Abstract:
BACKGROUND:Colorectal cancer incidence rates vary widely internationally, by race and gender, and have changed over time. Investigation of the patterns by subsite within the colorectum may suggest clues of possible etiologic significance for further study. METHODS:Using population-based data on more than 120,000 cases diagnosed 1976-1987 in the United States Surveillance, Epidemiology, and End Results program, colorectal cancer incidence was evaluated by subsite of origin. RESULTS:Little racial variation was evident for cecum and ascending colon cancers; rates were higher among blacks than whites for transverse and descending colon cancers but lower for sigmoid, rectosigmoid, and rectal cancers. Rates generally increased over time for most colon sites, especially sigmoid colon among white men, but declined slightly for rectal cancer among whites. The sex ratio increased among whites monotonically from 1.12 for cecum to 1.71 for rectal cancers. The distal colon cancer excess among men was most notable at older ages, contrasting with slightly higher rates among women at younger ages. Geographic differences were particularly notable for transverse and rectosigmoid colon cancers. CONCLUSIONS:It may be fruitful for future studies to evaluate factors affecting colorectal carcinogenesis by subsite of origin.
journal_name
Cancerjournal_title
Cancerauthors
Devesa SS,Chow WHdoi
10.1002/1097-0142(19930615)71:12<3819::aid-cncr282subject
Has Abstractpub_date
1993-06-15 00:00:00pages
3819-26issue
12eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24792
更新日期:2010-02-15 00:00:00
abstract:BACKGROUND:The presence of single-nucleotide polymorphisms (SNPs) within the 3'-untranslated regions of genes could affect the binding between a microRNA (miRNA) and its target, with consequences on gene expression regulation. Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that thes...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27435
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas of the hand and foot present unique management challenges. The purpose of the current study study was to determine oncologic outcome, particularly with respect to factors affecting local recurrence, distant recurrence, and disease-specific survival. METHODS:A retrospective study was per...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10750
更新日期:2002-08-15 00:00:00
abstract::In contrast with the expectations of the authors and with reports suggesting a decline in risk for scrotal cancer, Connecticut Tumor Registry data neither showed detectable decrease in risk over the 45-year-period for all 95 scrotal malignancies nor for the 71 epithelial cancers. The age distribution of scrotal cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<596::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Patients with chronic lymphocytic leukemia (CLL) that transforms to Richter syndrome (RS) frequently show atypical lymphocytes in bone marrow; however, a diagnosis of RS requires confirmation of the presence of sheets of large cells in bone marrow or lymph nodes. METHODS:In this study, the authors evaluated...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20251
更新日期:2004-05-15 00:00:00
abstract::Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197808)42:2<570::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract::A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1911::aid-cncr282
更新日期:1983-05-15 00:00:00
abstract::The authors report on five patients with secondary leukemia (SL) and one of the "specific" chromosomal rearrangements usually encountered in de novo acute nonlymphoblastic leukemia: inv(16), t(15;17), t(8;21), and t(9;11). They were characterized by solid tumor as the primary malignancy in four of five cases, absence ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2505::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract:BACKGROUND:Recent advances in the early detection of prostatic adenocarcinoma have stimulated interest in the development of techniques for determining metastatic potential. METHODS:One hundred cases of adenocarcinoma, including 66 biopsy and radical prostatectomy specimens; 20 biopsies alone; and 14 transurethral res...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931115)72:10<3020::aid-cncr282
更新日期:1993-11-15 00:00:00
abstract:BACKGROUND:The polyamine system is a promising target for anticancer therapy. Ideally, an antineoplastic compound affecting this system should inhibit both ornithine decarboxylase and the polyamine transporter, and toxicity should be mild. Agmatine, decarboxylated L-arginine, appears to be such a compound. METHODS:Ade...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20407
更新日期:2004-08-15 00:00:00
abstract::Three-hundred whole thyroid glands were collected at autopsy from patients who had no known clinical history of thyroid disease, and who varied from 13 to 82 years of age; 200 were male and 100 female. Thyroid glands were weighed, measured, and examined after previous formalin fixation. Histologic examination was done...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19891101)64:9<1888::aid-cncr2820
更新日期:1989-11-01 00:00:00
abstract::A retrospective analysis was performed on all patients with pituitary adenomas treated at the Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, Missouri. Of 210 patients treated from April 1954 through December 1982, 70 were treated with radiotherapy alone (RT), 121 received immediate postoper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890401)63:7<1308::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:This article reviews the salient pathologic and clinical features of 171 patients with Stage III-IV disease who were 60 years of age or older who were treated on four Hodgkin disease (HD) protocols from 1969 to 1988. METHODS:Pretherapy sections were reviewed centrally for correlation of the histologic class...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930301)71:5<1857::aid-cncr2820
