Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage.

Abstract:

BACKGROUND:Caveolin-1 plays a regulatory role in several signaling pathways. Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown. METHODS:One hundred thirty surgical specimens of esophageal squamous cell carcinoma were immunohistochemically assessed for caveolin-1 expression by polyclonal antibody. Caveolin-1 immunoreactivity was correlated with patients' clinicopathologic parameters and outcome. RESULTS:Positive caveolin-1 immunostaining was detected in 58 patients (44.6%). Positive caveolin-1 immunostaining correlated positively with pathologic stage (P = 0.029), pN (P = 0.023), and pM (P = 0.018). The overall survival rate was worse in patients with caveolin-1-positive tumors than in patients with caveolin-1-negative tumors (P = 0.0215). Univariate analyses identified caveolin-1 positivity (P = 0.0238), pT (P = 0.0002), pN (P < 0.0001), pM (P = 0.0002), lymphatic invasion (P = 0.0021), and positive surgical margin (P < 0.0001) as negative prognostic predictors. Multivariate analyses indicated that pT (P = 0.0296), pN (P = 0.0003), and a positive surgical margin (P = 0.0452) were independent prognostic factors. CONCLUSIONS:Over-expression of caveolin-1 is associated with lymph node metastasis and a worse prognosis after surgery in esophageal squamous cell carcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Kato K,Hida Y,Miyamoto M,Hashida H,Shinohara T,Itoh T,Okushiba S,Kondo S,Katoh H

subject

Has Abstract

pub_date

2002-02-15 00:00:00

pages

929-33

issue

4

eissn

0008-543X

issn

1097-0142

pii

10.1002/cncr.10329

journal_volume

94

pub_type

杂志文章

相关文献

CANCER文献大全
  • Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial.

    abstract::This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19800715)46:2<386::aid-cncr28204

    authors: Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

    更新日期:1980-07-15 00:00:00

  • Multiple cancers in the prostate. Morphologic features of clinically recognized versus incidental tumors.

    abstract::Multiple independent tumors were identified in specimens from 117 of 234 prostatectomies for clinical adenocarcinoma; there were 266 incidental cancers in these 117 prostates. The clinically detected carcinoma was the largest (or only) tumor in all 202 Stage B cases. However, among 32 Stage A cases (detection by trans...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921101)70:9<2313::aid-cncr2820

    authors: Villers A,McNeal JE,Freiha FS,Stamey TA

    更新日期:1992-11-01 00:00:00

  • Advocacy. Necessary to achieve cancer control goals.

    abstract::As resources become increasingly scarce, oncology professionals and consumers of oncology services are increasingly engaging in advocacy efforts to achieve goals in cancer control. Effective advocacy includes both legislative and direct educational efforts. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911201)68:11+<2540::aid-cncr28

    authors: Berkman B,Stevenson E,Cravedi KG,Davis A,Lawrence W Jr,Mor V,Ostrander V,Rubenstein LJ,Speers M,Wilson K

    更新日期:1991-12-01 00:00:00

  • High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy.

    abstract:BACKGROUND:In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-FU) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. This has enabled them to explore the possibility that the level of expression of thymidyl...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19980501)82:9<1626::aid-cn

    authors: Yeh KH,Shun CT,Chen CL,Lin JT,Lee WJ,Lee PH,Chen YC,Cheng AL

    更新日期:1998-05-01 00:00:00

  • The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site.

    abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22410

    authors: Sève P,Billotey C,Broussolle C,Dumontet C,Mackey JR

    更新日期:2007-01-15 00:00:00

  • Hypercalcemia in small cell (oat cell) carcinoma of the lung. Coincident parathyroid adenoma in one case.

    abstract::Hypercalcemia is very uncommon in small cell (oat cell) carcinoma of the lung. Two cases of this neoplasm associated with symptomatic hypercalcemia are described. Despite normal skeletal roentgenograms, metastatic bone disease was demonstrated by abnormal bone scans and bone biopsies in both patients. The combination ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1067::aid-cncr282036

    authors: Bowman DM,Dubé WJ,Levitt M

    更新日期:1975-09-01 00:00:00

  • Mammography and palpable cancer of the breast.

