Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas.

abstract：:The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...

journal_title：Cancer

authors： Ulbright TM,Stehman FB,Roth LM,Ehrlich CE,Ransburg RC

更新日期：1982-12-15 00:00:00

abstract：BACKGROUND:There are several well known but rare syndromes of inherited colonic cancer. Genetic epidemiologic studies also have demonstrated that relatives of individuals with colonic cancer in general exhibit an excess risk for this malignancy. METHODS:This report reviews the literature pertinent to genetic and famil...

journal_title：Cancer

authors： Burt RW,Bishop DT,Cannon-Albright L,Samowitz WS,Lee RL,DiSario JA,Skolnick MH

更新日期：1992-09-15 00:00:00

abstract：:Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Bot...

journal_title：Cancer

authors： Frey C,Twomey P,Keehn R,Elliott D,Higgins G

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Bortezomib is active in heavily pretreated multiple myeloma patients; the dose-limiting toxicity is peripheral neuropathy (PN). METHODS:The authors retrospectively reviewed the incidence, severity, and risk factors for PN in 78 patients who received bortezomib. The median age was 57 years (range, 33-80 year...

journal_title：Cancer

authors： Badros A,Goloubeva O,Dalal JS,Can I,Thompson J,Rapoport AP,Heyman M,Akpek G,Fenton RG

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RES...

journal_title：Cancer

authors： Hussain S,Anderson DN,Salvatti ME,Adamson B,McManus M,Braverman AS

更新日期：2000-05-15 00:00:00

abstract：:Clinicians can shed new light on the genetic and environmental origins of cancer, particularly multiple primary malignancies, by asking additional questions at the bedside. Areas to explore include occupational history, personal habits, residence, and medical and family histories with emphasis on subtle clues of disor...

journal_title：Cancer

authors： Mulvihill JJ,McKeen EA

更新日期：1977-10-01 00:00:00

abstract：:Historically coal mining populations have been reported to have elevated stomach cancer incidence rates. To identify which factors might be associated with cases who reside in these high risk areas, and specifically if particulate exposures from coal mining and coal utilization are associated with risk, a mining area ...

journal_title：Cancer

authors： Weinberg GB,Kuller LH,Stehr PA

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:A study was undertaken to identify new immunogenic human leukocyte antigen (HLA)-A 2402-restricted epitopes from human papillomavirus (HPV) type 16 E7 protein for immunotherapy against cervical cancer. METHODS:Synthetic overlapping peptides were screened by measuring the frequency of CD8(+) cytotoxic T lymp...

journal_title：Cancer

authors： Jang S,Kim YT,Chung HW,Lee KR,Lim JB,Lee K

更新日期：2012-04-15 00:00:00

abstract：BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...

journal_title：Cancer

authors： Yuan JM,Govindarajan S,Arakawa K,Yu MC

更新日期：2004-09-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a frequent complication of cancer and cancer treatment and is associated with multiple clinical consequences, including recurrent VTE, bleeding, and an increase in the risk of death. Although the risks associated with VTE have been well recognized in surgical cancer patients, there is a...

journal_title：Cancer

authors： Lyman GH

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...

journal_title：Cancer

authors： Gamelin EC,Danquechin-Dorval EM,Dumesnil YF,Maillart PJ,Goudier MJ,Burtin PC,Delva RG,Lortholary AH,Gesta PH,Larra FG

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Rising health care costs have caused providers to question the benefit of regular follow-up after treatment for patients with early stage cutaneous melanoma. The authors hypothesized that routine reassessment and careful education of these patients would facilitate earlier diagnosis of a subsequent second pr...

journal_title：Cancer

authors： DiFronzo LA,Wanek LA,Morton DL

更新日期：2001-04-15 00:00:00

abstract：:A 26-year-old man with erythroleukemia was found to have circulating micromegakaryocytes . Megakaryocytic features were defined by morphologic and cytochemical studies using light and electron microscopy with platelet-megakaryocyte peroxidase staining. This appears to be the first reported instance of erythroleukemia ...

journal_title：Cancer

authors： Yamauchi K,Miyauchi J,Nagao T

更新日期：1984-06-15 00:00:00

abstract：:Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 microns/ml (normal less than 225 microns/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of e...

journal_title：Cancer

authors： Rotenberg Z,Weinberger I,Fuchs Y,Erdberg A,Davidson E,Agmon J

更新日期：1984-10-01 00:00:00

abstract：:To determine whether the referral of lung cancer patients to university cancer centers was related to nonclinical factors, the medical charts were reviewed for almost all lung cancer patients diagnosed during the period of 1973-1976 in New Hampshire and Vermont. Greater distance from a cancer center, lower functional ...

