The prevalence of variant alkaline phosphatase in hepatocellular carcinoma in southern African blacks.

Abstract:

:The prevalence of variant alkaline phosphatase in the serum of 335 southern African blacks with hepatocellular carcinoma was determined using polyacrylamide gel electrophoresis. The isoenzyme was detected in 2% (seven of 335) of the patients: it could not be found in the serum of 300 matched, healthy individuals or in 56 patients with various benign hepatic diseases. Variant alkaline phosphatase is thus of little use as a diagnostic marker of hepatocellular carcinoma in southern African blacks. The reported prevalence of this isoenzyme in hepatocellular carcinoma ranges between 3% and 31%. Higher frequencies usually are recorded in populations with a low incidence of the tumor, and the lowest frequencies have been found in Chinese patients. Our finding of variant alkaline phosphatase in only 2% of another high incidence population fits this trend. Patients with tumors that secreted the variant isoenzyme had a significantly higher serum total alkaline phosphatase activity than those with tumors lacking this property.

journal_name

Cancer

journal_title

Cancer

authors

Bukofzer S,Kew MC,Rowe P

doi

10.1002/1097-0142(19880901)62:5<978::aid-cncr28206

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

978-81

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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