Current trends for the use of androgen deprivation therapy in conjunction with radiotherapy for patients with unfavorable intermediate-risk, high-risk, localized, and locally advanced prostate cancer.


:Androgen deprivation therapy (ADT) is now a well-established standard of care in combination with definitive radiotherapy for patients with unfavorable intermediate-risk to high-risk locally advanced prostate cancer. It is also well established that combination modality treatment with ADT and radiotherapy is superior to either of these modalities alone for the treatment of patients with high-risk locally advanced disease. Current treatment guidelines for prostate cancer in the United States are based on the estimated risk of recurrence and death. This review examines the clinical evidence underpinning the use of ADT and radiotherapy among patients with high-risk localized and locally advanced disease in the United States. This review also considers the rationale for moving from traditional luteinizing hormone-releasing hormone agonists to more recently developed gonadotrophin-releasing hormone antagonists.






Roach M 3rd




Has Abstract


2014-06-01 00:00:00














  • Dose-escalation study of vemurafenib with sorafenib or crizotinib in patients with BRAF-mutated advanced cancers.

    abstract:BACKGROUND:BRAF inhibitors are effective in melanoma and other cancers with BRAF mutations; however, patients ultimately develop therapeutic resistance through the activation of alternative signaling pathways such as RAF/RAS or MET. The authors hypothesized that combining the BRAF inhibitor vemurafenib with either the ...


    pub_type: 杂志文章


    authors: Janku F,Sakamuri D,Kato S,Huang HJ,Call SG,Naing A,Holley VR,Patel SP,Amaria RN,Falchook GS,Piha-Paul SA,Zinner RG,Tsimberidou AM,Hong DS,Meric-Bernstam F

    更新日期:2021-02-01 00:00:00

  • Topical chemotherapy of lentigo maligna with 5-fluorouracil.

    abstract::Three patients with biopsy-proven lentigo maligna were treated with topical 5-fluorouracil. Treatment consisted of twice daily application of 5% 5-fluorouracil cream for 13, 6, and 9 weeks, respectively. Two patients demonstrated presence of invasive melanoma; in one the melanoma was evident before chemotherapy, and i...


    pub_type: 杂志文章


    authors: Litwin MS,Krementz ET,Mansell PW,Reed RJ

    更新日期:1975-03-01 00:00:00

  • How well do medical oncologists' perceptions reflect their patients' reported physical and psychosocial problems? Data from a survey of five oncologists.

    abstract:BACKGROUND:Modern cancer treatments can cure or prolong patients' lives. However, the associated physical and psychosocial problems can detrimentally affect patients' compliance with treatment and, ultimately, their outcomes. Therefore, oncologists need to recognize the problems experienced by their patients and, when ...


    pub_type: 杂志文章


    authors: Newell S,Sanson-Fisher RW,Girgis A,Bonaventura A

    更新日期:1998-10-15 00:00:00

  • Malignant rhabdoid tumor of the pelvis.

    abstract::An extrarenal malignant rhabdoid tumor (MRT) of the pelvis in a 14-year-old girl is described. The location of the tumor and age of the patient appear to be unique. The neoplasm is histologically and ultrastructurally identical to malignant rhabdoid tumor of the kidney seen in infants and very young children. The tumo...


    pub_type: 杂志文章


    authors: Frierson HF Jr,Mills SE,Innes DJ Jr

    更新日期:1985-05-01 00:00:00

  • Concurrent radiation therapy, 5-fluorouracil, and cisplatin for stage II, III, and IV, node-negative, squamous cell head and neck cancer. Results and surgical implications.

    abstract:METHODS:Between 1983 and 1989, 42 patients with Stage II, III, and IV, node-negative, squamous cell head and neck cancer were treated with concurrent 5-fluorouracil, cisplatin, and radiation therapy. Two courses of chemotherapy with 30 Gy of concurrent radiation therapy were to be followed in all patients by definitive...


    pub_type: 临床试验,杂志文章


    authors: Adelstein DJ,Sharan VM,Damm C,Earle AS,Shah AC,Haria CD,Trey JE,Carter SG,Hines JD

    更新日期:1992-12-01 00:00:00

  • A phase II trial of 5-fluorouracil, leucovorin, and recombinant alpha-2b-interferon in advanced adenocarcinoma of the pancreas.

    abstract:BACKGROUND:Preclinical and clinical data suggest that both leucovorin (LV) and interferon (IFN) can augment the cytotoxic effects of 5-fluorouracil (5-FU). Based on the rationale of biochemical double modulation, the current Phase II study was undertaken. METHODS:Thirty-two previously untreated patients with advanced ...


    pub_type: 临床试验,杂志文章


    authors: Scheithauer W,Pfeffel F,Kornek G,Marczell A,Wiltschke C,Funovics J

    更新日期:1992-10-01 00:00:00

  • Codon 13 KRAS mutation predicts patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases.

    abstract:BACKGROUND:Investigations regarding the impact of tumor biology after surgical management of colorectal liver metastasis have focused largely on overall survival. We investigated the impact of codon-specific KRAS mutations on the rates and patterns of recurrence in patients after surgery for colorectal liver metastasis...


