Abstract:
:Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HLA-DR loci. These results were compared. Multivariate statistical analysis using stepwise logistic regression revealed significant associations between the incidence of SqCC and HLA-B14, HLA-DR3, and HLA-DR4 as well as smoking and the sex-smoking interaction. The authors concluded that certain host factors, including genetic constitution, and behavioral characteristics (i.e., smoking) as well as tumor biology, can influence the development of SqCC. The mechanism(s) of these associations may involve as yet undefined relationships between HLA region genes and the immune response.
journal_name
Cancerjournal_title
Cancerauthors
Houck JR,Romano PJ,Bartholomew M,Smith PJ,Kloszewski F,Vesell ESdoi
10.1002/1097-0142(19920501)69:9<2327::aid-cncr2820subject
Has Abstractpub_date
1992-05-01 00:00:00pages
2327-32issue
9eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
杂志文章相关文献
CANCER文献大全abstract::Six patients with metastatic mixed germ-cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821015)50:8<1629::aid-cncr2820
更新日期:1982-10-15 00:00:00
abstract::A case of meningeal melanocytoma of the left Meckel's cave associated with ipsilateral Ota's nevus in a 43-year-old woman, was studied by light and electron microscopy. The cells of the tumor were characterized by the presence of dendritic cytoplasmic processes, melanosomes and premelanosomes; hence, they were deemed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12<2304::aid-cncr282
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:Metastatic renal cell cancer is associated with poor long-term survival and has no cure. Traditional clinical endpoints are best supplemented by patient-reported outcomes designed to assess symptoms and function. Normative data was obtained on the National Comprehensive Cancer Network-Functional Assessment o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27688
更新日期:2013-01-15 00:00:00
abstract::CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<121::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract::Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:2+<2795::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:: The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy. METHODS:: The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24891
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20353
更新日期:2004-07-15 00:00:00
abstract::Whether malignant cells can be detected in the bowel movements induced by oral gut lavage solution administration was studied in patients with known colonic adenocarcinomas. The induced bowel movements were collected in 27 patients, nine of whom had cancer proven by anatomic pathologic examination. The cells present w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910701)68:1<106::aid-cncr28206
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25961
更新日期:2011-08-15 00:00:00
abstract::The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macrom...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197707)40:1+<430::aid-cncr282040
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:The purpose of the current analysis was to evaluate the impact of local recurrence (LR) on the development of distant metastases (DM), overall survival (OS), and cause specific survival (CSS) in patients with early-stage breast carcinoma who underwent conservative surgery (CS) and received postoperative radi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11143
更新日期:2003-02-15 00:00:00
abstract::We synthesized doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH)-loaded human albumin microspheres (containing approximately 1% doxorubicin w/w) between 15 and 20 micron in diameter. Intrarenal arterial administration of 99mTC-labeled microspheres demonstrated a high renal entrapment ratio (97% of recovered r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880901)62:5<878::aid-cncr28206
更新日期:1988-09-01 00:00:00
abstract::The relationship between cytogenetic findings and prognosis in 51 pediatric patients with neuroblastoma is described. Patients were classified into the following four groups based on karyotypic findings: (1) near diploidy, 42 to 47 chromosomes (n = 11); (2) hyperdiploidy, 50 to 56 chromosomes (n = 4); (3) near triploi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890101)63:1<126::aid-cncr28206
更新日期:1989-01-01 00:00:00
abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Desmoplastic melanoma is an uncommon variant of cutaneous melanoma that mimics soft tissue sarcoma both clinically and morphologically. An activating point mutation of the BRAF oncogene has been identified in a high proportion of conventional cutaneous melanomas, but its frequency in the desmoplastic subtype...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20861
更新日期:2005-02-15 00:00:00
abstract::An unusual tumor of the cystic duct in a 28-year-old woman is described. The patient presented with a painful distended gallbladder due to a small tumor occluding the cystic duct. Microscopically the tumor cells showed a nesting pattern suggestive of endocrine differentiation, but contained numerous lipid vacuoles and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840201)53:3<498::aid-cncr28205
