Malignant melanoma of the vulva. Evaluation of prognostic factors with emphasis on DNA ploidy in 75 patients.

Abstract:

BACKGROUND:To the authors' knowledge, the potential prognostic value of DNA ploidy in vulvar melanoma has not been evaluated in previous series. METHODS:Clinical data and follow-up information were retrieved from the hospital records of 75 patients treated from 1956 to 1987. Histopathologic specimens were reviewed for histologic type, depth of invasion, vessel invasion, and ulceration. Flow cytometric DNA measurements were performed on paraffin embedded samples. RESULTS:Forty-three patients had International Federation of Gynecology and Obstetrics Stage I disease, 14 Stage II, 8 Stage III and 10 Stage IV. Sixty-five patients were treated by surgery, six by radiotherapy, and four patients with advanced disease received no therapy. The surgical procedure was local excision in 17 patients, vulvectomy in 22, and radical vulvectomy with inguinal lymph node dissection in 26. Five- and 10-year corrected survival rates were 46% and 37%, respectively. Recurrences were seen in 43 (66%) of the patients treated by surgery. Independent prognostic factors for corrected survival in the entire group of 75 patients were inguinal lymph node metastases (P = 0.016), angioinvasion (P = 0.027), tumor localization to clitoris, and multifocal tumors (P = 0.043). For the 65 patients treated by surgery, independent prognostic factors for disease free survival were angioinvasion (P < 0.001), age at diagnosis (P = 0.003), DNA ploidy (P = 0.004), and ulceration (P = 0.027). The independent prognostic factors for long term survival were tumor localization to clitoris (P = 0.018), DNA ploidy (P = 0.045), and inguinal lymph node involvement (P = 0.053). Radical surgery did not improve disease free or long term survival. CONCLUSIONS:DNA ploidy is an independent factor that predicts prognosis in patients with vulvar melanoma, and should be considered together with previously known factors. Radical surgery does not improve prognosis and is not recommended when the inguinal lymph nodes are clinically negative.

journal_name

Cancer

journal_title

Cancer

authors

Scheistrøen M,Tropé C,Koern J,Pettersen EO,Abeler VM,Kristensen GB

doi

10.1002/1097-0142(19950101)75:1<72::aid-cncr282075

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

72-80

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

75

pub_type

杂志文章

相关文献

CANCER文献大全
  • A novel arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma after vascular supply distribution via superselective embolization.

    abstract:BACKGROUND:Patients with American Joint Committee on Cancer Stage IV advanced pancreatic carcinoma have been treated by systemic chemotherapy, intraarterial chemotherapy, radiation therapy, and multidisciplinary treatment using a combination of these. However, the outcome has not always been satisfactory. In the curren...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Homma H,Doi T,Mezawa S,Takada K,Kukitsu T,Oku T,Akiyama T,Kusakabe T,Miyanishi K,Niitsu Y

    更新日期:2000-07-15 00:00:00

  • Impact of the posttransplant lymphoproliferative disorder subtype on survival.

    abstract:BACKGROUND:Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31339

    authors: Koff JL,Li JX,Zhang X,Switchenko JM,Flowers CR,Waller EK

    更新日期:2018-06-01 00:00:00

  • Infections in patients with aplastic anemia: experience at a tertiary care cancer center.

    abstract:BACKGROUND:Infection is a significant cause of death in patients with aplastic anemia (AA). However, few recent studies have examined infectious complications in patients with AA. METHODS:The authors retrospectively evaluated the type of infections, associated pathogens, and outcome of infectious episodes (IEs) in pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11478

    authors: Torres HA,Bodey GP,Rolston KV,Kantarjian HM,Raad II,Kontoyiannis DP

    更新日期:2003-07-01 00:00:00

  • The Save our Sisters Project. A social network strategy for reaching rural black women.

    abstract::Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target pop...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1071::aid-cncr282

    authors: Eng E

    更新日期:1993-08-01 00:00:00

  • Bleomycin-induced pulmonary fibrosis mimicking recurrent metastatic disease in a patient with testicular carcinoma: case report of the CT scan appearance.

    abstract::Pulmonary fibrosis is a well-recognized complication of bleomycin therapy. Detection of bleomycin-induced pulmonary fibrosis by computed axial tomographic scanning (CT) has not been reported. We report on a patient in whom the development of lesions on chest CT scan following cessation of chemotherapy (including bleom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810115)47:2<236::aid-cncr28204

    authors: Nachman JB,Baum ES,White H,Cruissi FG

    更新日期:1981-01-15 00:00:00

  • Loss of heterozygosity and genomic instability in synchronous endometrioid tumors of the ovary and endometrium.

    abstract:BACKGROUND:The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950815)76:4<650::aid-cncr28207

    authors: Shenson DL,Gallion HH,Powell DE,Pieretti M

    更新日期:1995-08-15 00:00:00

  • Ovarian epithelial tumors of borderline malignancy. A clinical and pathologic study of 109 cases.