    pub_type: 杂志文章


    authors: Margonis GA,Kim Y,Sasaki K,Samaha M,Amini N,Pawlik TM

    更新日期:2016-09-01 00:00:00

  • Issues in the consideration of intervention strategies in long-term survivors of childhood cancer.

    abstract::With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...


    pub_type: 杂志文章


    authors: Robison LL

    更新日期:1993-05-15 00:00:00

  • Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma.

    abstract::Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant p...


    pub_type: 杂志文章


    authors: Lippman SM,Grogan TM,Spier CM,Koopmann CF Jr,Gall EP,Shimm DS,Durie BG

    更新日期:1987-03-01 00:00:00

  • Histology and DNA contents of a secondary malignancy arising in a mature residual lesion six years after chemotherapy for a disseminated nonseminomatous testicular tumor.

    abstract::The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...


    pub_type: 杂志文章


    authors: Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

    更新日期:1986-07-15 00:00:00

  • Second solid cancers after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:The authors reviewed the case files of 926 consecutive patients who underwent allo-HSCT at their institution b...


    pub_type: 杂志文章


    authors: Gallagher G,Forrest DL

    更新日期:2007-01-01 00:00:00

  • Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation.

    abstract:BACKGROUND:Radiofrequency (RF)-induced tissue coagulation represents a new approach for the thermal destruction of tumors within the liver. The purpose of the current study was to 1) assess technique safety; 2) determine the extent and evolution of induced cellular damage; and 3) correlate the observed pathologic effec...


    pub_type: 杂志文章


    authors: Goldberg SN,Gazelle GS,Compton CC,Mueller PR,Tanabe KK

    更新日期:2000-06-01 00:00:00

  • Neurodevelopmental anomalies in children with neuroblastoma.

    abstract:BACKGROUND:Case reports have associated neuroblastoma, a cancer derived from the embryonal neural crest, with aganglionosis coli and neurofibromatosis type I. The aim of the current study was to test the hypothesis that neuroblastoma is part of a global defect in neurodevelopment. METHODS:Neuropathologic findings from...


    pub_type: 杂志文章


    authors: Blatt J,Hamilton RL

    更新日期:1998-04-15 00:00:00

  • Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection.

    abstract:BACKGROUND:In Japan, where liver transplantation has not been used to treat patients with hepatocellular carcinoma (HCC), percutaneous ethanol injection (PEI) has been employed for those with small HCCs that are not amenable to surgical resection. In the current study, the authors evaluated PEI as a treatment for HCC p...


    pub_type: 杂志文章


    authors: Hasegawa S,Yamasaki N,Hiwaki T,Sako K,Komorizono Y,Baba Y,Imamura Y,Kubozono O,Yoshida A,Arima T

    更新日期:1999-11-01 00:00:00

  • Recurrent adult nephroblastoma. Long-term remission after surgery plus adjuvant high-dose chemotherapy, radiation therapy, and allogeneic bone marrow transplantation.

    abstract::The authors report a case of Stage IV, unfavorable histologic type adult nephroblastoma. The patient was treated with multimodal therapy: combination chemotherapy consisting of cyclophosphamide, doxorubicin, cisplatin, and etoposide succeeded by nephrectomy and radiation therapy. After a disease-free period of 27 mont...


    pub_type: 杂志文章


    authors: Hupperets PS,Havenith MG,Blijham GH

    更新日期:1992-06-15 00:00:00

  • Extraskeletal telangiectatic osteosarcoma.

    abstract::The first three well-documented cases of pure, extraskeletal telangiectatic osteosarcoma of the soft tissues are presented in this article. The distinctive gross features were a predominance of large, blood-filled spaces, which, on histologic examination, were large blood-filled cavities in association with cyst-like ...


    pub_type: 杂志文章


    authors: Mirra JM,Fain JS,Ward WG,Eckardt JJ,Eilber F,Rosen G

    更新日期:1993-05-15 00:00:00

  • Risk of venous thromboembolism in patients with non-Hodgkin lymphoma surviving blood or marrow transplantation.

    abstract:BACKGROUND:Patients with non-Hodgkin lymphoma (NHL) have an increased risk of venous thromboembolism (VTE), particularly when they are receiving treatment. Blood or marrow transplantation (BMT) is recommended for relapsed/refractory NHL, and the risk of VTE after these patients undergo BMT is uncertain. METHODS:Patien...


    pub_type: 杂志文章


    authors: Gangaraju R,Chen Y,Hageman L,Wu J,Francisco L,Kung M,Ness E,Parman M,Weisdorf DJ,Forman SJ,Arora M,Armenian SH,Bhatia S

    更新日期:2019-12-15 00:00:00

  • Cis-diamminedichloride platinum II (DDP) in the treatment of penile carcinoma.

    abstract::Cis-diamminedichloride platinum II (DDP) was administered to eight patients with epidermoid carcinoma of the penis. Three of six adequately treated patients had an objective response: one patient achieved complete remission of 7 months duration and 2 patients had partial remissions of 8 and 2 months, respectively. DDP...


