Acquired Glanzmann's thrombasthenia associated with Hodgkin's lymphoma: a case report and review of the literature.

Abstract:

BACKGROUND:Acquired Glanzmann's thrombasthenia is a rare hemorrhagic diathesis resulting from impaired adhesive function of the platelet receptor GPIIb/IIIa (alpha(IIb)beta3). Typically, this disorder develops during adulthood, with patients manifesting fluctuating clinical and laboratory findings. To date, the underlying defect of most if not all cases of acquired Glanzmann's thrombasthenia results from an autoantibody or plasma protein inhibitor directed toward a demonstrably normal GPIIb/IIIa glycoprotein. METHODS:In this report, a patient with a history of treated Hodgkin's lymphoma presented with a severe hemorrhagic diathesis characterized by mild thrombocytopenia, a prolonged bleeding time, and defective platelet aggregation. RESULTS:Examination of the patient's platelet GPIIb/IIIa by Western blot analysis revealed no abnormality. Mixing studies demonstrated a non-immunoglobulin G plasma inhibitory factor, whereas flow cytometry analysis revealed elevated platelet-associated immunoglobulin (Ig) M. After an emergency colectomy for severe hemorrhage, the patient's qualitative and quantitative platelet parameters significantly improved. Pathology of the resected colonic segment demonstrated atypical lymphoid hyperplastic lesions. CONCLUSIONS:To the authors' knowledge, this is the first reported case of acquired Glanzmann's thrombasthenia associated with a putative IgM autoantibody. Furthermore, this report verifies the association of acquired thrombasthenia with lymphoproliferative disease. Although rare, awareness of this hemorrhagic diathesis as a possible sequelae of active or treated lymphoid disorders should encourage clinical vigilance of these patients.

journal_name

Cancer

journal_title

Cancer

authors

Malik U,Dutcher JP,Oleksowicz L

doi

10.1002/(sici)1097-0142(19980501)82:9<1769::aid-cn

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

1764-8

issue

9

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19980501)82:9<1764::AID-CN

journal_volume

82

pub_type

杂志文章,评审

相关文献

CANCER文献大全
  • Comparative tumor localization of whole immunoglobulin G anticarcinoembryonic antigen monoclonal antibodies IMMU-4 and IMMU-4 F(ab')2 in colorectal cancer patients.

    abstract:BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940201)73:3+<850::aid-cncr2820

    authors: Murray JL,Rosenblum MG,Zhang HZ,Podoloff DA,Kasi LP,Curley SA,Chan JC,Roh M,Hohn DC,Brewer H

    更新日期:1994-02-01 00:00:00

  • Activated CD4-positive T-lymphocytes and impaired cell-mediated immunity in patients with carcinoma of the urinary bladder with schistosomiasis.

    abstract::Patients with schistosomiasis of the urinary bladder (SB) associated with carcinoma of the bladder (SCB) or carcinoma of the prostate (SCP) have a variety of immunologic abnormalities, including the presence of HLA-DR+ and interleukin-2 receptor-positive (IL-2R+) T-lymphocytes in circulating blood. This study demonstr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900215)65:4<931::aid-cncr28206

    authors: Raziuddin S,Shetty S,Ibrahim A,Patil K

    更新日期:1990-02-15 00:00:00

  • Cutaneous basal cell carcinomas: distinct host factors are associated with the development of tumors on the trunk and on the head and neck.

    abstract:BACKGROUND:Patients with basal cell carcinoma (BCC) demonstrate marked variation in clinical phenotype, suggesting the presence of distinct subgroups. Patients with truncal lesions comprise an interesting subgroup, because, although the pathogenesis of these tumors is unclear, there is evidence to suggest that their de...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010715)92:2<354::aid-cncr1330>

    authors: Ramachandran S,Fryer AA,Smith A,Lear J,Bowers B,Jones PW,Strange RC

    更新日期:2001-07-15 00:00:00

  • Evaluation of the quality of radiotherapy randomized trials for painful bone metastases.

    abstract:BACKGROUND:The quality of randomized radiotherapy studies investigating the palliation of painful bone metastases has been questioned, with some authors recognizing the potential impact of bias on result interpretation. However, there has been no published comprehensive evaluation of quality assessment. The goals of th...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.20993

    authors: Shakespeare TP,Thiagarajan A,Gebski V

    更新日期:2005-05-01 00:00:00

  • Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy.