    abstract::One hundred nine cases of ovarian tumors of low malignant potential (borderline tumors) diagnosed at Stanford University Medical Center from 1958 to 1982 were reviewed. The patients ranged in age from 10 to 79 years (mean, 40.5 years). The histologic types and corresponding stages of these neoplasms were 73 serous (St...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861101)58:9<2052::aid-cncr2820

    authors: Bostwick DG,Tazelaar HD,Ballon SC,Hendrickson MR,Kempson RL

    更新日期:1986-11-01 00:00:00

  • EphA2 overexpression is associated with angiogenesis in ovarian cancer.

    abstract:BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22415

    authors: Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK

    更新日期:2007-01-15 00:00:00

  • Characterization of six cell lines established from human pancreatic adenocarcinomas.

    abstract:BACKGROUND:Six human pancreatic carcinoma cell lines, designated as KMP-1 to KMP-6, were established and maintained in vitro for > 3 years. All were derived from pancreatic ductal adenocarcinomas. The six cell lines originated from either primary pancreatic tumors, metastatic liver tumors, or metastases to lymph nodes....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990215)85:4<832::aid-cnc

    authors: Kato M,Shimada Y,Tanaka H,Hosotani R,Ohshio G,Ishizaki K,Imamura M

    更新日期:1999-02-15 00:00:00

  • Influence of patients' preferences and treatment site on cancer patients' end-of-life care.

    abstract:BACKGROUND:Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending therapy was associated with their EOL care. METHODS:Coping with Cancer is a multisite, prospect...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.25217

    authors: Wright AA,Mack JW,Kritek PA,Balboni TA,Massaro AF,Matulonis UA,Block SD,Prigerson HG

    更新日期:2010-10-01 00:00:00

  • Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma.

    abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10899

    authors: Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

    更新日期:2002-11-01 00:00:00

  • Phase I clinical trial and pharmacokinetics of carboplatin (NSC 241240) by single monthly 30-minute infusion.

    abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860115)57:2<222::aid-cncr28205

    authors: Koeller JM,Trump DL,Tutsch KD,Earhart RH,Davis TE,Tormey DC

    更新日期:1986-01-15 00:00:00

  • Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.

    abstract:BACKGROUND:The carboplatin-based chemotherapeutic regimen M-CAVI (methotrexate, carboplatin, and vinblastine) is active against bladder carcinoma and can be administered to patients who are ineligible to receive cisplatin or doxorubicin. The authors designed a randomized study to evaluate whether M-CAVI offers a therap...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1097-0142(19971115)80:10<1966::aid-c

    authors: Bellmunt J,Ribas A,Eres N,Albanell J,Almanza C,Bermejo B,Solé LA,Baselga J

    更新日期:1997-11-15 00:00:00

  • Breast biopsy patterns and outcomes in Surveillance, Epidemiology, and End Results-Medicare data.

    abstract:BACKGROUND:Despite known benefits to needle biopsy for suspicious breast lesions, variability in the use of this technique has been documented in practice. We sought to study the use of needle biopsy and open surgical biopsy in women with breast cancer, predictors of needle biopsy use, and the effect of biopsy choice o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24085

    authors: Friese CR,Neville BA,Edge SB,Hassett MJ,Earle CC

    更新日期:2009-02-15 00:00:00

  • Primary seminoma of the mediastinum. Cancer Control Agency of British Columbia experience.

    abstract::Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fract...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850115)55:2<450::aid-cncr28205

    authors: Lee YM,Jackson SM

    更新日期:1985-01-15 00:00:00

  • CT-guided percutaneous microwave ablation of adrenal malignant carcinoma: preliminary results.

    abstract:BACKGROUND:Microwave ablation has recently been developed as a safe and effective treatment for a variety of tumors. The authors evaluated the safety and efficacy of computed tomography (CT)-guided percutaneous microwave ablation of adrenal malignant tumors. METHODS:Nine patients between 41 and 83 years of age (averag...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26128

    authors: Li X,Fan W,Zhang L,Zhao M,Huang Z,Li W,Gu Y,Gao F,Huang J,Li C,Zhang F,Wu P

    更新日期:2011-11-15 00:00:00

  • Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

    abstract:BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26409

    authors: Cassier PA,Gelderblom H,Stacchiotti S,Thomas D,Maki RG,Kroep JR,van der Graaf WT,Italiano A,Seddon B,Dômont J,Bompas E,Wagner AJ,Blay JY

    更新日期:2012-03-15 00:00:00

  • PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression.

    abstract:BACKGROUND:PD-L1 (programmed death ligand 1, B7-H1) is a cell surface glycoprotein that can impair T-cell function. PD-L1 is aberrantly expressed by multiple human malignancies and has been shown to carry a highly unfavorable prognosis in patients with kidney cancer. The role of PD-L1 was evaluated as a mechanism for l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22588

    authors: Inman BA,Sebo TJ,Frigola X,Dong H,Bergstralh EJ,Frank I,Fradet Y,Lacombe L,Kwon ED

    更新日期:2007-04-15 00:00:00

  • Adriamycin, BCNU plus cyclophosphamide (ABC) in advanced carcinoma of the head and neck.

