Combining radioimmunotherapy and chemotherapy for treatment of medullary thyroid carcinoma: effectiveness of dacarbazine.

abstract：:The efficacy of mitoxantrone in combination with vinblastine was assessed in 156 patients with metastatic breast cancer who had been treated previously with one or multiple chemotherapeutic regimens. Mitoxantrone was given by random assignment, either as a 10 mg/m2 single intravenous dose or in five consecutive daily ...

journal_title：Cancer

authors： Fraschini G,Yap HY,Mann G,Buzdar AU,Blumenschein GR,Hortobagyi GN

更新日期：1987-10-15 00:00:00

abstract：BACKGROUND:Prognosis of patients with adenocarcinoma of the pancreatic body and tail is extremely poor. Anatomically, this part of the pancreas is thin, and cancerous invasion to the retropancreatic structures occurs easily. The majority of patients have residual tumor in the retroperitoneal tissues after conventional ...

journal_title：Cancer

authors： Ozaki H,Kinoshita T,Kosuge T,Yamamoto J,Shimada K,Inoue K,Koyama Y,Mukai K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Testing for oral high-risk human papillomavirus (HPV) DNA may be useful for identifying individuals at increased risk for HPV-driven oropharyngeal cancer (OPC). However, positivity for HPV DNA provides no information on the transforming potential of the infection. In contrast, the detection of high-risk HPV ...

journal_title：Cancer

authors： Rollo F,Pichi B,Benevolo M,Giuliani M,Latini A,Lorenzon L,Colafigli M,Frasca M,Pellini R,Cristaudo A,Donà MG

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Ependymomas account for 2% of all intracranial tumors in adults. Supratentorial ependymomas are less common than their infratentorial counterparts. To the authors' knowledge to date, the predictive values of surgery, histology, and patient-related prognostic factors for these tumors remain unresolved. The au...

journal_title：Cancer

authors： Metellus P,Figarella-Branger D,Guyotat J,Barrie M,Giorgi R,Jouvet A,Chinot O,Club de Neuro-Oncologie de la Société Française de Neurochirurgie and the Association des Neuro-Oncologues d'Expression Française.

更新日期：2008-07-01 00:00:00

abstract：:In a study conducted by the Eastern Cooperative Oncology Group, 51 evaluable women with advanced ovarian carcinoma were randomized to either abdominal radiation therapy alone, chlorambucil alone, or to a combination of radiation therapy and chlorambucil by members of the Eastern Cooperative Oncology Group. Provision w...

journal_title：Cancer

authors： Miller SP,Brenner S,Horton J,Stolbach L,Shnider BI,Pocock S

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:In the United States, detection of squamous carcinoma in situ (CIS) by screening has led to reduced rates for invasive squamous carcinoma and lower mortality. Adenocarcinoma in situ (AIS) rates also have increased, but invasive cervical adenocarcinoma rates have not declined similarly. To make inferences abo...

journal_title：Cancer

authors： Sherman ME,Wang SS,Carreon J,Devesa SS

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:The purpose of the current study was to test the hypothesis that a lower clinical TNM stage is associated with a higher rate of pathologic complete response (pathCR) in patients with esophageal carcinoma receiving preoperative chemoradiotherapy and to determine whether outcome after pathCR is related to clin...

journal_title：Cancer

authors： Rohatgi P,Swisher SG,Correa AM,Wu TT,Liao Z,Komaki R,Walsh GL,Vaporciyan AA,Rice DC,Roth JA,Ajani JA

更新日期：2005-12-01 00:00:00

abstract：:Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demo...

journal_title：Cancer

authors： Pearson JP,Pretlow TP,Bradley EL Jr,McGinnis MC,Pretlow TG

更新日期：1989-08-15 00:00:00

abstract：BACKGROUND:Cervical carcinoma remains a significant health risk for the older woman. In the current study the yield of screening of mature women in an established, opportunistic screening program was examined. Strategies for improving screening in this age group were identified through examination of recent Pap test hi...

journal_title：Cancer

authors： Colgan TJ,Clarke A,Hakh N,Seidenfeld A

更新日期：2002-08-25 00:00:00

abstract：:The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-n...

journal_title：Cancer

authors： Esteban F,Ruiz-Cabello F,Concha A,Perez Ayala M,Delgado M,Garrido F

更新日期：1990-10-01 00:00:00

abstract：:The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

journal_title：Cancer

authors： Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

更新日期：1986-07-15 00:00:00

abstract：BACKGROUND:Several studies have shown that lysophosphatidic acid (LPA), a phospholipidic chemical mediator, is relevant to the pathogenesis of ovarian carcinoma. Higher plasma levels of LPA have been reported in patients with ovarian carcinoma than in healthy patients, and LPA is known to activate ovarian carcinoma cel...

journal_title：Cancer

authors： Tokumura A,Tominaga K,Yasuda K,Kanzaki H,Kogure K,Fukuzawa K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The ability to divide subsets of patients with glial neoplasms into prognostic groups currently is limited because only a few clinical and pathologic variables are available. The goal of this investigation was to identify biologic factors of potential prognostic value in patients with cerebral gliomas. METH...

journal_title：Cancer

authors： Ganju V,Jenkins RB,O'Fallon JR,Scheithauer BW,Ransom DT,Katzmann JA,Kimmel DW

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The polyamine system is a promising target for anticancer therapy. Ideally, an antineoplastic compound affecting this system should inhibit both ornithine decarboxylase and the polyamine transporter, and toxicity should be mild. Agmatine, decarboxylated L-arginine, appears to be such a compound. METHODS:Ade...