    abstract::Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia. Thymic carcinomas may metastasize outside of the thorax and are associated with a very poor prognosis. Complete responses of thymic carcinoma to chemotherapy a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/1097-0142(19901115)66:10<2092::aid-cncr282

    authors: Carlson RW,Dorfman RF,Sikic BI

    更新日期:1990-11-15 00:00:00

  • Selecting initial therapy for prostate cancer. Radiation therapy perspective.

    abstract::External-beam irradiation of prostatic cancer was introduced at Stanford in 1956. The program has sought to determine the following: whether prostatic carcinoma can be cured by external beam radiation therapy, with what frequency this can be accomplished, which patients are best suited for irradiation, and what techni...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870801)60:3+<521::aid-cncr2820

    authors: Bagshaw MA,Ray GR,Cox RS

    更新日期:1987-08-01 00:00:00

  • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.

    abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820

    authors: Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

    更新日期:1982-03-15 00:00:00

  • Combining radioimmunotherapy and chemotherapy for treatment of medullary thyroid carcinoma: effectiveness of dacarbazine.

    abstract:BACKGROUND:To enhance the efficacy of chemotherapy for medullary thyroid carcinoma (MTC), we evaluated the effect of combining radioimmunotherapy (RAIT) with 90Y-anticarcinoembryonic antigen (CEA) monoclonal antibody MN-14 and chemotherapy in nude mice bearing human MTC xenografts. A preliminary study evaluated doxorub...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10157

    authors: Stein R,Chen S,Reed L,Richel H,Goldenberg DM

    更新日期:2002-01-01 00:00:00

  • Highlights of the evidence of benefit for women aged 40-49 years from the 14-year follow-up of the Breast Cancer Detection Demonstration Project.

    abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.2820741314

    authors: Smart CR

    更新日期:1994-07-01 00:00:00

  • Randomized trial comparing cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) with rotational CMF, epirubicin and vincristine as primary chemotherapy in operable breast carcinoma.

    abstract:BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.10678

    authors: Cocconi G,Di Blasio B,Boni C,Bisagni G,Ceci G,Rondini E,Bella M,Leonardi F,Savoldi L,Camisa R,Bruzzi P

    更新日期:2002-07-15 00:00:00

  • Morphologic and immunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies.

    abstract:BACKGROUND:Estramustine phosphate (EMP) and flutamide (FL) were used as reversible preoperative hormonal drugs in the surgical treatment of patients with localized prostate cancer. METHODS:The authors descriptive and quantitatively examined the morphologic and immunohistochemical changes in 40 of 200 step-sectioned ra...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941215)74:12<3164::aid-cncr282

    authors: Van de Voorde WM,Elgamal AA,Van Poppel HP,Verbeken EK,Baert LV,Lauweryns JM

    更新日期:1994-12-15 00:00:00

  • The immunochemical complexity of CEA: a golden dream or molecular nightmare?

    abstract::Carcinoembryonic antigen is only a tumor assoicated antigen and is less clinically useful than the original report suggested. However, the CEA assays in clinical use utilize reagents operationally defined by old criteria. There is now abundant evidence that "CEA" consists of a heterogenous family of related glycoprote...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3+<1585::aid-cncr28204

    authors: Alpert E

    更新日期:1978-09-01 00:00:00

  • Chemical carcinogenesis.

    abstract::The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macrom...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197707)40:1+<430::aid-cncr282040

    authors: Heidelberger C

    更新日期:1977-07-01 00:00:00

  • Hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and mitomycin-C (+/- granulocyte-colony stimulating factor) in the treatment of patients with locally advanced head and neck carcinoma.

    abstract:BACKGROUND:The authors had previously reported preliminary results of a treatment regimen of concurrent hyperfractionated radiation therapy and chemotherapy in patients with locally advanced head and neck carcinoma that demonstrated both feasibility and high local control. In an attempt to reduce acute mucosal and hema...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19970715)80:2<266::aid-cnc

    authors: Abitbol AA,Sridhar KS,Lewin AA,Schwade JG,Raub W Jr,Wolfson A,Gonzalez-Angulo C,Adessa A,Goodwin WJ,Markoe AM

    更新日期:1997-07-15 00:00:00

  • Barriers to health care contribute to delays in follow-up among women with abnormal cancer screening: Data from the Patient Navigation Research Program.

    abstract:BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29607

    authors: Ramachandran A,Snyder FR,Katz ML,Darnell JS,Dudley DJ,Patierno SR,Sanders MR,Valverde PA,Simon MA,Warren-Mears V,Battaglia TA,Patient Navigation Research Program Investigators.

