Discussion: genetics of multiple primary tumors: a clinical etiologic approach illustrated by three patients.

abstract：:From a total of 874 patients with small cell lung cancer (SCC), a series of 104 patients were reviewed to determine if bone marrow relapses are detectable by routine clinical investigations. Autopsy, including microscopical bone marrow examination, was performed in all the 104 patients and bone metastases were disclos...

journal_title：Cancer

authors： Kristjansen PE,Osterlind K,Hansen M

更新日期：1986-12-01 00:00:00

abstract：:One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...

journal_title：Cancer

authors： Eilber FR,Morton DL,Eckardt J,Grant T,Weisenburger T

更新日期：1984-06-15 00:00:00

abstract：BACKGROUND:Secondary acute myeloid leukemia (AML) after treatment with epipodophyllotoxins is being observed with increased frequency. Therapeutic options are limited for patients with secondary AML and the role of bone marrow transplantation is unclear. METHODS:The authors report the treatment outcome of a cohort of ...

journal_title：Cancer

authors： Sandler ES,Friedman DJ,Mustafa MM,Winick NJ,Bowman WP,Buchanan GR

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...

journal_title：Cancer

authors： Shirabe K,Shimada M,Kajiyama K,Gion T,Ikeda Y,Hasegawa H,Taguchi K,Takenaka K,Sugimachi K

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...

journal_title：Cancer

authors： Hussein MA,Wood L,Hsi E,Srkalovic G,Karam M,Elson P,Bukowski RM

更新日期：2002-11-15 00:00:00

abstract：BACKGROUND:Malignant peritoneal mesothelioma is a rare and fatal disease. Until recently, the treatment options were very limited and ineffective. The new comprehensive approach of cytoreductive surgery with perioperative intraperitoneal chemotherapy offers improved survival rates at a cost of considerable morbidity an...

journal_title：Cancer

authors： Yan TD,Haveric N,Carmignani CP,Chang D,Sugarbaker PH

更新日期：2005-02-15 00:00:00

abstract：:A primary fibrosarcoma of the thyroid occurring in a patient with a nodular goiter is described. Light microscopy showed interwoven bundles of spindle cells admixed with plump ovoid cells, and foci of multinucleated giant cells. Remnants of distorted thyroid follicles were found only at the periphery of the tumor. "Tr...

journal_title：Cancer

authors： Shin WY,Aftalion B,Hotchkiss E,Schenkman R,Berkman J

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Although aging is one of the most important risk factors for cancer, elderly patients tend to be excluded from cancer clinical trials, only on the basis of chronologic age. Performance Status (PS) has been used widely to select adult patients for entry into clinical trials, but it does not include a comprehe...

journal_title：Cancer

authors： Monfardini S,Ferrucci L,Fratino L,del Lungo I,Serraino D,Zagonel V

更新日期：1996-01-15 00:00:00

abstract：:In order to quantify the lymphocyte to epithelial cell ratio (L/E ratio of the thymoma, actual counting was performed. The L/E ratio was investigated in 25 specimens of 22 cases (22 initial tumors and 3 recurrent tumors). L/E ratios ranged from 0.27 to 4.10, and the mean value was 1.93 +/- 0.21. The mean L/E ratio of ...

journal_title：Cancer

authors： Masaoka A,Nagaoka Y,Maeda M,Monden Y,Seike Y

更新日期：1977-09-01 00:00:00

abstract：:Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...

journal_title：Cancer

authors： Schenker JG,Weinstein D,Okon E

更新日期：1979-11-01 00:00:00

abstract：:The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...

journal_title：Cancer

authors： Li CK

更新日期：1982-11-15 00:00:00

abstract：BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...

journal_title：Cancer

authors： Brandes AA,Amistà P,Gardiman M,Volpin L,Danieli D,Guglielmi B,Carollo C,Pinna G,Turazzi S,Monfardini S

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The majority of patients with astrocytomas of the cerebellum have an excellent prognosis; however, a small percentage of patients continue to do poorly. To clarify the clinical, pathologic, and treatment characteristics that determine prognosis and therapeutic recommendations, a large group of patients with ...

journal_title：Cancer

authors： Hayostek CJ,Shaw EG,Scheithauer B,O'Fallon JR,Weiland TL,Schomberg PJ,Kelly PJ,Hu TC

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:To the authors' knowledge, the potential prognostic value of DNA ploidy in vulvar melanoma has not been evaluated in previous series. METHODS:Clinical data and follow-up information were retrieved from the hospital records of 75 patients treated from 1956 to 1987. Histopathologic specimens were reviewed for...

journal_title：Cancer

authors： Scheistrøen M,Tropé C,Koern J,Pettersen EO,Abeler VM,Kristensen GB

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND METHODS:The antiemetic activity of ondansetron (Zofran, Glaxo Pharmaceuticals, Research Triangle Park, NC) was evaluated in 25 patients with recurrent melanoma who were treated sequentially with dacarbazine (DTIC), vinblastine, and cisplatin. The antiemetic regimen included ondansetron alone in 11 patien...

