Abstract:
BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires specialized observer training and suffers from inter- and intraobserver variability. Furthermore, the categoric scales make it difficult to distinguish small differences in mammographic appearance. To address these limitations, automated analysis techniques that characterize mammographic density on a continuous scale have been considered, but as yet, these have been evaluated only for their ability to reproduce subjective classifications of mammographic parenchyma. METHODS:In this study, using a nested case-control design, the authors evaluated the direct association between breast carcinoma risk and quantitative image features derived from automated analysis of digitized film mammograms. Two parameters, one describing the distribution of breast tissue density as reflected by brightness of the mammogram (regional skewness) and the other characterizing texture (fractal dimension), were calculated for images from 708 subjects identified from the Canadian National Breast Screening Study. RESULTS:These parameters were evaluated for their ability to distinguish cases (those women who developed breast carcinoma) from controls. It was found that both the skewness and fractal parameters were significantly related to risk of developing breast carcinoma. CONCLUSIONS:Although the relative risk estimates were moderate (typically > 2.0) and less than those from subjective classification or for an interactive computer method the authors have previously described, they are comparable to other risk factors for the disease. The observer independence and reproducibility of the automated methods may facilitate their more widespread use.
journal_name
Cancerjournal_title
Cancerauthors
Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NFdoi
10.1002/(sici)1097-0142(19970701)80:1<66::aid-cncrsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
66-74issue
1eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19970701)80:1<66::AID-CNCRjournal_volume
80pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Colonoscopic screening has increased detection of malignant colonic polyps (MPs). The goal of this study was to analyze trends and patterns in the surgical treatment of MPs and to assess outcomes as measured by lymph node retrieval and patient survival. METHODS:The Surveillance, Epidemiology, and End Result...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25657
更新日期:2011-03-01 00:00:00
abstract::A number of cases of sinusoidal hematolymphoid malignancy ("malignant histiocytosis") in which early lymph node biopsies have not allowed clear separation from benign histiocytic disorders have been observed. Nine such cases in which only a follow-up lymph node biopsy documented their malignant nature are reported. Se...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1681::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:Primary lymphomas of the uterus or cervix are so rare that treatment series of single institutions consist of very small numbers of patients, making standard treatment difficult to define. The outcome of patients treated with a combination of chemotherapy and radiation therapy was analyzed for all but patien...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950501)75:9<2392::aid-cncr2820
更新日期:1995-05-01 00:00:00
abstract::Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mamm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)63:9<1685::aid-cncr2820
更新日期:1989-05-01 00:00:00
abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.2820741314
更新日期:1994-07-01 00:00:00
abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:The role of the interaction between tumor cells and inflammatory cells in nonsmall cell lung carcinoma (NSCLC) is unclear. In this study, the authors assessed the prognostic impact of intratumoral cluster of differentiation 66b (carcinoembryonic antigen-related cell adhesion molecule 8 [CD66b])-positive neut...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26456
更新日期:2012-03-15 00:00:00
abstract::To evaluate the role of chemotherapy in local control of primary breast cancer, the incidence of local failure was evaluated in 768 patients treated with surgery and adjuvant, combination chemotherapy that contained fluorouracil, doxorubicin, and cyclophosphamide (FAC) at our institute between 1974 and 1982. Of these ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<394::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-05-15 00:00:00
abstract:BACKGROUND:A review of the literature indicated variable underestimation rates for breast core-needle biopsy (CNB) based on generally small series. In this article, the authors present precise estimates for overall underestimation and for categories of histologic underestimates (including categories that reflect contem...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.22435
更新日期:2007-02-01 00:00:00
abstract::The immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen (CALLA)-positive and CALLA-negative T-acute lymphoblastic leukemia (ALL) and of CALLA-positive non-T, non-B ALL (common ALL) of childhood were compared. Twenty-seven percent of children with T-ALL had blasts that expressed CA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870615)59:12<2020::aid-cncr282
更新日期:1987-06-15 00:00:00
