Abstract:
BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal human kidney tissues and tissues from 42 human renal cell carcinomas obtained at operation or autopsy. RESULTS:In normal renal tissues, the distal tubules and collecting ducts showed positive immunostaining. PTHrP was detected in 40 of 42 renal cell carcinoma tissues (95%). Histopathologically, the granular cell subtypes of renal cell carcinomas tended to be more strongly positive than the clear cell subtypes. There was no significant correlation between the level of immunostaining and each patient's serum calcium level. CONCLUSION:PTHrP was commonly observed in renal cell carcinomas, and no significant correlation was seen between the intensity of PTHrP staining and the serum calcium level.
journal_name
Cancerjournal_title
Cancerauthors
Gotoh A,Kitazawa S,Mizuno Y,Takenaka A,Arakawa S,Matsumoto O,Kitazawa R,Fujimori T,Maeda S,Kamidono Sdoi
10.1002/1097-0142(19930501)71:9<2803::aid-cncr2820subject
Has Abstractpub_date
1993-05-01 00:00:00pages
2803-6issue
9eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Studies of colorectal adenocarcinoma (CRC) indicate a higher mortality rate for African Americans compared with Caucasians in the United States. In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20337
更新日期:2004-07-01 00:00:00
abstract::Most patients with colorectal carcinoma undergo attempts at curative surgery. However, some present with metastatic disease and many others ultimately relapse. Most recurrences of colorectal cancer are not resectable and require nonsurgical approaches such as chemotherapy and radiation therapy directed against local r...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930615)71:12+<4278::aid-cncr28
更新日期:1993-06-15 00:00:00
abstract::Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19940815)74:4+<1484::aid-cncr282
更新日期:1994-08-15 00:00:00
abstract::Retinitis pigmentosa, a hereditary disease characterized by progressive retinal degeneration and blindness, has been associated with numerous diseases. We report the first association between retinitis pigmentosa and colon cancer in 3 of 53 hospitalized patients with retinitis pigmentosa at the Massachusetts General H...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800601)45:11<2897::aid-cncr282
更新日期:1980-06-01 00:00:00
abstract::Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900201)65:3+<634::aid-cncr2820
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Anemia in patients receiving chemotherapy can be ameliorated with recombinant human erythropoietin (rHuEPO), which is administered one to three times per week. Darbepoetin alpha, a new erythropoietic agent, has longer serum residence time, allowing it to be administered less frequently. METHODS:Patients (n ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.11186
更新日期:2003-03-01 00:00:00
abstract::In nine patients who had undergone trans-sphenoidal hypophysectomy, prolactin dynamics were studied with intravenous thyrotropin releasing hormone (TRH). Residual prolactin secretory reserve was demonstrated in seven. Five patients were TRH tested both before and after trans-sphenoidal hypophysectomy. Hypophysectomy d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2254::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract::In this study the authors applied flow cytometric DNA-ploidy analysis to multiple female genital tract malignant tumors in 43 patients, most of whom (n = 37) had bilateral ovarian cancer. An algorithm was developed for calculation of the likelihood ratio of the probabilities that measured DNA index differences between...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1990-10-15 00:00:00
abstract:BACKGROUND:The ability to divide subsets of patients with glial neoplasms into prognostic groups currently is limited because only a few clinical and pathologic variables are available. The goal of this investigation was to identify biologic factors of potential prognostic value in patients with cerebral gliomas. METH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3<920::aid-cncr28207
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, the potential prognostic value of DNA ploidy in vulvar melanoma has not been evaluated in previous series. METHODS:Clinical data and follow-up information were retrieved from the hospital records of 75 patients treated from 1956 to 1987. Histopathologic specimens were reviewed for...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950101)75:1<72::aid-cncr282075
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:A sedentary life style has been consistently associated with an increased risk of colon cancer, but the evidence for its association with breast and other gynecologic cancers is limited. METHODS:Occupational information for 3783 incident patients with cancer (breast, 2736; corpus uteri, 452; and ovary, 595)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3620::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract::In January, 1972, the Southwest Oncology Group initiated two randomized studies for patients with advanced breast cancer. The study for patients with prior chemotherapy showed a 33% response rate with adriamycin. The study for patients without previous chemotherapy consisted of three treatment regimens; a weekly repea...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197607)38:1<13::aid-cncr28203801
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Malignant peritoneal mesothelioma is a rare and fatal disease. Until recently, the treatment options were very limited and ineffective. The new comprehensive approach of cytoreductive surgery with perioperative intraperitoneal chemotherapy offers improved survival rates at a cost of considerable morbidity an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20836
更新日期:2005-02-15 00:00:00
abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19931015)72:8<2517::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract::Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...