journal_title：Cancer

authors： Legha SS,Hodges C,Ring S

更新日期：1992-10-01 00:00:00

abstract：:Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of ac...

journal_title：Cancer

authors： Kramer JH,Norman D,Brant-Zawadzki M,Ablin A,Moore IM

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:The measurement of estrogen receptors (ER) in breast cancer specimens has traditionally been assessed with a dextran-coated charcoal assay (DCCA). More recently the immunohistochemical staining (IHC) method has gained increasing popularity because of its ability to use fixed tissue, assess needle biopsies, a...

journal_title：Cancer

authors： Alberts SR,Ingle JN,Roche PR,Cha SS,Wold LE,Farr GH Jr,Krook JE,Wieand HS

更新日期：1996-08-15 00:00:00

abstract：:The morphologic features, phenotype, and functions of OKM1+ leukemic T-cells were studied. The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic character...

journal_title：Cancer

authors： Tagawa S,Taniguchi N,Tokumine Y,Tamaki T,Konishi I,Kanayama Y,Inoue R,Machii T,Kitani T

更新日期：1986-04-15 00:00:00

abstract：BACKGROUND:Knowledge of the expression of the galectins in human colon carcinomas is mainly restricted to galectin-3 and, to a lesser extent, galectin-1. The current study analyzed the prognostic values contributed by galectin-1, galectin-3, galectin-4, and galectin-8 in cases of colon carcinoma. METHODS:The authors s...

journal_title：Cancer

authors： Nagy N,Legendre H,Engels O,André S,Kaltner H,Wasano K,Zick Y,Pector JC,Decaestecker C,Gabius HJ,Salmon I,Kiss R

更新日期：2003-04-15 00:00:00

abstract：:Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

journal_title：Cancer

authors： Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

更新日期：1980-09-15 00:00:00

abstract：BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...

journal_title：Cancer

authors： Gapstur SM,Dupuis J,Gann P,Collila S,Winchester DP

更新日期：1996-04-15 00:00:00

abstract：:The ultrastructure of three cases of osteoblastoma is described. The osteoblasts resemble normal osteoblasts with a few exceptions: irregular, indented nuclei, and occasional mitochondria with curved cristae and electron-lucent areas. The osteocytes and osteoclasts basically resemble their normal counterparts. There a...

journal_title：Cancer

authors： Steiner GC

更新日期：1977-05-01 00:00:00

abstract：:Seventeen cases of malignant melanoma of soft parts (clear cell sarcoma) are reported. The patients ranged from 9 to 70 years of age, but 13 were between 10 and 40 years of age. There were eight male patients and nine female patients. The most common tumor location (seven patients) was the foot, followed by the area a...

journal_title：Cancer

authors： Sara AS,Evans HL,Benjamin RS

更新日期：1990-01-15 00:00:00

abstract：:POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...

journal_title：Cancer

authors： Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

更新日期：1992-06-01 00:00:00

abstract：:The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" ...

journal_title：Cancer

authors： Lehane DE,Watson S,Lane M

更新日期：1975-05-01 00:00:00

abstract：:The prognostic significance of objectively measured karyometric variables (ploidy pattern, nuclear roundness, area, elongation, chromatin texture, and nearest nucleus distance) was investigated in relation to clinical (stage and type of disease) and morphologic (histologic patterns) variables in 27 patients with the d...

journal_title：Cancer

authors： Galera-Davidson H,González-Cámpora R,Mora-Marín JA,Matilla-Vincente A,Dytch HE,Bartels PH,Lerma-Puertas E,Andrada-Becerra E,Bibbo M

更新日期：1990-05-15 00:00:00

abstract：BACKGROUND:Radiotherapy (RT) plays a major role in the management of hemangiopericytomas (HAP). The present analysis evaluates the role of precision RT in the management of HAP of the central nervous system (CNS) and represents one of the largest series of HAP treated with RT that can be found in the literature. METHO...

journal_title：Cancer

authors： Combs SE,Thilmann C,Debus J,Schulz-Ertner D

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...

journal_title：Cancer

authors： Schiff D,Suman VJ,Yang P,Rocca WA,O'Neill BP

更新日期：1998-03-01 00:00:00

abstract：:Many clinicians use group support to reduce the psychosocial difficulties of persons with cancer. This study compared the long-term benefits of a thematic counseling model used both as a structure for group support and for counseling patients individually. The thematic model included eight counseling sessions focused ...

journal_title：Cancer

authors： Cain EN,Kohorn EI,Quinlan DM,Latimer K,Schwartz PE

更新日期：1986-01-01 00:00:00

abstract：:To assess the value in Ewing's sarcoma of a new multiagent therapy (vincristine, cyclophosphamide, Adriamycin, (doxorubicin) procarbazine), 30 children with a localized tumor (eight distal, nine proximal, 13 central lesions) treated at the Institut Gustave-Roussy between 1973 and 1976 (E3), were pair-matched by site o...

journal_title：Cancer

authors： Zucker JM,Henry-Amar M,Sarrazin D,Blache R,Patte C,Schweisguth O

更新日期：1983-08-01 00:00:00