Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

Abstract:

:The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriate approach when the disease recurs very early after the end of chemotherapy, whereas platinum-based chemotherapy is usually adopted when the platinum-free interval exceeds 12 months. However, the therapeutic management of patients with intermediate sensitivity (ie, when the relapse occurs between 6 and 12 months) remains debatable. Preclinical and clinical data suggest that the extension of platinum-free interval (using a nonplatinum-based regimen) might restore platinum sensitivity, thus allowing survival improvement. The objective of this review was to critically analyze preclinical and clinical evidences supporting this hypothesis. Cancer 2017;123:3450-9. © 2017 American Cancer Society.

journal_name

Cancer

journal_title

Cancer

authors

Tomao F,D'Incalci M,Biagioli E,Peccatori FA,Colombo N

doi

10.1002/cncr.30830

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

3450-3459

issue

18

eissn

0008-543X

issn

1097-0142

journal_volume

123

pub_type

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