Mediterranean Kaposi's sarcoma in the elderly. A randomized study of oral etoposide versus vinblastine.

Abstract:

BACKGROUND:This Phase III trial was performed to compare the roles of oral etoposide and intravenous (i.v.) vinblastine in the treatment of Mediterranean Kaposi's Sarcoma (MEKS) in elderly patients with severe disease (Stages II, Ac/B, III, and IV). PATIENTS AND METHODS:Sixty-five patients were randomized to receive either oral etoposide (60 mg/m2 on Days 1-3 during the first course; 60 mg/m2 on Days 1-4 during the second course, and 60 mg/m2 on Days 1-4 during the second course, and 60 mg/m2 on Days 1-5 during the third course; the courses were recycled every 3 weeks) or an i.v. bolus of vinblastine (3 mg/m2 weekly for 3 weeks, and then 6 mg/m2 every 3 weeks). RESULTS:No significant difference between the two drugs was observed in terms of response rates (etoposide, 73.5% vs. vinblastine, 58%; P = 0.3), duration of response, or survival (median not yet reached at a median follow-up of 38 months). Side effects of both treatments were limited, although myelotoxicity was more evident in the vinblastine arm. CONCLUSIONS:Although it is feasible and well tolerated, the oral administration of etoposide at these doses and in this regimen does not appear superior to vinblastine in the treatment of MEKS. Further evaluation of a more intensive schedule in large cooperative clinical trials is needed to establish the role of this drug in comparison with reference treatments.

journal_name

Cancer

journal_title

Cancer

authors

Brambilla L,Labianca R,Boneschi V,Fossati S,Dallavalle G,Finzi AF,Luporini G

doi

10.1002/1097-0142(19941115)74:10<2873::aid-cncr282

subject

Has Abstract

pub_date

1994-11-15 00:00:00

pages

2873-8

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

74

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CANCER文献大全
  • The effect of Medicaid expansion among adults from low-income communities on stage at diagnosis in those with screening-amenable cancers.

    abstract:BACKGROUND:Several states have opted to expand Medicaid under the Patient Protection and Affordable Care Act (ACA), which offers insurance coverage to low-income individuals up to 138% of the federal poverty level. This expansion of Medicaid to a medically vulnerable population potentially can reduce cancer outcome dis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32895

    authors: Kim U,Koroukian S,Statler A,Rose J

    更新日期:2020-09-15 00:00:00

  • Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.

    abstract:BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.9032

    authors: Xu X,Sun TT,Gupta PK,Zhang P,Nasuti JF

    更新日期:2001-06-25 00:00:00

  • Prediction of intracranial metastases in cancer patients with headache.

    abstract:BACKGROUND:The current study was conducted to investigate the diagnostic value of neurologic evaluation for the prediction of intracranial metastases in cancer patients with new or changed headache. METHODS:Between February 1997 and February 2000, general practitioners and specialists referred cancer patients with new...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10379

    authors: Christiaans MH,Kelder JC,Arnoldus EP,Tijssen CC

    更新日期:2002-04-01 00:00:00

  • Relationship of 4F2 antigen with local growth and metastatic potential of squamous cell carcinoma of the larynx.

    abstract::The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-n...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901001)66:7<1493::aid-cncr2820

    authors: Esteban F,Ruiz-Cabello F,Concha A,Perez Ayala M,Delgado M,Garrido F

    更新日期:1990-10-01 00:00:00

  • Serum macrophage migration-inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer.

    abstract:BACKGROUND:This study aimed to determine the potential diagnostic value of migration-inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer. METHODS:A cohort of 97 patients with histologically confirmed gastric adenocarcinoma and 222 patients with d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24609

    authors: Xia HH,Yang Y,Chu KM,Gu Q,Zhang YY,He H,Wong WM,Leung SY,Yuen ST,Yuen MF,Chan AO,Wong BC

    更新日期:2009-12-01 00:00:00

  • Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

    abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820

    authors: Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JC

    更新日期:1992-05-01 00:00:00

  • Calcium channel blockers, cancer incidence, and cancer mortality in a cohort of U.S. women: the nurses' health study.