更新日期:1984-02-01 00:00:00
abstract::The hepatic histopathology was studied in 125 patients with Hodgkin's disease to determine whether there are any features other than Reed-Sternberg (RS) cells that might aid in the diagnosis of hepatic involvement by the neoplastic process. Liver biopsy specimens from 41 patients with Hodgkin's disease in the liver we...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891115)64:10<2121::aid-cncr282
更新日期:1989-11-15 00:00:00
abstract::To investigate the utility of thallium 201 (Tl-201) thyroid scintigraphy for the detection of thyroid malignancies, early and delayed Tl-201 scintigraphy was done in 70 consecutive patients with a clinically solitary cold (Iodine 123 [I-123]) nodule. Early Tl-201 scintigraphy had a sensitivity of 100% and a specificit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871201)60:11<2621::aid-cncr282
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Patients who have aggressive, refractory or recurrent non-Hodgkin lymphomas (NHLs) that are refractory to first-line anthracycline-containing regimens (ACRs) have a dismal outcome. Achieving complete remission (CR) is essential for a favorable outcome. To improve the CR rate in these patients, the authors de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21150
更新日期:2005-08-01 00:00:00
abstract::The prolonged administration of bisphosphonates can reduce the frequency of morbid skeletal events in patients with metastatic breast carcinoma or multiple myeloma. The development of more potent bisphosphonates will simplify current therapeutic schemes and could improve the therapeutic effectiveness of bisphosphonate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1699::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:The purpose of the current study was to test the hypothesis that a lower clinical TNM stage is associated with a higher rate of pathologic complete response (pathCR) in patients with esophageal carcinoma receiving preoperative chemoradiotherapy and to determine whether outcome after pathCR is related to clin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21439
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:With the move away from classical radical mastectomy to ever more skin-sparing procedures, there has been an ongoing discussion about how much skin and subcutaneous tissue should be resected to perform an adequate mastectomy while leaving viable skin flaps. One of the common recommendations is to dissect jus...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10429
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25099
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Radioimmunotherapy with radiolabeled monoclonal antibodies to CD20 produces a high response rate in patients with recurring non-Hodgkin lymphoma (NHL), but the durability of those remissions is not well defined. METHODS:Data on patients with recurring NHL treated with yttrium Y 90 ibritumomab tiuxetan in 4 ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.22617
更新日期:2007-05-01 00:00:00
abstract::Although the conference could not provide a definitive etiologic explanation for the observed increase in incidence of human brain tumors, particularly among the elderly, nevertheless, this interdisciplinary gathering of prominent scientists and clinicians proved invaluable in identifying new avenues of research. Clea...
journal_title:Cancer
pub_type:
doi:10.1002/1097-0142(19950815)76:4<709::aid-cncr28207
更新日期:1995-08-15 00:00:00
abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040
更新日期:1984-08-15 00:00:00
abstract::Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800801)46:3<452::aid-cncr28204
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Many studies have tried to identify prognostic factors to guide the selection of patients at high risk for metastases in penile carcinoma. The authors evaluated human papillomavirus (HPV) status with respect to clinical features, incidence of metastases, and prognosis of penile carcinoma. METHODS:Human papi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-15 00:00:00
abstract:BACKGROUND:Arthralgia is common in postmenopausal breast cancer survivors (BCS) who are receiving aromatase inhibitors (AIs). The objective of this study was to evaluate the perceived onset, characteristics, and risk factors for AI-related arthralgia (AIA). METHODS:In a cross-sectional survey of postmenopausal BCS who...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24419
更新日期:2009-08-15 00:00:00
abstract::The use of preoperative computed tomographic (CT) scans of the chest in carcinoma of the esophagus to associate preoperative staging with postoperative survival is controversial. Thirty-two patients who underwent esophagectomy and reconstruction were examined with respect to a variety of variables available on preoper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1287::aid-cncr2820
更新日期:1988-10-01 00:00:00