更新日期:1993-03-01 00:00:00
abstract::A 1.95-kg fetus delivered at 33 weeks' gestational age survived less than 1 hour. Physical examination and autopsy disclosed an enormous, protuberant primary malignant melanoma of the skin, enveloping most of the back. A rim of surrounding hyperpigmented skin proved to be a giant congenital melanocytic nevus (GCMN), f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1371::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800801)46:3<452::aid-cncr28204
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:In recent years numerous reports have discussed the relationship between the human leukocyte antigen and lung cancer. However, the genetic background of lung cancer has not yet been precisely clarified. METHODS:To investigate the genetic background of lung cancer, the human leukocyte antigens in 159 normal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940215)73:4<1184::aid-cncr2820
更新日期:1994-02-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long-term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26203
更新日期:2011-12-15 00:00:00
abstract:BACKGROUND:Nearly 50% of urothelial carcinoma patients with lymph node-negative invasive cancers recur after radical surgery. In many cases, occult local or lymph node disease may be present but undetectable by current approaches. Reverse-transcriptase polymerase chain reaction (RT-PCR)-detectable mRNA of Uroplakin II ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.21953
更新日期:2006-07-01 00:00:00
abstract::A case-referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty-five male STS patients were thereby compared with 220 living and 110 dead population-based refe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<652::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract::The potential role of paraneoplastic Cushing's syndrome (CS) was assessed on the clinical course of patients with small cell lung cancer. A retrospective comparison was done of complications and survival rates according to the presence or absence of CS in patients with small cell lung cancer who died within 90 days of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<66::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:In a previous clinical trial, the authors disclosed that the expression of tumor cell motility factor gp78hAMFR correlates with tumor progression in patients with bladder carcinoma. This study was initiated to evaluate whether the combination of cytostatic drugs with an antimotility factor has an effect on c...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19970801)80:3<465::aid-cnc
更新日期:1997-08-01 00:00:00
abstract::The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was measured under saturating substrate (5-FU) and cosubstrate concentrati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<1903::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::Six hundred fifty-eight cases of previously untreated non-Hodgkin's lymphoma seen between 1970 and 1979 at the Medical Department, the Finsen Institute, were the basis for a comparative study of the prognostic value of the Rappaport, Kiel, and Lukes & Collins classifications and the new translation system, the Working...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850515)55:10<2442::aid-cncr282
更新日期:1985-05-15 00:00:00
abstract:BACKGROUND:Recent studies have shown that multiple cytokines are secreted by ovarian epithelial cancer cells. Previous studies have shown that the cancer cell lines secrete macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 (IL-1), interleukin-6 (IL-6)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931015)72:8<2433::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract:BACKGROUND:Long-term survivors of testicular cancer (TC) who received cisplatin-based chemotherapy have an increased risk of cardiovascular disease. A cross-sectional study was performed to objectively assess cardiovascular risk, subclinical atherosclerosis, and endothelial function in long-term survivors of TC. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23389
更新日期:2008-05-01 00:00:00
abstract::To remove regionally recurrent cancer of the rectum completely, more radical extensive resections were attempted than the conventional ones in 35 patients. Twenty-two patients underwent total pelvic exenteration. In 23, sacral resection was done, combined with other procedures including excision of the entire circumfe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920615)69:12<2876::aid-cncr282
更新日期:1992-06-15 00:00:00
abstract::The cytologic, histologic and ultrastructural features of a malignant carcinomatous mesothelioma of the tunica vaginalis testis in a 30-year old patient are described. This is the first such case with preoperative diagnosis by cytologic examination of hydrocele fluid and the second with documented history of exposure ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<119::aid-cncr28204
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Radiotherapy (RT) has been a risk factor for development of soft tissue sarcomas (STS). The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24462
更新日期:2009-09-15 00:00:00