    abstract:BACKGROUND:Some studies have suggested that the use of calcium channel blockers may increase the risk of cancer. A possible association of the use of calcium channel blockers with cancer incidence and cancer mortality was addressed using data from the Nurses' Health Study. METHODS:In this study, a total of 18,635 fema...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Michels KB,Rosner BA,Walker AM,Stampfer MJ,Manson JE,Colditz GA,Hennekens CH,Willett WC

    更新日期:1998-11-01 00:00:00

  • Abridged republication of FIGO's staging classification for cancer of the ovary, fallopian tube, and peritoneum.

    abstract::Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorde...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29524

    authors: Prat J,FIGO Committee on Gynecologic Oncology.

    更新日期:2015-10-01 00:00:00

  • Non-Hodgkin's lymphoma in bone. Pathologic and radiologic features with clinical correlates.

    abstract::Thirty-seven lymphomas of bone were studied, including 33 diffuse large cell lymphomas, three undifferentiated (small noncleaved cell) lymphomas, and one well-differentiated (small) lymphocytic lymphoma. The large cell lymphomas were subclassified as large cleaved, large noncleaved, multilobated cell, and immunoblasti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871115)60:10<2494::aid-cncr282

    authors: Clayton F,Butler JJ,Ayala AG,Ro JY,Zornoza J

    更新日期:1987-11-15 00:00:00

  • Effects of tumor growth on interleukins and circulating immune complexes. Mechanisms of immune unresponsiveness.

    abstract::This study delineates the temporal relationship between immune complex formation and tumor growth, and provides one possible explanation for host immunosuppression during tumor growth. The authors have studied serial circulating immune complex (CIC) levels and interleukin (IL) elaboration by peripheral blood cells (IL...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840315)53:6<1373::aid-cncr2820

    authors: Ravikumar T,Steele G Jr,Rodrick M,Ross D,Wilson R,Lahey S,Wright D,Munroe A,King V

    更新日期:1984-03-15 00:00:00

  • Heterotransplantation of small cell lung carcinoma into nude mice. Stability of the phenotypic characters.

    abstract::In order to validate xenografted small cell lung carcinomas (SCLC) for biological studies, the authors established 12 lung neuroendocrine (NE) tumors (eight typical SCLC and four atypical NE tumors [ANE]) by heterotransplantation onto nude mice. Their characterization was performed using serial ultrastructural, enzyma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890915)64:6<1238::aid-cncr2820

    authors: Brambilla E,Jacrot M,Batandier C,Brichon PY,Morel F,Nagy-Mignotte H,Paramelle B,Brambilla C

    更新日期:1989-09-15 00:00:00

  • Establishment of three bleomycin-resistant human carcinoma cell lines and their cross-resistance to other antitumor agents.

    abstract::Three bleomycin-resistant (BLMr) human carcinoma cell lines (HeLa-BLMr, KB-BLMr, and Hepd-uvBLMr) were established in culture by progressively increasing the concentration of bleomycin (BLM). HeLa-BLMr and KB-BLMr were obtained after 5 and 2 months of incubation with BLM, whereas the establishment of Hepd-uvBLMr requi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880415)61:8<1501::aid-cncr2820

    authors: Urade M,Sugi M,Miyazaki T

    更新日期:1988-04-15 00:00:00

  • Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel.

    abstract:BACKGROUND:Radiation recall refers to a tissue reaction produced by a chemotherapeutic agent in a previously irradiated field that would not occur in a nonirradiated field. A number of agents have been reported to cause radiation recall. Recently, there have been case reports of recall dermatitis from paclitaxel treatm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950915)76:6<1069::aid-cncr2820

    authors: Schweitzer VG,Juillard GJ,Bajada CL,Parker RG

    更新日期:1995-09-15 00:00:00

  • Prolonged remissions in adults with acute leukemia following late intensification chemotherapy and immunotherapy.

