Chronic neurologic disturbance in childhood leukemia.

Abstract:

:Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed in 12 patients, all of whom had intermittent limping and mild incoordination, between the 10th and 18th month of maintenance therapy. Five of the 12 sustained seizures and four of these had subsequent abnormalities in motor, perceptual, behavioral or language development. Three school-aged children have learning disability and perceptual-motor defects. Studies of CSF folate and MTX content are presented but not helpful in delineating the etiology of these neurologic symptoms.

journal_name

Cancer

journal_title

Cancer

authors

McIntosh S,Klatskin EH,O'Brien RT,Aspnes GT,Kammerer BL,Snead C,Kalavsky SM,Pearson HA

doi

10.1002/1097-0142(197602)37:2<853::aid-cncr2820370

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

853-7

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

37

pub_type

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