Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer.

abstract：BACKGROUND:The runt-related transcription factor RUNX3 plays essential roles in various types of tumors, including gastric cancer. Epigenetic changes in the methylation of the RUNX3 proximal promoter, but not common genetic changes in RUNX3, have been associated with both changes in the gene expression and development ...

journal_title：Cancer

authors： Lim B,Ju H,Kim M,Kang C

更新日期：2011-11-15 00:00:00

abstract：:Treatment of 91 consecutive patients having metastatic, Stage IV melanoma who had not received any previous chemotherapy was begun between January 1977 and April 1978. The therapy included bleomycin (B) at 7.5 units subcutaneously in the first course and 15 units in subsequent courses on days 1 and 4; vincristine or O...

journal_title：Cancer

authors： Seigler HF,Lucas VS Jr,Pickett NJ,Huang AT

更新日期：1980-12-01 00:00:00

abstract：:Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...

journal_title：Cancer

authors： Sheinfeld Gorin S,Gauthier J,Hay J,Miles A,Wardle J

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires...

journal_title：Cancer

authors： Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NF

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma. METHODS:Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.2 to 23.8 years (median, 3.3 yrs). All living...

journal_title：Cancer

authors： Mendenhall WM,Morris CG,Amdur RJ,Werning JW,Villaret DB

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:In Japan, where liver transplantation has not been used to treat patients with hepatocellular carcinoma (HCC), percutaneous ethanol injection (PEI) has been employed for those with small HCCs that are not amenable to surgical resection. In the current study, the authors evaluated PEI as a treatment for HCC p...

journal_title：Cancer

authors： Hasegawa S,Yamasaki N,Hiwaki T,Sako K,Komorizono Y,Baba Y,Imamura Y,Kubozono O,Yoshida A,Arima T

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) play a crucial role in carcinogenesis; however, it largely remains unclear whether miRNAs in gastric juice, which is specific for gastric tissues, can be used as biomarkers for gastric cancer. The objective of the current study was to investigate the feasibility of using gastric juice miRN...

journal_title：Cancer

authors： Cui L,Zhang X,Ye G,Zheng T,Song H,Deng H,Xiao B,Xia T,Yu X,Le Y,Guo J

更新日期：2013-05-01 00:00:00

abstract：:Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...

journal_title：Cancer

authors： Abe S,Ogura S,Kunikane H,Suko N,Watanabe N,Nakajima I,Kawakami Y,Inoue K

更新日期：1991-01-15 00:00:00

abstract：BACKGROUND:Cisplatin (CDDP) administration concomitant with radiotherapy (RT) for the treatment of locally advanced cervical cancer has evolved from an inpatient 5-day every 21-day regimen to a weekly outpatient regimen. This study was designed to test for differences in progression-free survival (PFS) and toxicity bet...

journal_title：Cancer

authors： Einstein MH,Novetsky AP,Garg M,Hailpern SM,Huang GS,Glueck A,Fields AL,Kalnicki S,Goldberg GL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal...

journal_title：Cancer

authors： Gotoh A,Kitazawa S,Mizuno Y,Takenaka A,Arakawa S,Matsumoto O,Kitazawa R,Fujimori T,Maeda S,Kamidono S

更新日期：1993-05-01 00:00:00

abstract：:The prevalence of variant alkaline phosphatase in the serum of 335 southern African blacks with hepatocellular carcinoma was determined using polyacrylamide gel electrophoresis. The isoenzyme was detected in 2% (seven of 335) of the patients: it could not be found in the serum of 300 matched, healthy individuals or in...

journal_title：Cancer

authors： Bukofzer S,Kew MC,Rowe P

更新日期：1988-09-01 00:00:00

abstract：:Seventeen patients with carcinoma confined to the pancreas and the peripancreatic area received preoperative radiation therapy in an attempt to increase the resectability rate and to reduce the incidence of recurrence. The tumors were considered either unresectable or of borderline resectability. The radiation dose ra...

journal_title：Cancer

authors： Pilepich MV,Miller HH

更新日期：1980-11-01 00:00:00

abstract：:Twenty patients with locally advanced and/or metastatic transitional cell cancer of the urinary tract were treated with cyclophosphamide 500 mg/m2, Adriamycin (doxorubicin) 40 mg/m2 and cis-platinum (CDDP) 40 mg/m2 given every three weeks for 2 cycles, alternating with methotrexate 40 mg/m2 weekly for six weeks (CAP-M...

journal_title：Cancer

authors： Citrin DL,Hogan TF,Davis TE

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...

journal_title：Cancer

authors： Campanella C,Rappa F,Sciumè C,Marino Gammazza A,Barone R,Bucchieri F,David S,Curcurù G,Caruso Bavisotto C,Pitruzzella A,Geraci G,Modica G,Farina F,Zummo G,Fais S,Conway de Macario E,Macario AJ,Cappello F

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-ti...

journal_title：Cancer

authors： Lynch HT,Kaurah P,Wirtzfeld D,Rubinstein WS,Weissman S,Lynch JF,Grady W,Wiyrick S,Senz J,Huntsman DG

