The natural history of neoplastic development: the relation of experimental models to human cancer.

abstract：:A 17 year old man with a primary intracranial germ cell tumor in the pituitary region is reported. Both serum alpha-fetoprotein (AFP) and serum human chorionic gonadotropin (hCG) were found elevated preoperatively. Normal levels of serum AFP and hCG were found after operation and radiotherapy. By indirect immunofluore...

journal_title：Cancer

authors： Nørgaard-Pedersen B,Lindholm J,Albrechtsen R,Arends J,Diemer NH,Riishede J

更新日期：1978-06-01 00:00:00

abstract：:Apart from choriocarcinoma, involvement of the central nervous system (CNS) by gynecologic malignancy is rare. A 10-year retrospective review at the University of Washington Medical Center (Seattle, WA) and Swedish Hospital and Medical Center Tumor Registry (Seattle, WA) identified 14 patients with cerebral metastases...

journal_title：Cancer

authors： LeRoux PD,Berger MS,Elliott JP,Tamimi HK

更新日期：1991-04-15 00:00:00

abstract：BACKGROUND:Between 1980-1990, 126 patients were treated with radiation therapy (RT) and hyperthermia using 915-MHz external microwave applicators. All but 11 patients had failed to respond to previous therapy. METHODS:The mean tumor volume was 73 +/- 13 cm3, and the mean radiation dose delivered was 45 +/- 1 Gy. Hyper...

journal_title：Cancer

authors： Engin K,Leeper DB,Tupchong L,Waterman FM,Mansfield CM

更新日期：1993-07-01 00:00:00

abstract：:In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel ...

journal_title：Cancer

authors： Nomura S,Kanoh T

更新日期：1987-04-15 00:00:00

abstract：:Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...

journal_title：Cancer

authors： Recloux P,Weiser M,Piccart M,Sculier JP

更新日期：1988-05-01 00:00:00

abstract：:It was shown previously that invasive human transitional cell carcinoma cell line EJ, but not the noninvasive RT4 cells, can degrade basement membrane laminin and that the degradation of basement membrane laminin was a result of a redistribution of activated cysteine proteinase cathepsin B to the plasma membrane of th...

journal_title：Cancer

authors： Redwood SM,Liu BC,Weiss RE,Hodge DE,Droller MJ

更新日期：1992-03-01 00:00:00

abstract：:Fifty-nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty-eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12-1.97). In 90% of all tumors the DNA index w...

journal_title：Cancer

authors： Kouri M,Laasonen A,Mecklin JP,Järvinen H,Franssila K,Pyrhönen S

更新日期：1990-04-15 00:00:00

abstract：:At the Finsen Institute, Copenhagen, from 1971 to 1981, 134 patients were treated for lymph node metastases from primary cutaneous malignant melanoma of axial localization (e.g., in the head and neck and trunk), where metastases to regional lymph node groups were the first sign of dissemination. Due to the lack of suf...

journal_title：Cancer

authors： Lock-Andersen J,Partoft S,Jensen MG

更新日期：1988-11-01 00:00:00

abstract：:The effect of cis-diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse-grown human tumors following administration of single-agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and ...

journal_title：Cancer

authors： Kyriazis AP,Yagoda A,Kereiakes JG,Kyriazis AA,Whitmore WF Jr

更新日期：1983-08-01 00:00:00

abstract：:While using the natural killer (NK) cell-associated HNK-1 antibody in a panel of hematopoietic cell markers, the authors found that metastatic tumor cells in the bone marrow of a patient with disseminated prostatic carcinoma stained strongly with this antibody using an indirect immunofluorescence technique. More than ...

journal_title：Cancer

authors： Rusthoven JJ,Robinson JB,Kolin A,Pinkerton PH

更新日期：1985-07-15 00:00:00

abstract：BACKGROUND:An increase in resting energy expenditure (REE) is considered to contribute to the weight loss experienced by patients with cancer. However, alternations in basal metabolism vary among patients with different neoplasms. REE in patients with hepatocellular carcinoma (HCC), a common malignant tumor in Taiwan, ...

journal_title：Cancer

authors： Chen WJ,Chung YC

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

journal_title：Cancer

authors： Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Because carcinomas of unknown primary origin are highly malignant tumors with a bad prognosis (median survival, 6-12 months) and no current optimal therapy, the authors designed a prospective dose-dense chemotherapy regimen with the objective of improving the results observed in patients who receive conventi...

journal_title：Cancer

authors： Culine S,Fabbro M,Ychou M,Romieu G,Cupissol D,Pinguet F

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the esophagus is endemic in parts of South Africa. Previous case-control studies have shown many associations but no clear etiologic pathway has been established. METHODS:A case-control study of dietary and social factors was performed for 130 patient/control pairs matched for age...

journal_title：Cancer

authors： Sammon AM

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Flow cytometric analysis of trophoblastic tissue has shown that most partial hydatidiform moles (PMs) are triploid, whereas most complete moles (CMs) are diploid or tetraploid. Ploidy analysis can support a diagnosis of CM or PM. However, in some cases, a precise diagnosis cannot be rendered. METHODS:This s...

journal_title：Cancer

authors： Bocklage TJ,Smith HO,Bartow SA

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:hMLH1, the human MutL homologue, has been linked to microsatellite instability (MSI) in gastrointestinal tumors. However, to the authors' knowledge, the role of hMLH1, the other mismatch repair genes (MMR), and MSI in ovarian carcinoma has not been well defined. The purpose of the current study was to determ...