    abstract::The statistical analysis documented in this article was performed to determine the accuracy of mammography in diagnosing a palpable cancer of the breast. All of the women studied underwent mammography after the discovery of the cancer, which was proven by biopsy; the cancer did not involve the skin. All mammograms tha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880115)61:2<263::aid-cncr28206

    authors: Edeiken S

    更新日期:1988-01-15 00:00:00

  • Prolactin cell carcinoma of the pituitary. Clinicopathologic, immunohistochemical, and ultrastructural study of a case with cranial and extracranial metastases.

    abstract::A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850201)55:3<598::aid-cncr28205

    authors: Scheithauer BW,Randall RV,Laws ER Jr,Kovacs KT,Horvath E,Whitaker MD

    更新日期:1985-02-01 00:00:00

  • Mediterranean Kaposi's sarcoma in the elderly. A randomized study of oral etoposide versus vinblastine.

    abstract:BACKGROUND:This Phase III trial was performed to compare the roles of oral etoposide and intravenous (i.v.) vinblastine in the treatment of Mediterranean Kaposi's Sarcoma (MEKS) in elderly patients with severe disease (Stages II, Ac/B, III, and IV). PATIENTS AND METHODS:Sixty-five patients were randomized to receive e...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19941115)74:10<2873::aid-cncr282

    authors: Brambilla L,Labianca R,Boneschi V,Fossati S,Dallavalle G,Finzi AF,Luporini G

    更新日期:1994-11-15 00:00:00

  • Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer.

    abstract:BACKGROUND:Obesity has been associated with inferior outcomes in operable breast cancer, but the relation between body mass index (BMI) and outcomes by breast cancer subtype has not been previously evaluated. METHODS:The authors evaluated the relation between BMI and outcomes in 3 adjuvant trials coordinated by the Ea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27527

    authors: Sparano JA,Wang M,Zhao F,Stearns V,Martino S,Ligibel JA,Perez EA,Saphner T,Wolff AC,Sledge GW Jr,Wood WC,Fetting J,Davidson NE

    更新日期:2012-12-01 00:00:00

  • Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study.

    abstract::Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810201)47:3<470::aid-cncr28204

    authors: Askin FB,Land VJ,Sullivan MP,Ragab AH,Steuber CP,Dyment PG,Talbert J,Moore T

    更新日期:1981-02-01 00:00:00

  • B-cell lymphoma in severe combined immunodeficiency not associated with the Epstein-Barr virus.

    abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282

    authors: Garcia CR,Brown NA,Schreck R,Stiehm ER,Hudnall SD

    更新日期:1987-12-15 00:00:00

  • Pathologic stage III endometrial carcinoma. Prognostic factors and patterns of recurrence.

    abstract:BACKGROUND:This review was done to assess the outcomes and patterns of recurrence in a group of patients with Stage III endometrial carcinoma that might help guide adjuvant therapy. METHODS:A retrospective review was performed of 105 patients treated from 1970-1990 at three institutions. All patients underwent abdomin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930601)71:11<3697::aid-cncr282

    authors: Greven KM,Lanciano RM,Corn B,Case D,Randall ME

    更新日期:1993-06-01 00:00:00

  • Antitumor electrochemotherapy: new advances in the clinical protocol.

    abstract:BACKGROUND:Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19960301)77:5<956::aid-cnc

    authors: Domenge C,Orlowski S,Luboinski B,De Baere T,Schwaab G,Belehradek J Jr,Mir LM

    更新日期:1996-03-01 00:00:00

  • Breast conservation therapy in the United States following the 1990 National Institutes of Health Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma.

    abstract:BACKGROUND:A National Institutes of Health (NIH) Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma, held in June 1990, recommended breast conservation therapy for the majority of women with Stage I or II breast carcinoma. The authors evaluated the national use of b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lazovich D,Solomon CC,Thomas DB,Moe RE,White E

