Combinations of monoclonal antibodies can distinguish primary lung tumors from metastatic lung tumors sampled by fine needle aspiration biopsy.

Abstract:

:Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a selected panel of monoclonal antibodies (MoAb) to tumor-associated antigens (TAA) can improve the diagnostic potential of FNA, we have immunocytochemically analyzed 122 pulmonary CT-FNA. Whereas conventional cytology was capable of recognizing only the neoplastic nature of the lesions, the immunocytochemical diagnosis could identify the primary or metastatic nature of the pulmonary masses in 92.5% of the cases. The immunocytochemical findings were confirmed by clinical-histopathologic data. The current results demonstrate that the use of immunocytochemical methods can significantly improve the diagnostic accuracy of conventional cytology of lung masses.

journal_name

Cancer

journal_title

Cancer

authors

Mottolese M,Venturo I,Rinaldi M,Campioni N,Aluffi A,Curcio CG,Donnorso RP,Natali PG

doi

10.1002/1097-0142(19891215)64:12<2493::aid-cncr282

subject

Has Abstract

pub_date

1989-12-15 00:00:00

pages

2493-500

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

64

pub_type

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