journal_title:Cancer
pub_type: 杂志文章,收录出版,评审
doi:10.1002/cncr.24236
更新日期:2009-05-15 00:00:00
abstract::This survey of the incidence of melanoma in New South Wales, Australia, from 1970 to 1976 revealed a doubling of incidence in the seven year period. The most marked rise occurred in 1972. A marked preponderance of leg melanoma in women and trunk melanoma in men was noted. The incidence of melanoma in men continues to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800715)46:2<427::aid-cncr28204
更新日期:1980-07-15 00:00:00
abstract::On account of the functioning bigonads, true hermaphrodites show a wide range of morphological anomalies. The patient under discussion had an ovary on one side and an ovotestis on the other side; both of them functioned to some extent to produce a rudimentary uterus, fallopian tubes and a few Woolfian remnants. The ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2726::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871015)60:8<1842::aid-cncr2820
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:Antibacterial prophylaxis with quinolone antibiotics has resulted in an increase in streptococcal infections among bone marrow transplantation (BMT) recipients with myelosuppression. Oral ulceration (mucositis), which frequently occurs as a consequence of chemotherapy, has been implicated as a significant po...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Some patients with gastric carcinoma experience local disease recurrence despite undergoing curative resection of the tumor and regional lymph nodes (LNs), suggesting the presence of occult micrometastases. To evaluate the presence of gastric carcinoma micrometastasis in patients with otherwise histologicall...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2056::aid-cncr1545
更新日期:2001-10-15 00:00:00
abstract::Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II--IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197906)43:6<2227::aid-cncr282043
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Exercise is a modifiable lifestyle risk factor associated with prostate cancer risk reduction. However, whether this association is different as a function of race is unclear. In the current study, the authors attempted to characterize the link between exercise and prostate cancer (CaP) in white and black Am...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27791
更新日期:2013-04-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered intraperitoneally in combination with multidrug chemotherapy using methotrexate (M), vinblastine (V), doxorubicin (A), and cisplatin (C, or for the combination, MVAC) to C3H/He mice (5-week-old females) after experimental carcinoma, MBT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<997::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract:BACKGROUND:The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (NSCLC) by the administration of carboplatin plus gemcitabine followed by of paclitaxel. METHODS:Patients with Stage IIIB (pleural effusion) or ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010701)92:1<146::aid-cncr1302>
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:To optimize fotemustine chemotherapy, the authors considered how to combine independent Phase II trials to predict the risk of first occurrence of severe toxicity as a function of initial patient characteristics. METHODS:Clinical data from six Phase II trials were collected. Of the 478 patients enrolled 442...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25961
更新日期:2011-08-15 00:00:00
abstract:BACKGROUND:Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin-based chemotherapy. However, 10-20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities offer only a chance for short pallia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10671
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:Indium-111 labeled antiferritin targets 95% of all Hodgkin's disease lesions with a diameter of 1 cm or more. Subsequent treatment with yttrium-90 labeled antiferritin secures a high response rate in patients with recurrent Hodgkin's disease. METHODS:A total of 87 patients were entered on one of three diffe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12+<2721::aid-
更新日期:1997-12-15 00:00:00
abstract::Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23938
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00