:00