Abstract:
:We synthesized doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH)-loaded human albumin microspheres (containing approximately 1% doxorubicin w/w) between 15 and 20 micron in diameter. Intrarenal arterial administration of 99mTC-labeled microspheres demonstrated a high renal entrapment ratio (97% of recovered radioactivity). The pharmacokinetics and metabolism of doxorubicin are different when it is administered in microspherical form. Peak plasma levels are lower (16 ng/ml versus 135 ng/ml) compared with treatment by a doxorubicin solution. Histologic studies showed that the microspheres were trapped within capillaries and small arterioles in the renal vascular arcade. It is apparent that chemoembolization with doxorubicin-loaded microspheres significantly reduces systemic exposure to the antineoplastic agent, and maintains intrarenal drug levels.
journal_name
Cancerjournal_title
Cancerauthors
Kerr DJ,Willmott N,McKillop JH,Cummings J,Lewi HJ,McArdle CSdoi
10.1002/1097-0142(19880901)62:5<878::aid-cncr28206subject
Has Abstractpub_date
1988-09-01 00:00:00pages
878-83issue
5eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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