journal_title：Cancer

authors： Geisler JP,Goodheart MJ,Sood AK,Holmes RJ,Hatterman-Zogg MA,Buller RE

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...

journal_title：Cancer

authors： Elliott DD,Pitman MB,Bloom L,Faquin WC

更新日期：2006-04-25 00:00:00

abstract：BACKGROUND:Whether fatherhood status affects prostate cancer risk remains controversial. Recently, it was proposed that childless men are at lower prostate cancer risk than men with children and that men with sons may be at lower risk than men with daughters only. METHODS:National population-based register data were u...

journal_title：Cancer

authors： Jørgensen KT,Pedersen BV,Johansen C,Frisch M

更新日期：2008-02-15 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has...

journal_title：Cancer

authors： Daver N,McClain K,Allen CE,Parikh SA,Otrock Z,Rojas-Hernandez C,Blechacz B,Wang S,Minkov M,Jordan MB,La Rosée P,Kantarjian HM

更新日期：2017-09-01 00:00:00

abstract：:Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 microns/ml (normal less than 225 microns/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of e...

journal_title：Cancer

authors： Rotenberg Z,Weinberger I,Fuchs Y,Erdberg A,Davidson E,Agmon J

更新日期：1984-10-01 00:00:00

abstract：:Since 1981, 20 patients with anaplastic giant cell carcinoma of the thyroid have been prospectively treated according to a combination regimen of chemotherapy and external beam radiation therapy. Two types of chemotherapy were used every 4 weeks, depending on the patient's age. For those younger than 65 years, a combi...

journal_title：Cancer

authors： Schlumberger M,Parmentier C,Delisle MJ,Couette JE,Droz JP,Sarrazin D

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti-neuroectodermal antibodies in the absence of PND. Whether...

journal_title：Cancer

authors： Vural B,Chen LC,Saip P,Chen YT,Ustuner Z,Gonen M,Simpson AJ,Old LJ,Ozbek U,Gure AO

更新日期：2005-06-15 00:00:00

abstract：:Mesenchymal chondrosarcoma of bone and soft tissues treated at the Istituto Ortopedico Rizzoli are reviewed. The skeletal locations were prominent in five cases. Only two cases were in the soft tissues. Radiographic picture in the bone shows an aggressive osteolysis, with soft tissues invasion. Histologic picture is t...

journal_title：Cancer

authors： Bertoni F,Picci P,Bacchini P,Capanna R,Innao V,Bacci G,Campanacci M

更新日期：1983-08-01 00:00:00

abstract：:Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...

journal_title：Cancer

authors： Parfrey NA,Mann RB,Selonick SE,Beschorner WE

更新日期：1985-05-01 00:00:00

abstract：:A case of gastric plasmacytoma is reported in an 81-year-old woman. Immunofluorescent and immunoelectrophoretic studies showed that the tumor cells produced IgM-lambda molecules, whereas no monoclonal immunoglobulin could be detected both in the serum and in the urine. Of more than 60 reported cases of gastric plasmac...

journal_title：Cancer

authors： Funakoshi N,Kanoh T,Kobayashi Y,Miyake T,Uchino H,Ochi K

更新日期：1984-08-15 00:00:00

abstract：BACKGROUND:Patients with advanced soft tissue sarcomas (STS) have limited therapeutic options. Sorafenib (BAY 43-9006) is a multitargeted tyrosine kinase inhibitor of raf, vascular endothelial growth factor receptors 1 (VEGFR1) through 3, platelet-derived growth factor B, fms-like tyrosine kinase 3, and c-kit, and some...

journal_title：Cancer

authors： von Mehren M,Rankin C,Goldblum JR,Demetri GD,Bramwell V,Ryan CW,Borden E

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:During the last two decades, a rising incidence of adenocarcinoma of the esophagus has been observed in the Western world. The prognostic relevance of tumor-biological factors, such as DNA ploidy or c-erbB-2 overexpression, for overall survival following complete resection is still unknown. METHODS:In a ret...

journal_title：Cancer

authors： Nakamura T,Nekarda H,Hoelscher AH,Bollschweiler E,Harbeck N,Becker K,Siewert JR,Harbec N corrected to Harbeck N

更新日期：1994-04-01 00:00:00

abstract：:In a series of 25 patients with head and neck cancer who had severe pain, the type and cause of the pain were analyzed. There were two types of pain: nociceptive and non-nociceptive. Nineteen (76%) patients had nociceptive pain that could be subdivided into actual nociceptive pain (9 patients), nociceptive nerve pain ...

journal_title：Cancer

authors： Vecht CJ,Hoff AM,Kansen PJ,de Boer MF,Bosch DA

更新日期：1992-07-01 00:00:00

abstract：:With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...

journal_title：Cancer

authors： Robison LL

更新日期：1993-05-15 00:00:00

abstract：:Forty-milligram strips of malignant breast tissue were divided longitudinally into 20-mg microsamples. Soluble protein concentration was determined for one-half, and histologic evaluation for viable carcinoma content was made on its sister half. The correlation coefficient for 88 such comparisons was 0.330. This sugge...

journal_title：Cancer

authors： van Netten JP,Algard FT,Coy P,Carlyle SJ,Brigden ML,Thornton KR,To MP

更新日期：1982-06-01 00:00:00