    更新日期:2015-11-15 00:00:00

  • Leukemic iritis with hypopyon.

    abstract::A patient with acute lymphoblastic leukemia who had received CNS sanctuary treatment with cranial X-irradiation and intrathecal methotrexate displayed his first sign of relapse as iritis with malignant hypopyon. Treatment included topical and subconjunctival corticosteroids and local X-irradiation. Leukemic infiltrati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197910)44:4<1511::aid-cncr282044

    authors: Gruenewald RL,Perry MC,Henry PH

    更新日期:1979-10-01 00:00:00

  • Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer: findings from the bolus, infusional, or capecitabine with camptostar-celecoxib study.

    abstract:BACKGROUND:Irinotecan-based chemotherapy regimens are 1 option for treatment of metastatic colorectal cancer (mCRC). The authors report the safety and efficacy of such regimens in elderly patients using a large phase III trial (bolus, infusional, or capecitabine with camptostar-celecoxib [BICC-C]) cohort. METHODS:In p...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.24305

    authors: Jackson NA,Barrueco J,Soufi-Mahjoubi R,Marshall J,Mitchell E,Zhang X,Meyerhardt J

    更新日期:2009-06-15 00:00:00

  • Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence.

    abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN

    authors: Kato M,Ito Y,Kobayashi S,Isono K

    更新日期:1996-04-15 00:00:00

  • Prognostic impact of morphometric nuclear grade of endometrial carcinoma.

    abstract:BACKGROUND:The identification of high risk patients with endometrial carcinoma is considered essential for individualized therapy to improve prognosis and avoid overtreatment. The goal of the current study was to investigate the prognostic value of nuclear morphometry, particularly for patients with localized endometri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Salvesen HB,Iversen OE,Akslen LA

    更新日期:1998-09-01 00:00:00

  • A renal cell carcinoma neoplastic antigen detectable by immunohistochemistry is defined by a murine monoclonal antibody.

    abstract::BALB/c mice were hyperimmunized with ACHN (ATCC CRL 1611, American Type Culture Collection, Rockville, Maryland), a stable in vitro cell line derived from a malignant pleural effusion in a 22-year-old man with renal cell carcinoma. The hyperimmune spleen cells were fused with NS-1 murine myeloma cells using polyethyle...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2031::aid-cncr282

    authors: Kochevar J

    更新日期:1987-06-15 00:00:00

  • Treatment of fludarabine-refractory chronic lymphocytic leukemia.

    abstract::The development of resistance to purine analogs defines a poor-risk subset of patients with chronic lymphocytic leukemia (CLL). Although in recent years chemoimmunotherapeutic combinations such as fludarabine, cyclophosphamide, and rituximab have induced response rates of 95% in previously untreated patients and incre...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.24329

    authors: Tsimberidou AM,Keating MJ

    更新日期:2009-07-01 00:00:00

  • Risk of mortality in patients with cancer who experience febrile neutropenia.

    abstract:BACKGROUND:Febrile neutropenia (FN) is a serious and potentially life-threatening condition that may develop in patients with cancer who receive myelosuppressive chemotherapy. The risk of mortality from FN is not well characterized in current clinical practice. METHODS:Patients with cancer who were receiving chemother...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25332

    authors: Lyman GH,Michels SL,Reynolds MW,Barron R,Tomic KS,Yu J

    更新日期:2010-12-01 00:00:00

  • Uterine papillary serous carcinoma after radiation therapy for carcinoma of the cervix.