abstract:LAY SUMMARY:Cancer has substantial economic impacts for patients, their families and/or caregivers, employers, and the health care system. However, there is only limited understanding of how economic issues can affect access to cancer care services and the receipt of high-quality cancer care. Health economics research ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33343
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Insulin-like growth factor I (IGF-I) is a potent mitogen for breast cancer cells. The majority of IGF-I in plasma is bound to IGF binding proteins (IGFBPs), which modulate the biologic effects of IGF-I. METHODS:Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between 40 postmenopausal brea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940715)74:2<618::aid-cncr28207
更新日期:1994-07-15 00:00:00
abstract::The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the efficacy of adding chronic, intermittent, low-dose vinorelbine to gefitinib treatment for patients who had adenocarcinoma of the lung who failed>or=2 regimens of chemotherapy. METHODS:Patients were randomized into 2 arms: Oral gefitinib 250 mg daily (the G arm) ...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.22616
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory. In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24038
更新日期:2009-02-01 00:00:00
abstract::A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197905)43:5<1872::aid-cncr282043
更新日期:1979-05-01 00:00:00
abstract::To surgery, radiation, and chemotherapy for cancer has been added a fourth modality: multidisciplinary therapy, which is improving the survival and cure rate among children. Specialists working together in a coordinated effort suspect, confirm, then treat cancer; follow and rehabilitate the patient; analyze and report...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<876::aid-cncr282035
更新日期:1975-03-01 00:00:00
abstract::A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2324::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860315)57:6<1092::aid-cncr2820
更新日期:1986-03-15 00:00:00
abstract::A marked increase in specific immunogenicity of tumor cells is induced upon incorporation of cholesteryl hemisuccinate (CHS) into the cell membrane, which presumably promotes the expression of latent tumor-associated antigens. Immunotherapy with CHS-treated and irradiated tumor cells as vaccine was found to be very ef...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19860801)58:3<650::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract::Because of the rarity of the primary carcinoma of the female urethra, there has been limited experience of individual institutions in management of this disease. Treatment by radiation alone required radium implant skill in early cases and individualized consideration for integrating external and internal irradiation ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197809)42:3<1177::aid-cncr282042
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Patients with locoregional carcinoma of the esophagus or gastroesophageal junction have a poor survival rate after surgery. Preoperative chemotherapy or chemoradiotherapy has not improved the outcome for these patients. Our study was designed to assess the feasibility of preoperative induction combination ch...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010715)92:2<279::aid-cncr1320>
更新日期:2001-07-15 00:00:00
abstract:BACKGROUND:Pelvic irradiation to patients with prostate cancer is accompanied by urinary and intestinal reactions. In men older than 60 years, treatment-induced problems should be evaluated in relation to problems in an age-matched nonirradiated population. METHODS:In the present study, problems in the urinary tract a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941101)74:9<2520::aid-cncr2820
更新日期:1994-11-01 00:00:00
abstract::The purpose of this study was to determine (1) the number and activity of natural killer (NK) cells in children with acute leukemia at different stages of their disease; and (2) the effect of interleukin-2 (IL-2) in enhancing NK activity of these patients' cells. The mean percentage of Leu 11+ NK cells in patients at ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2913::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract::The DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocarcinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K-ras codon 12, 1 in K-ras codon 13, 1 in K-ras codon 61, and 1 in N-ras codon 12. The inciden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820690509
更新日期:1992-03-01 00:00:00
abstract::The authors draw on the lessons highlighted in preceding articles in the current supplement to provide recommendations for cancer screening intervention research and to highlight some of the many questions that will require further investigation. ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.20510
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Smoldering multiple myeloma (SMM) presents a high risk of progression to symptomatic MM (sy-MM). Herein, we analyzed some predictors of development of sy-MM. In 144 patients with SMM, we also compared the risk of progression predicted by bone marrow plasma cell (BMPC) involvement on the bone marrow biopsy (B...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27657
更新日期:2012-11-15 00:00:00
abstract::Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1696::aid-cncr2820
更新日期:1985-10-01 00:00:00