journal_title：Cancer

authors： Molderings GJ,Kribben B,Heinen A,Schröder D,Brüss M,Göthert M

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:Activation of telomerase, a ribonucleoprotein enzyme complex that synthesizes telomere repeats, is associated with acquisition of unlimited cellular proliferation and is commonly detected in human cancer. Measurement of telomerase activity (TA) may provide important information as a diagnostic marker or a pr...

journal_title：Cancer

authors： Shoji Y,Yoshinaga K,Inoue A,Iwasaki A,Sugihara K

更新日期：2000-03-15 00:00:00

abstract：:Multiple independent tumors were identified in specimens from 117 of 234 prostatectomies for clinical adenocarcinoma; there were 266 incidental cancers in these 117 prostates. The clinically detected carcinoma was the largest (or only) tumor in all 202 Stage B cases. However, among 32 Stage A cases (detection by trans...

journal_title：Cancer

authors： Villers A,McNeal JE,Freiha FS,Stamey TA

更新日期：1992-11-01 00:00:00

abstract：:This study examines the interrelationships of depth of penetration, tumor size, and the number of positive nodes in Dukes C colorectal cancer. The results indicated that depth of tumor penetration was related to both tumor size and the number of positive regional lymph nodes. Tumors with positive nodes which failed to...

journal_title：Cancer

authors： Wolmark N,Fisher ER,Wieand HS,Fisher B

更新日期：1984-06-15 00:00:00

abstract：:This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...

journal_title：Cancer

authors： Wahl RL

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:The ability of screening mammography programs serving women of different socioeconomic status (SES) to diagnose early stage breast carcinoma in a comparably effective fashion has been questioned. METHODS:Results of screening 50,653 women of lower SES were compared with those of screening 45,923 more socioec...

journal_title：Cancer

authors： Dershaw DD,Loring L,True SJ,Momrow DC,Liberman L,Morris EA

更新日期：1998-05-01 00:00:00

abstract：:Six cases of desmoplastic melanoma were studied by light and electron microscopy. The tumors fulfilled one or more of the following criteria: (1) having the presence of atypical intraepidermal melanocytic proliferation bordering the primary lesions; (2) an antecedent history of melanoma at the site of recurrence; (3) ...

journal_title：Cancer

authors： DiMaio SM,Mackay B,Smith JL Jr,Dickersin GR

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dose of everolimus with gefitinib in pati...

journal_title：Cancer

authors： Milton DT,Riely GJ,Azzoli CG,Gomez JE,Heelan RT,Kris MG,Krug LM,Pao W,Pizzo B,Rizvi NA,Miller VA

更新日期：2007-08-01 00:00:00

abstract：:The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight ...

journal_title：Cancer

authors： Loy TS,Kyle J,Bickel JT

更新日期：1989-04-15 00:00:00

abstract：BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

journal_title：Cancer

authors： Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

更新日期：1993-01-01 00:00:00

abstract：:With nearly 80% of childhood cancer patients achieving cure, there are more adult survivors living now than at any other time in history. Because they are at risk for developing complications of treatment years later, it is recommended that survivors undergo systematic, regular monitoring into young adulthood and beyo...

journal_title：Cancer

authors： Freyer DR,Kibrick-Lazear R

更新日期：2006-10-01 00:00:00

abstract：:Data are presented on mortality from neoplasms as determined from death certificates in a cohort of 8393 college men, according to athletic status in college. Major athletes (lettermen) died significantly more often from neoplasms than nonathletes. Mean age at death from neoplasms (underlying cause) was significantly ...

journal_title：Cancer

authors： Polednak AP

更新日期：1976-07-01 00:00:00

abstract：:Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a...

journal_title：Cancer

authors： Mottolese M,Venturo I,Rinaldi M,Campioni N,Aluffi A,Curcio CG,Donnorso RP,Natali PG

更新日期：1989-12-15 00:00:00

abstract：:Cases of childhood cancer (less than 15 years of age at diagnosis), diagnosed between 1960 and 1984, were obtained from the Hawaii Tumor Registry, a population-based Surveillance, Epidemiology, and End Results (SEER) participant covering the entire State of Hawaii. During the 25 years of data collection, cancer was di...

journal_title：Cancer

authors： Goodman MT,Yoshizawa CN,Kolonel LN

更新日期：1989-10-15 00:00:00

abstract：BACKGROUND:Hormone replacement therapy (HRT) has proven and presumable benefits for women desiring postmenopausal health preservation. Among HRT-associated risks, the fear of breast carcinoma intimidates women and physicians contemplating hormonal treatment and limits long-term compliance. Identifying effective alterna...

journal_title：Cancer

authors： Diamanti-Kandarakis E,Sykiotis GP,Papavassiliou AG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The response to antifungal therapy alone often is suboptimal in patients with cancer who have therapy-refractory neutropenia, and even donor-derived granulocyte transfusions (GTX) are not always successful. The authors evaluated the safety and efficacy of immune enhancement using recombinant interferon gamma...

journal_title：Cancer

authors： Safdar A,Rodriguez GH,Lichtiger B,Dickey BF,Kontoyiannis DP,Freireich EJ,Shpall EJ,Raad II,Kantarjian HM,Champlin RE

更新日期：2006-06-15 00:00:00

abstract：:Neuroblastoma is the most common neoplasm in children less than 1 year of age and has one of the earliest incidence peaks of all childhood cancers. Using birth registration data, a matched case-control study was undertaken to investigate potential prenatal and perinatal risk factors. Ninety-seven neuroblastoma patient...

journal_title：Cancer

authors： Neglia JP,Smithson WA,Gunderson P,King FL,Singher LJ,Robison LL

更新日期：1988-06-01 00:00:00