更新日期：2008-06-15 00:00:00

abstract：:A retrospective study of 702 patients with clinically positive nodes associated with squamous cell carcinoma of the oral cavity, supraglottic larynx, and hypopharynx observed from 1954 to 1968 was done. The policies of treatment for the neck were not standardized during those years. Three hundred eleven patients who s...

journal_title：Cancer

authors： Jesse RH,Fletcher GH

更新日期：1977-02-01 00:00:00

abstract：:The records of 12 patients with a diagnosis of pinealoma or ectopic pinealoma irradiated at Montefiore Hospital and Medical Center between 1961 and 1971 were reviewed. Diagnosis was made clinically and radiographically. Histology is available in three cases. Eight cases were treated with small fields (4 X 4 to 6 X 8 c...

journal_title：Cancer

authors： Mincer F,Meltzer J,Botstein C

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Shan J,Huang X,Garcia-Manero G,Faderl S,Ravandi-Kashani F,Verstovsek S,Beth Rios M,Cortes J

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Primary small cell carcinoma arising in organs other than the lung were thought to be relatively rare. However, with the increasing technical sophistication of pathology departments, tumors with foci of small cell neuroendocrine components are being identified more frequently. The pattern of disease involvem...

journal_title：Cancer

authors： Lyster MT,Kies MS,Kuzel TM

更新日期：1994-12-15 00:00:00

abstract：:An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...

journal_title：Cancer

authors： Kubota T,Hirano A,Sato K,Yamamoto S

更新日期：1985-02-15 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with gastrointestinal stromal tumors (GISTs), but most patients eventually develop resistance and progress. Dasatinib is a potent inhibitor of BCR-ABL, KIT, and SRC family kinases as well as imatinib-resistant cells. In GISTs, response e...

journal_title：Cancer

authors： Montemurro M,Cioffi A,Dômont J,Rutkowski P,Roth AD,von Moos R,Inauen R,Toulmonde M,Burkhard RO,Knuesli C,Bauer S,Cassier P,Schwarb H,Le Cesne A,Koeberle D,Bärtschi D,Dietrich D,Biaggi C,Prior J,Leyvraz S

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

journal_title：Cancer

authors： Deligdisch L,Miranda C,Barba J,Gil J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Several investigators have reported the ability to establish xenografts in nude mice from children with neuroblastomas, but a correlation of prognosis with this establishment and the growth patterns of the neuroblastomas has not been reported. METHODS:Tumor specimens from 58 children with neuroblastomas wer...

journal_title：Cancer

authors： George BA,Yanik G,Wells RJ,Martin LW,Soukup S,Ballard ET,Gartside PS,Lampkin BC

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Estimates of the fecal occult blood test (FOBT) (Hemoccult II) sensitivity differed widely between screening trials and led to divergent conclusions on the effects of FOBT screening. We used microsimulation modeling to estimate a preclinical colorectal cancer (CRC) duration and sensitivity for unrehydrated F...

journal_title：Cancer

authors： Lansdorp-Vogelaar I,van Ballegooijen M,Boer R,Zauber A,Habbema JD

更新日期：2009-06-01 00:00:00

abstract：:The authors treated 32 patients with Stage IIIB or IV non-small cell lung cancer (NSCLC) with an outpatient regimen of edatrexate (10-ethyl-10-deaza-aminopterin) (10-EdAM) on days 1 and 8, cyclophosphamide on day 1, and cisplatin on day 1, repeated every 3 weeks with dose modification. The 22 men and 10 women (median ...

journal_title：Cancer

authors： Lee JS,Libshitz HI,Fossella FV,Murphy WK,Pang AC,Lippman SM,Shin DM,Dimery IW,Glisson BS,Hong WK

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The presence of tumor cells in peritoneal washing cytology specimens taken during surgery affects the staging of many gynecologic malignancies. Peritoneal washings are often collected routinely, even in cases of presumed benign disease. This study was designed to address whether evaluation of these specimens...

journal_title：Cancer

authors： Sharifi S,Ducatman BS,Wang HH,Fraser JL

更新日期：1999-10-25 00:00:00

abstract：:Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...

journal_title：Cancer

authors： Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman H

更新日期：1980-01-15 00:00:00

abstract：:Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a...

journal_title：Cancer

authors： Mottolese M,Venturo I,Rinaldi M,Campioni N,Aluffi A,Curcio CG,Donnorso RP,Natali PG

更新日期：1989-12-15 00:00:00

abstract：:Thirty-eight metastatic breast cancer patients were treated with aminoglutethimide. All patients had progressive metastatic disease following initial response to Tamoxifen therapy. Thirty-two patients were evaluable for response, of these, two patients (6%) had complete remission, 13 patients (41%) had partial respons...

journal_title：Cancer

authors： Buzdar AU,Powell KC,Legha SS,Blumenschein GR

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMP) are a gene family of zinc enzymes capable of degrading almost all of the extracellular matrix macromolecules in vivo. Their enzymic activities are believed to be responsible for tumor invasion and metastasis. METHODS:In this study, using peroxidase-antiperoxidase method, mono...

journal_title：Cancer

authors： Shima I,Sasaguri Y,Kusukawa J,Yamana H,Fujita H,Kakegawa T,Morimatsu M

更新日期：1992-12-15 00:00:00