Abstract:
:Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a selected panel of monoclonal antibodies (MoAb) to tumor-associated antigens (TAA) can improve the diagnostic potential of FNA, we have immunocytochemically analyzed 122 pulmonary CT-FNA. Whereas conventional cytology was capable of recognizing only the neoplastic nature of the lesions, the immunocytochemical diagnosis could identify the primary or metastatic nature of the pulmonary masses in 92.5% of the cases. The immunocytochemical findings were confirmed by clinical-histopathologic data. The current results demonstrate that the use of immunocytochemical methods can significantly improve the diagnostic accuracy of conventional cytology of lung masses.
journal_name
Cancerjournal_title
Cancerauthors
Mottolese M,Venturo I,Rinaldi M,Campioni N,Aluffi A,Curcio CG,Donnorso RP,Natali PGdoi
10.1002/1097-0142(19891215)64:12<2493::aid-cncr282subject
Has Abstractpub_date
1989-12-15 00:00:00pages
2493-500issue
12eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
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