    abstract::Sixty-two patients with acute leukemia who remained in continuous complete remission for 8 to 45 months received three courses of intensified therapy with new chemotherapeutic agents, after which they received no further chemotherapy. Immunotherapy with BCG was then administered to 55 of these patients. They have been...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810415)47:8<1937::aid-cncr2820

    authors: Bodey GP,Freireich EJ,McCredie KB,Smith TL,Gehan EA,Gutterman JU,Hersh EM

    更新日期:1981-04-15 00:00:00

  • The MAPK pathway across different malignancies: a new perspective.

    abstract::The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.28864

    authors: Burotto M,Chiou VL,Lee JM,Kohn EC

    更新日期:2014-11-15 00:00:00

  • High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas.

    abstract:BACKGROUND:To identify the factors that contribute to poorer colon carcinoma survival rates for African Americans compared with Caucasians, the authors evaluated survival differences based on the histologic grade (differentiation) of the tumor. METHODS:All 169 African Americans and 229 randomly selected non-Hispanic C...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21021

    authors: Alexander D,Jhala N,Chatla C,Steinhauer J,Funkhouser E,Coffey CS,Grizzle WE,Manne U

    更新日期:2005-05-15 00:00:00

  • Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis.

    abstract:BACKGROUND:None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esopha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980915)83:6<1074::aid-cn

    authors: Böttger TC,Youssef V,Dutkowski P,Maschek H,Brenner W,Junginger T

    更新日期:1998-09-15 00:00:00

  • Overexpression of podoplanin in oral cancer and its association with poor clinical outcome.

    abstract:BACKGROUND:Podoplanin is a mucin-like glycoprotein that is important in lymphangiogenesis but not blood vessel formation. Recent studies suggested a potential role of podoplanin in certain tumor cells. The purpose of the current study was to determine the role of podoplanin in head and neck squamous cell carcinoma (HNS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22061

    authors: Yuan P,Temam S,El-Naggar A,Zhou X,Liu DD,Lee JJ,Mao L

    更新日期:2006-08-01 00:00:00

  • Evaluation of direct medical costs of hospitalization for febrile neutropenia.

    abstract:BACKGROUND:Treatment of febrile neutropenia (FN) is costly, because it typically involves hospitalization. As cancer rates continue to increase, the number of patients suffering from FN will also increase, making it important to quantify the costs of treating this condition accurately and comprehensively. METHODS:A co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24773

    authors: Lathia N,Mittmann N,DeAngelis C,Knowles S,Cheung M,Piliotis E,Shear N,Walker S

    更新日期:2010-02-01 00:00:00

  • Poor prognosis associated with thrombocytosis in patients with cervical cancer.

    abstract::The medical records of 113 patients treated with radiation therapy for invasive cervical cancer between 1975 and 1985 were retrospectively reviewed. Patients with thrombocytosis (platelet count greater than 400,000/microliters) were compared with those with normal platelet counts. Thrombocytosis was present at the ini...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920615)69:12<2975::aid-cncr282

    authors: Hernandez E,Lavine M,Dunton CJ,Gracely E,Parker J

    更新日期:1992-06-15 00:00:00

  • Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis.

    abstract:BACKGROUND:It is believed that in the early stages of hepatocarcinogenesis, some adenomatous hyperplasias (AH) progress to early hepatocellular carcinoma (eHCC), and that many eHCC develop into overt hepatocellular carcinoma (HCC) through nodule-in-nodule formation. However, the proliferative activity of these small no...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940115)73:2<289::aid-cncr28207

    authors: Aoki K,Sakamoto M,Hirohashi S

    更新日期:1994-01-15 00:00:00

  • Effects of health insurance and race on breast carcinoma treatments and outcomes.

    abstract:BACKGROUND:The authors hypothesized that insurance payer and race would influence the care and outcomes for patients with breast carcinoma. METHODS:The authors examined treatments and adjusted risk of death (through 1997) for all incident cases of breast carcinoma occurring in Florida in 1994 (n = 11,113) by using sta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001201)89:11<2202::aid-cncr8>3

    authors: Roetzheim RG,Gonzalez EC,Ferrante JM,Pal N,Van Durme DJ,Krischer JP

    更新日期:2000-12-01 00:00:00

  • Natural killer cells in children with acute leukemia. The effect of interleukin-2.