journal_title：Cancer

authors： Greenberg ER,Dain B,Freeman D,Yates J,Korson R

更新日期：1988-10-15 00:00:00

abstract：BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...

journal_title：Cancer

authors： Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TC

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...

journal_title：Cancer

authors： Guise TA

更新日期：2000-06-15 00:00:00

abstract：:The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

journal_title：Cancer

authors： Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

更新日期：1986-07-15 00:00:00

abstract：:A familial cancer aggregation comprising sarcomas, brain tumors, leukemias, and carcinomas of breast, larynx, lung, adrenal, cortex, and other sites has been studied from a pathologic--genetic standpoint. Based upon sibships segregating for cancer, the genetic segregation parameter is estimated to be 45.6 +/- 11% whi...

journal_title：Cancer

authors： Lynch HT,Mulcahy GM,Harris RE,Guirgis HA,Lynch JF

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the...

journal_title：Cancer

authors： Koff JL,Li JX,Zhang X,Switchenko JM,Flowers CR,Waller EK

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Several pathologic staging systems for malignant pleural mesothelioma (MPM) have been published, but none of them provide optimal survival stratification or stage distribution among patients treated with surgery. Interpretation of prior studies that correlate pathologic factors with outcome has been confound...

journal_title：Cancer

authors： Richards WG,Godleski JJ,Yeap BY,Corson JM,Chirieac LR,Zellos L,Mujoomdar A,Jaklitsch MT,Bueno R,Sugarbaker DJ

更新日期：2010-03-15 00:00:00

abstract：:Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated wit...

journal_title：Cancer

authors： Takaue Y,Watanabe T,Hoshi Y,Abe T,Matsunaga K,Saito S,Hirao A,Kawano Y,Ninomiya T,Kuroda Y

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:The combination of paclitaxel with cisplatin or carboplatin has become the preferred chemotherapy regimen in the treatment of epithelial ovarian carcinoma. Anthracyclines also have activity in this disease. We conducted a Phase II study by using the combination of paclitaxel, cisplatin, and epirubicin for th...

journal_title：Cancer

authors： Papadimitriou CA,Moulopoulos LA,Vlahos G,Voulgaris Z,Kiosses E,Georgoulias N,Gika D,Diakomanolis E,Michalas S,Dimopoulos MA

更新日期：2000-10-01 00:00:00

abstract：:Between 1964 and 1982, 862 patients with acute leukemia who were collected from medical institutions throughout the country had a survival of 5 years or longer. Their remission has been achieved mainly with a combination therapy of vincristine and prednisone in childhood acute leukemia and daunomycin, cytosine arabino...

journal_title：Cancer

authors： Kawashima K,Nagura E,Yamada K,Hamajima N

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Women treated with tamoxifen for breast cancer are at increased risk of endometrial cancer. This study examines the experience at Roswell Park Cancer Institute (RPCI) with women diagnosed with both endometrial carcinoma (EC) and breast carcinoma (BC) to determine the risk and stage of endometrial carcinoma a...

journal_title：Cancer

authors： Cuenca RE,Giachino J,Arredondo MA,Hempling R,Edge SB

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS:Immunoreactivity of primary antibodies to the hu...

journal_title：Cancer

authors： Lee JJ,Hughes CS,Fine RL,Page RL

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The behavior of diffuse peritoneal mesotheliomas in women and the possible relation between tumor morphology and outcome are uncertain. Reported survival has ranged from < 1 month to > 14 years, and a previous study found that tumor morphology could not be used reliably for predicting outcome. The authors ex...

journal_title：Cancer

authors： Kerrigan SA,Turnnir RT,Clement PB,Young RH,Churg A

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:Fadrozole hydrochloride (CGS 16949A) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. Circulating estradiol, estrone, and estrone sulfate are reduc...

journal_title：Cancer

authors： Costa LA,Kopreski MS,Demers LM,Chinchilli VM,Santen RJ,Harvey HA,Lipton A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...

journal_title：Cancer

authors： Gong Z,Kristal AR,Schenk JM,Tangen CM,Goodman PJ,Thompson IM

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...

journal_title：Cancer

authors： Coppola D,Catalano E,Tang CK,Elfenbein IB,Harwick R,Mohr R

更新日期：1993-10-15 00:00:00