Comparative evaluation of combined radiation-chlorambucil treatment of ovarian carcinomatosis.

Abstract:

:In a study conducted by the Eastern Cooperative Oncology Group, 51 evaluable women with advanced ovarian carcinoma were randomized to either abdominal radiation therapy alone, chlorambucil alone, or to a combination of radiation therapy and chlorambucil by members of the Eastern Cooperative Oncology Group. Provision was made for crossover therapy for patients who were nonresponders to a single modality of treatment. Parameters followed included objective and subjective response rates and patient survival. The total response rate was 51%, with no significant difference among the three treatment regimens. Regarding survival, radiation therapy alone was significantly superior to the other regimens, with an average survival of 94.9 weeks. Best results were obtained in patients with normal performance status; for this group, radiation therapy alone offered the best chance for prolonged survival.

journal_name

Cancer

journal_title

Cancer

authors

Miller SP,Brenner S,Horton J,Stolbach L,Shnider BI,Pocock S

doi

10.1002/1097-0142(197511)36:5<1625::aid-cncr282036

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

1625-30

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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