    abstract::The purpose of this study was to determine (1) the number and activity of natural killer (NK) cells in children with acute leukemia at different stages of their disease; and (2) the effect of interleukin-2 (IL-2) in enhancing NK activity of these patients' cells. The mean percentage of Leu 11+ NK cells in patients at ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871215)60:12<2913::aid-cncr282

    authors: Mageed AA,Findley HW Jr,Franco C,Singhapakdi S,Alvarado C,Chan WC,Ragab AH

    更新日期:1987-12-15 00:00:00

  • Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?

    abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206

    authors: Eckardt VF,Giessler W,Kanzler G,Bernhard G

    更新日期:1992-01-15 00:00:00

  • Integration of human papillomavirus vaccination, cytology, and human papillomavirus testing.

    abstract::There is justifiable excitement about the recent introduction of prophylactic vaccines against human papillomavirus (HPV) types 16 (HPV-16) and HPV-18. Preventing these infections theoretically could avert approximately 70% of cervical cancer cases worldwide. In the U.S., numerous influential advocates are calling for...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22751

    authors: Schiffman M

    更新日期:2007-06-25 00:00:00

  • Prognostic variables in mycosis fungoides.

    abstract::The prognostic importance of various factors was analyzed for 347 patients registered by the Mycosis Fungoides Cooperative Group (MFCG). Extent of skin involvement at the time of registration and number of sites of clinically enlarged lymph nodes were clearly the most important prognostic variables, and were combined ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810601)47:11<2671::aid-cncr282

    authors: Green SB,Byar DP,Lamberg SI

    更新日期:1981-06-01 00:00:00

  • Ten-year change in neighborhood socioeconomic status and colorectal cancer.

    abstract:BACKGROUND:A growing body of research has demonstrated that individuals who live in neighborhoods with more severe socioeconomic deprivation may have higher risks for colorectal cancer (CRC). However, previous studies have examined neighborhood socioeconomic status (SES) at only 1 point in time, and it is unclear wheth...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31832

    authors: Zhang D,Matthews CE,Powell-Wiley TM,Xiao Q

    更新日期:2019-02-15 00:00:00

  • Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma.

    abstract::Solitary plasmacytoma of bone (SPB) and extramedullary plasmacytoma (EMPC) are unusual solitary tumors of plasma cell origin. The clinical differences between these tumors and multiple myeloma are the subject of continued study. This review examines the radiotherapy experience at M. D. Anderson Hospital. Between 1948 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197903)43:3<1007::aid-cncr282043

    authors: Corwin J,Lindberg RD

    更新日期:1979-03-01 00:00:00

  • Depression in patients with pancreatic carcinoma. Diagnostic and treatment issues.

    abstract:BACKGROUND:Cancer of the pancreas is a highly malignant illness with a very poor prognosis. Unfortunately, there has been little in the way of improvement in prognosis over the past 20 years. It is feared by patients because of its reputation as a deadly and often painful disease. Given these realities, it is not surpr...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0142(19960801)78:3<615::AID-CNC

    authors: Passik SD,Breitbart WS

    更新日期:1996-08-01 00:00:00

  • Prognostic value of p53 and MIB-1 in transitional cell carcinoma of the urinary bladder with regional lymph node involvement.

    abstract:BACKGROUND:The effect of p53 protein expression and MIB-1 proliferative activity on survival and chemotherapeutic response in patients with lymph node (LN)-positive transitional cell carcinoma (TCC) of the urinary bladder remains unclear. The objective of this study was to assess the ability of these markers to predict...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20567

    authors: Frank I,Cheville JC,Blute ML,Lohse CM,Karnes RJ,Weaver AL,Sebo TJ,Nehra A,Zincke H

    更新日期:2004-10-15 00:00:00