    pub_type: 杂志文章


    authors: Sklaroff RB,Yagoda A

    更新日期:1979-11-01 00:00:00

  • Immune complexes, serum proteins, cell-mediated immunity, and immune regulation in patients with squamous cell carcinoma of the head and neck.

    abstract::A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum prot...


    pub_type: 杂志文章


    authors: Veltri RW,Rodman SM,Maxim PE,Baseler MW,Sprinkle PM

    更新日期:1986-06-15 00:00:00

  • Cancer-related fatigue: implications for breast cancer survivors.

    abstract::Cancer-related fatigue (CRF) has been documented as 1 of the most distressing symptoms reported by breast cancer survivors. CRF affects functioning and impacts quality of life. Possible causal factors include physical conditions, affective and cognitive states, proinflammatory cytokines, and metabolic factors. Several...


    pub_type: 杂志文章,评审


    authors: Berger AM,Gerber LH,Mayer DK

    更新日期:2012-04-15 00:00:00

  • Clinical features of patients with stage IIIB and IV bronchioloalveolar carcinoma of the lung.

    abstract:BACKGROUND:The incidence of bronchioloalveolar carcinoma of the lung (BAC), a pathologically distinct type of nonsmall cell lung carcinoma (NSCLC), appears to be rising. In this study, the authors compared data on the clinical presentation and clinical courses of patients with Stage IIIB and IV BAC with data on other t...


    pub_type: 杂志文章


    authors: Breathnach OS,Ishibe N,Williams J,Linnoila RI,Caporaso N,Johnson BE

    更新日期:1999-10-01 00:00:00

  • Toxicity and efficacy of combined radioimmunotherapy and bevacizumab in a mouse model of medullary thyroid carcinoma.

    abstract:BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...


    pub_type: 杂志文章


    authors: Salaun PY,Bodet-Milin C,Frampas E,Oudoux A,Saï-Maurel C,Faivre-Chauvet A,Barbet J,Paris F,Kraeber-Bodéré F

    更新日期:2010-02-15 00:00:00

  • Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study.

    abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...


    pub_type: 杂志文章


    authors: Howell CR,Wilson CL,Ehrhardt MJ,Partin RE,Kaste SC,Lanctot JQ,Pui CH,Robison LL,Hudson MM,Ness KK

    更新日期:2018-03-01 00:00:00

  • Primary chemotherapy for obstructive jaundice caused by intermediate-grade non-Hodgkin lymphoma.

    abstract:BACKGROUND:Advanced non-Hodgkin lymphoma (NHL) usually is treated with doxorubicin-based combination chemotherapy. Because doxorubicin is excreted by the biliary route, many authorities recommend alternative initial interventions in patients with NHL causing obstructive jaundice. METHODS:The authors retrospectively re...


    pub_type: 杂志文章


    authors: Dudgeon DJ,Brower M

    更新日期:1993-05-01 00:00:00

  • Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.

    abstract:BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...


    pub_type: 杂志文章


    authors: Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

    更新日期:2006-05-15 00:00:00

  • Malignant "Triton" tumors. Natural history and immunohistochemistry of nine new cases with literature review.

    abstract::Malignant schwannomas with rhabdomyoblastic differentiation have been termed malignant "Triton" tumors (MTT). To define the natural history of MTT, we have analyzed our experience (9 cases, the largest series reported) in combination with the 27 previously described in the literature (total 36 cases). This study was i...


    pub_type: 杂志文章


    authors: Brooks JS,Freeman M,Enterline HT

    更新日期:1985-06-01 00:00:00

  • Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.

    abstract::The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy. Response (PR + CR) was obtained in 14 patients (40%) of a median duration of five months. Among the 14 responding patients, 10 were resistant to previous endocrine th...


    pub_type: 杂志文章


    authors: Mouridsen HT,Kristensen D,Nielsen JH,Dombernowsky P

    更新日期:1980-07-15 00:00:00

  • Smoking versus quitting and fear of cancer recurrence 9 years after diagnosis in the American Cancer Society's Longitudinal Study of Cancer Survivors-I (SCS-I).

    abstract:BACKGROUND:Fear of cancer recurrence (FCR) adversely affects quality of life. Cigarette smoking increases the risk of recurrence and may exacerbate FCR among survivors who smoke. FCR also may motivate quitting, but research on whether quitting reduces long-term survivors' FCR is lacking. Among long-term survivors of va...


    pub_type: 杂志文章


    authors: Westmaas JL,Thewes B,Séguin Leclair C,Lebel S

    更新日期:2019-12-01 00:00:00

  • Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.

    abstract:BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...


    pub_type: 杂志文章


    authors: Xu X,Sun TT,Gupta PK,Zhang P,Nasuti JF

    更新日期:2001-06-25 00:00:00

  • Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.

    abstract:BACKGROUND:Ligand activation of peroxisome proliferator-activated receptor gamma (PPARgamma) results in the inhibition of proliferation of various cancer cells. The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglita...


    pub_type: 杂志文章


    authors: Yoshizawa K,Cioca DP,Kawa S,Tanaka E,Kiyosawa K

    更新日期:2002-11-15 00:00:00