    更新日期:1999-08-15 00:00:00

  • Conservative treatment of breast cancer. A trial in progress at the Cancer Institute of Milan.

    abstract::The report describes a clinical trial on conservative surgery in progress at the National Cancer Institute of Milan, Italy. The randomized clinical trial compares radical mastectomy with a more conservative procedure consisting of mammary resection plus axillary dissection plus radiotherapy. The resection comprises an...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197706)39:6<2822::aid-cncr282039

    authors: Veronesi U,Banfi A,Saccozzi R,Salvadori B,Zucali R,Uslenghi C,Greco M,Luini A,Rilke F,Sultan L

    更新日期:1977-06-01 00:00:00

  • Prostate carcinoma risk subsequent to diagnosis of benign prostatic hyperplasia: a population-based cohort study in Sweden.

    abstract:BACKGROUND:Pathologically, benign prostatic hyperplasia (BPH) is not considered a precursor for prostate carcinoma. However, because the two conditions share not only a similar hormonal environment within the prostate but also several common risk factors, it is possible that men with BPH may be at increased risk of pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11710

    authors: Chokkalingam AP,Nyrén O,Johansson JE,Gridley G,McLaughlin JK,Adami HO,Hsing AW

    更新日期:2003-10-15 00:00:00

  • Adrenocortical carcinoma: clinical and laboratory observations.

    abstract:BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Wajchenberg BL,Albergaria Pereira MA,Medonca BB,Latronico AC,Campos Carneiro P,Alves VA,Zerbini MC,Liberman B,Carlos Gomes G,Kirschner MA

    更新日期:2000-02-15 00:00:00

  • Comparative evaluation of combined radiation-chlorambucil treatment of ovarian carcinomatosis.

    abstract::In a study conducted by the Eastern Cooperative Oncology Group, 51 evaluable women with advanced ovarian carcinoma were randomized to either abdominal radiation therapy alone, chlorambucil alone, or to a combination of radiation therapy and chlorambucil by members of the Eastern Cooperative Oncology Group. Provision w...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197511)36:5<1625::aid-cncr282036

    authors: Miller SP,Brenner S,Horton J,Stolbach L,Shnider BI,Pocock S

    更新日期:1975-11-01 00:00:00

  • Turcot's syndrome. Evidence for autosomal dominant inheritance.

    abstract::A case of Turcot's syndrome (colonic polyposis plus a malignant central nervous system tumor) occurring in a kindred with autosomal dominant colonic polyposis is presented. It is proposed that Turcot's syndrome patients can be classified into Type I where only siblings are affected and Type II where two or more genera...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830201)51:3<524::aid-cncr28205

    authors: Lewis JH,Ginsberg AL,Toomey KE

    更新日期:1983-02-01 00:00:00

  • Depression in patients with pancreatic carcinoma. Diagnostic and treatment issues.

    abstract:BACKGROUND:Cancer of the pancreas is a highly malignant illness with a very poor prognosis. Unfortunately, there has been little in the way of improvement in prognosis over the past 20 years. It is feared by patients because of its reputation as a deadly and often painful disease. Given these realities, it is not surpr...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0142(19960801)78:3<615::AID-CNC

    authors: Passik SD,Breitbart WS

    更新日期:1996-08-01 00:00:00

  • The validity of Pap smear parameters as predictors of endometrial pathology in menopausal women.

    abstract::Cytopathologists recognize that certain Pap smear findings are suspicious for endometrial pathology in menopausal women. To study their prognostic importance in the directed cervical smear, six parameters were used to evaluate smears for evidence of an endometrial lesion: the presence of (1) histiocytes, (2) multinucl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851101)56:9<2256::aid-cncr2820

    authors: Zucker PK,Kasdon EJ,Feldstein ML

    更新日期:1985-11-01 00:00:00

  • Association of asbestos and bronchogenic carcinoma in a population with low asbestos exposure.

