Factor VIII related antigen in adenomatoid tumors: implications for histogenesis.

Abstract:

:The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When these results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumor did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.

journal_name

Cancer

journal_title

Cancer

authors

Bell DA,Flotte TJ

doi

10.1002/1097-0142(19820901)50:5<932::aid-cncr28205

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

932-8

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

50

pub_type

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