    abstract::This article describes the clinicopathologic features of six cases of uterine papillary serous carcinoma (UPSC), which developed several years after radiation therapy (RT) for cervical carcinoma. The possible etiologic role of radiation is discussed, and the literature on endometrial carcinomas developing after RT is ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920115)69:2<496::aid-cncr28206

    authors: Parkash V,Carcangiu ML

    更新日期:1992-01-15 00:00:00

  • Histologic subtypes as determinants of outcome in esophageal carcinoma patients with pathologic complete response after preoperative chemoradiotherapy.

    abstract:BACKGROUND:The current study tested the hypothesis that the clinical outcome of patients with localized esophageal carcinoma after preoperative chemoradiotherapy (CTRT) depends on histology. METHODS:The authors stratified patients by adenocarcinoma (ACA) or squamous cell carcinoma (SCC) and compared the overall surviv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21601

    authors: Rohatgi PR,Swisher SG,Correa AM,Wu TT,Liao Z,Komaki R,Walsh GL,Vaporciyan AA,Rice DC,Bresalier RS,Roth JA,Ajani JA

    更新日期:2006-02-01 00:00:00

  • Real-time identification of liver cancers by using indocyanine green fluorescent imaging.

    abstract:BACKGROUND:We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compresse...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24291

    authors: Ishizawa T,Fukushima N,Shibahara J,Masuda K,Tamura S,Aoki T,Hasegawa K,Beck Y,Fukayama M,Kokudo N

    更新日期:2009-06-01 00:00:00

  • Low cancer incidence and mortality in Utah.

    abstract::Utah cancer mortality for the years 1950-1969 and morbidity for the years 1966-1970 are reported. Utah had 18% fewer cases of cancer than expected based on the Third National Cancer Survey, and 24% fewer cancer deaths than expected based on national mortality data. Cancer sites associated with cigarette smoking and al...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197706)39:6<2608::aid-cncr282039

    authors: Lyon JL,Gardner JW,Klauber MR,Smart CR

    更新日期:1977-06-01 00:00:00

  • Guideline-concordant cancer care and survival among American Indian/Alaskan Native patients.

    abstract:BACKGROUND:American Indians/Alaskan Natives (AI/ANs) have the worst 5-year cancer survival of all racial/ethnic groups in the United States. Causes for this disparity are unknown. The authors of this report examined the receipt of cancer treatment among AI/AN patients compared with white patients. METHODS:This was a r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28683

    authors: Javid SH,Varghese TK,Morris AM,Porter MP,He H,Buchwald D,Flum DR,Collaborative to Improve Native Cancer Outcomes (CINCO).

    更新日期:2014-07-15 00:00:00

  • Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer (Dukes' class C): prolongation of disease-free interval and survival.

    abstract::The poor postsurgical prognosis in patients with colorectal cancer of the Dukes' C classification has prompted a clinical trial of adjuvant immunotherapy versus chemoimmunotherapy intended to prolong either the disease-free interval or the overall survival or both. One hundred and twenty-one patients have been entered...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197711)40:5+<2726::aid-cncr28204

    authors: Mavligit GM,Gutterman JU,Malahy MA,Burgess MA,McBride CM,Jubert A,Hersh EM

    更新日期:1977-11-01 00:00:00

  • Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma.

    abstract::A familial cancer aggregation comprising sarcomas, brain tumors, leukemias, and carcinomas of breast, larynx, lung, adrenal, cortex, and other sites has been studied from a pathologic--genetic standpoint. Based upon sibships segregating for cancer, the genetic segregation parameter is estimated to be 45.6 +/- 11% whi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197805)41:5<2055::aid-cncr282041

    authors: Lynch HT,Mulcahy GM,Harris RE,Guirgis HA,Lynch JF

    更新日期:1978-05-01 00:00:00

  • Trends in multiple myeloma presentation, management, cost of care, and outcomes in the Medicare population: A comprehensive look at racial disparities.

    abstract:BACKGROUND:Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODS:Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31237

    authors: Ailawadhi S,Frank RD,Sharma M,Menghani R,Temkit M,Paulus S,Khera N,Hashmi S,Advani P,Swaika A,Paulus A,Aslam N,Sher T,Roy V,Colon-Otero G,Chanan-Khan A

    更新日期:2018-04-15 00:00:00