    abstract::Forty-four patients with advanced carcinoma of the head and neck were treated with cyclophosphamide, 400 mg/m2 plus BCNU, 100 mg/m2 day 1 followed by adriamycin 40 mg/m2 day 2, with therapy repeated every 4 weeks. Of 31 evaluable patients, there were 1 complete response, and 10 partial responses (35%). Four of 8 patie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197911)44:5<1571::aid-cncr282044

    authors: Presant CA,Ratkin G,Klahr C,Brown C

    更新日期:1979-11-01 00:00:00

  • Ovarian dysplasia: nuclear texture analysis.

    abstract:BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931201)72:11<3253::aid-cncr282

    authors: Deligdisch L,Miranda C,Barba J,Gil J

    更新日期:1993-12-01 00:00:00

  • Induction of apoptosis and suppression of clonogenicity of ovarian carcinoma cells with estrogen mustard.

    abstract:BACKGROUND:This study was conducted to evaluate whether estramustine (estrogen mustard [EM]) is a promising alternative in the treatment of patients with epithelial ovarian carcinoma (OVCA). EM is a microtubule-associated protein (MAP) specific antimicrotubule agent with low toxicity. METHODS:The authors investigated ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990615)85:12<2616::aid-c

    authors: Chen Z,Fadiel A,Jia JF,Sakamoto H,Carbone R,Naftolin F

    更新日期:1999-06-15 00:00:00

  • Conservative treatment versus mastectomy in breast cancer tumors with macroscopic diameter of 20 millimeters or less. The experience of the Institut Gustave-Roussy.

    abstract::A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19840301)53:5<1209::aid-cncr2820

    authors: Sarrazin D,Lê M,Rouëssé J,Contesso G,Petit JY,Lacour J,Viguier J,Hill C

    更新日期:1984-03-01 00:00:00

  • Leukemic iritis with hypopyon.

    abstract::A patient with acute lymphoblastic leukemia who had received CNS sanctuary treatment with cranial X-irradiation and intrathecal methotrexate displayed his first sign of relapse as iritis with malignant hypopyon. Treatment included topical and subconjunctival corticosteroids and local X-irradiation. Leukemic infiltrati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197910)44:4<1511::aid-cncr282044

    authors: Gruenewald RL,Perry MC,Henry PH

    更新日期:1979-10-01 00:00:00

  • Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT. METHODS:Between March 1995 and December 2003, 59 patients dia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21043

    authors: Kim DY,Park W,Lim DH,Lee JH,Yoo BC,Paik SW,Kho KC,Kim TH,Ahn YC,Huh SJ

    更新日期:2005-06-01 00:00:00

  • Prolonged venous infusion of cisplatin and concurrent radiation therapy for lung carcinoma. A feasibility study.

    abstract::Fifty patients with non resectable and/or inoperable bronchogenic carcinoma were entered into a feasibility study of cisplatin (CDDP) given in continuous infusion with concurrent radiation therapy. The radiation therapy regimen consisted of 2 Gy given 5 days a week in the first 3 and last 2 weeks of a 7-week split cou...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910115)67:2<357::aid-cncr28206

    authors: Bedini AV,Tavecchio L,Milani F,Gramaglia A,Spreafico C,Marchianò A,Ravasi G

    更新日期:1991-01-15 00:00:00

  • Skeletal muscle wasting and protein-energy malnutrition in children with a newly diagnosed acute leukemia.

    abstract::The changes in skeletal muscle mass of 14 children with newly diagnosed acute leukemia were studied during the first 24 weeks of antileukemia therapy. A muscle index was calculated from the femoral quadriceps muscle thickness, measured by using an ultrasound method, and from the body surface area. Serum albumin concen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900715)66:2<373::aid-cncr28206

    authors: Koskelo EK,Saarinen UM,Siimes MA

    更新日期:1990-07-15 00:00:00

  • The first score predicting overall survival in patients with metastatic spinal cord compression.

    abstract:BACKGROUND:The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC). METHODS:Based on a multivariate survival analysis of 1852 patients who were treated with radiotherapy (RT) for MSCC, a scoring system was developed. The system incl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23150

    authors: Rades D,Dunst J,Schild SE

    更新日期:2008-01-01 00:00:00

  • Disappearance of the predictive value of prognostic variables in childhood acute lymphoblastic leukemia: a report from Childrens Cancer Study Group.

    abstract::The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810715)48:2<370::aid-cncr28204

    authors: Sather H,Coccia P,Nesbit M,Level C,Hammond D

    更新日期:1981-07-15 00:00:00

  • Variation in colorectal cancer incidence in the United States by subsite of origin.

    abstract:BACKGROUND:Colorectal cancer incidence rates vary widely internationally, by race and gender, and have changed over time. Investigation of the patterns by subsite within the colorectum may suggest clues of possible etiologic significance for further study. METHODS:Using population-based data on more than 120,000 cases...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<3819::aid-cncr282

    authors: Devesa SS,Chow WH

    更新日期:1993-06-15 00:00:00

  • Treatment of malignant melanoma with dacarbazin (DTIC-DOME) with special reference to urinary excretion of 5-S-cysteinyldopa.

    abstract::Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800115)45:2<245::aid-cncr28204

    authors: Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman H

    更新日期:1980-01-15 00:00:00