    abstract::Quantitative counts of ferruginous bodies were performed on digests of lungs from 100 control and 30 lung cancer patients. It was found that the lung cancer group had significantly higher levels, although only 1 patient was known to be occupationally exposed to asbestos. It is suggested that even extremely low levels ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197504)35:4<1236::aid-cncr282035

    authors: Warnock ML,Churg AM

    更新日期:1975-04-01 00:00:00

  • The prognostic significance of nuclear DNA content in prostatic carcinoma.

    abstract::The prognostic significance of ploidy level was studied in prostatic carcinoma and compared with the prognostic significance of morphologic grade and clinical stage. A nonselected group of 145 patients was studied in whom prostatic carcinoma was diagnosed by fine-needle aspiration biopsy at the Karolinska Hospital in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920315)69:6<1432::aid-cncr2820

    authors: Forsslund G,Esposti PL,Nilsson B,Zetterberg A

    更新日期:1992-03-15 00:00:00

  • The natural history of breast carcinoma in the elderly: implications for screening and treatment.

    abstract:BACKGROUND:The authors evaluated the two indicators of metastatic proclivity (namely, virulence [V; the rate of appearance of distant metastases] and metastagenicity [M; the ultimate likelihood of developing distant metastases]) of breast carcinoma in elderly women. The authors then compared these characteristics with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20206

    authors: Singh R,Hellman S,Heimann R

    更新日期:2004-05-01 00:00:00

  • Prolonged survival with a longer duration of maintenance lenalidomide after autologous hematopoietic stem cell transplantation for multiple myeloma.

    abstract:BACKGROUND:Although lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto-HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known. METHODS:This study retrospectively analyzed all MM patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30366

    authors: Mian I,Milton DR,Shah N,Nieto Y,Popat UR,Kebriaei P,Parmar S,Oran B,Shah JJ,Manasanch EE,Orlowski RZ,Shpall EJ,Champlin RE,Qazilbash MH,Bashir Q

    更新日期:2016-12-15 00:00:00

  • Non-small cell lung cancer. Neuroresection of the solitary intracranial metastasis followed by radiochemotherapy.

    abstract::Fifteen selected patients with advanced intrathoracic non-small cell lung cancer and solitary metastasis were treated by a combined program including craniotomy, brain and chest irradiation, and systemic chemotherapy. One patient died because of cerebral hemorrhage after the operation. Five patients failed to achieve ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2569::aid-cncr282

    authors: Tummarello D,Porfiri E,Rychlicki F,Miseria S,Cellerino R

    更新日期:1985-12-01 00:00:00

  • C-erbB-2 oncogene protein in in situ and invasive lobular breast neoplasia.

    abstract::Lobular carcinoma in situ (LCIS) has uncertain malignant potential; biologic markers that will identify patients at risk for a poor clinical outcome have been sought actively. Amplification of the c-erbB-2 protooncogene has been correlated with poor prognosis in invasive mammary carcinoma, and immunohistochemical eval...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910715)68:2<331::aid-cncr28206

    authors: Porter PL,Garcia R,Moe R,Corwin DJ,Gown AM

    更新日期:1991-07-15 00:00:00

  • Relationship between androgen receptor binding activity in human prostate cancer and clinical response to endocrine therapy.

    abstract::The authors investigated the ability of androgen receptor binding in prostate cancer tissue to predict the response of prostate cancer patients to endocrine therapy. The clinical response of 37 previously untreated patients with various grades and stages of prostate cancer was correlated with androgen receptor binding...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870501)59:9<1599::aid-cncr2820

    authors: Benson RC Jr,Gorman PA,O'Brien PC,Holicky EL,Veneziale CM

    更新日期:1987-05-01 00:00:00

  • Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma.

    abstract:BACKGROUND:The sensitivity of the intraoperative diagnosis of sentinel lymph node (SLN) micrometastases and the metastases of invasive lobular carcinoma (ILC) is low. The goal of the current study was to assess whether the use of intraoperative, rapid immunohistochistochemistry (IHC) enhances the intraoperative detecti...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.21133

    authors: Leikola JP,Toivonen TS,Krogerus LA,von Smitten KA,Leidenius MH

    更新日期:2005-07-01 00:00:00