Abstract:
:The prevalence of variant alkaline phosphatase in the serum of 335 southern African blacks with hepatocellular carcinoma was determined using polyacrylamide gel electrophoresis. The isoenzyme was detected in 2% (seven of 335) of the patients: it could not be found in the serum of 300 matched, healthy individuals or in 56 patients with various benign hepatic diseases. Variant alkaline phosphatase is thus of little use as a diagnostic marker of hepatocellular carcinoma in southern African blacks. The reported prevalence of this isoenzyme in hepatocellular carcinoma ranges between 3% and 31%. Higher frequencies usually are recorded in populations with a low incidence of the tumor, and the lowest frequencies have been found in Chinese patients. Our finding of variant alkaline phosphatase in only 2% of another high incidence population fits this trend. Patients with tumors that secreted the variant isoenzyme had a significantly higher serum total alkaline phosphatase activity than those with tumors lacking this property.
journal_name
Cancerjournal_title
Cancerauthors
Bukofzer S,Kew MC,Rowe Pdoi
10.1002/1097-0142(19880901)62:5<978::aid-cncr28206subject
Has Abstractpub_date
1988-09-01 00:00:00pages
978-81issue
5eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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