Intestinal tumor and agmatine (decarboxylated arginine): low content in colon carcinoma tissue specimens and inhibitory effect on tumor cell proliferation in vitro.

abstract：BACKGROUND:The availability of Ki-67 monoclonal antibody has opened new possibilities for an extensive analysis of cell kinetics in human neoplasms. Ki-67 antibody reveals a nuclear antigen that is expressed in proliferating but not in quiescent cells. Although the reliability of Ki-67 immunostaining has been evaluated...

journal_title：Cancer

authors： Scotlandi K,Serra M,Manara MC,Maurici D,Benini S,Nini G,Campanacci M,Baldini N

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The prognostic relevance of activated oncogenes and oncoproteins has not been well studied in papillary thyroid cancer, which is slow-growing, with only regional spread in most cases. Therefore, the influence of some protein markers and tumor cell proliferation on disease progress in a series of patients wit...

journal_title：Cancer

authors： Akslen LA,Varhaug JE

更新日期：1995-11-01 00:00:00

abstract：:Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma consti...

journal_title：Cancer

authors： Yoneda K

更新日期：1990-01-01 00:00:00

abstract：:A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...

journal_title：Cancer

authors： Tepper J,Nardi G,Sutt H

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esopha...

journal_title：Cancer

authors： Böttger TC,Youssef V,Dutkowski P,Maschek H,Brenner W,Junginger T

更新日期：1998-09-15 00:00:00

abstract：:A 49-year-old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry,...

journal_title：Cancer

authors： Law IP,Koch FJ,Cannon GB,Herberman RB,Oldham RK

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...

journal_title：Cancer

authors： Nakamura S,Yao T,Aoyagi K,Iida M,Fujishima M,Tsuneyoshi M

更新日期：1997-01-01 00:00:00

abstract：:Forty patients with disseminated malignant melanoma were treated with triple combination chemotherapy consisting of Imidazole Carboxamide, BCNU and Vincristine. Seventeen of 40 patients (42.5%) showed significant responses including three complete responses. Responses were seen in cutaneous, lymph node and pulmonary m...

journal_title：Cancer

authors： Cohen SM,Greenspan EM,Ratner LH,Weiner MJ

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine whether standardized treatment of germ cell tumors (GCTs) could overcome sociodemographic factors limiting patient care. METHODS:The records of all patients undergoing primary treatment for GCTs at both a public safety net hospital and an academic tertiary care c...

journal_title：Cancer

authors： Chertack N,Ghandour RA,Singla N,Freifeld Y,Hutchinson RC,Courtney K,Bowman IA,Arafat W,Meng X,Moore JA,Aydin AM,Sagalowsky AI,Margulis V,Lotan Y,Woldu SL,Bagrodia A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Despite advances in first-line therapy, there are few data on treatment of glioblastoma multiforme (GBM) at recurrence. Temozolomide (TMZ) is well tolerated and may have activity despite prior TMZ exposure if novel dose schedules are used. METHODS:The authors reviewed their experience with a continuous TMZ ...

journal_title：Cancer

authors： Perry JR,Rizek P,Cashman R,Morrison M,Morrison T

更新日期：2008-10-15 00:00:00

abstract：:Paraneoplastic nervous system syndromes are being identified with increasing frequency because of greater physician awareness and the availability of serodiagnostic tests for some syndromes. Frequently, paraneoplastic syndromes develop in the setting of an indolent, limited stage, or otherwise occult malignancy. As a ...

journal_title：Cancer

authors： Glantz MJ,Biran H,Myers ME,Gockerman JP,Friedberg MH

更新日期：1994-01-01 00:00:00

abstract：:Despite proven benefits of neoadjuvant chemotherapy in patients with locally advanced, invasive breast cancer, no regimen is recommended as the treatment of choice. Neoadjuvant chemotherapy regimens encompass single-agent and combination therapy and sequential treatment. For this report, the author reviewed the litera...

journal_title：Cancer

authors： Buzdar AU

更新日期：2007-12-01 00:00:00

abstract：:For 52 patients with depressed adenomas of the stomach, histopathologic studies were done on 56 tumors and for 43 of them, histochemical and immunohistochemical features were examined. In addition, nondepressed adenomas (n = 57) and the depressed type of early gastric adenocarcinomas of the well-differentiated variety...

journal_title：Cancer

authors： Xuan ZX,Ambe K,Enjoji M

更新日期：1991-05-01 00:00:00

abstract：:Twenty-four patients who developed extramedullary disease during the course of Philadelphia chromosome-positive chronic myelogenous leukemia are described. The most frequent sites of extramedullary disease were lymph nodes (54%), bone (37%), and skin and soft tissue (29%). The appearance of extramedullary disease was ...

journal_title：Cancer

authors： Terjanian T,Kantarjian H,Keating M,Talpaz M,McCredie K,Freireich EJ

更新日期：1987-01-15 00:00:00

abstract：BACKGROUND:The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in the epidemiology of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). METHODS:Cancer registry data from 1988-2000 were linked with AIDS registry data...

journal_title：Cancer

authors： Diamond C,Taylor TH,Aboumrad T,Anton-Culver H

更新日期：2006-01-01 00:00:00

abstract：:Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...

journal_title：Cancer

authors： Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

更新日期：1987-11-15 00:00:00

abstract：:Fourteen patients with 16 metastatic ostogenic sarcoma lesions were treated with high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR), adriamycin, and pulse high-dose cyclophosphamide combined with radiation therapy. Thirteen of 16 lesions responded. Responses consisted of relief of pain (6/6 patients) i...

journal_title：Cancer

authors： Rosen G,Tefft M,Martinez A,Cham W,Murphy ML

更新日期：1975-03-01 00:00:00

abstract：:From 1954 through 1982, 57 patients with invasive, distal rectal cancer had a full-thickness local excision with curative intent. Prognostic criteria and need for further treatment were based on the histopathologic results of the operative specimen. The overall 5-year survival rate was 83.4%. The rectal cancer-specifi...

journal_title：Cancer

authors： DeCosse JJ,Wong RJ,Quan SH,Friedman NB,Sternberg SS

更新日期：1989-01-15 00:00:00

abstract：BACKGROUND:Deletion or loss of heterozygosity (LOH) at the polymorphic loci on the short arm of chromosome 3 has been reported in a large number of renal cell, small cell lung, non-small cell lung, and cervical carcinomas, suggesting the presence of one or more putative tumor suppressor genes at chromosome 3p. Similar ...

journal_title：Cancer

authors： el-Naggar AK,Lee MS,Wang G,Luna MA,Goepfert H,Batsakis JG

更新日期：1993-08-01 00:00:00

abstract：:The exact nature of the association between hormones and the development of breast cancer remains uncertain. Studies of endogenous hormone levels and breast cancer suggest a possible role of estrogens and androgens in the cause of breast cancer. Numerous studies have been conducted to assess the risk of breast cancer ...

journal_title：Cancer

authors： Helzlsouer KJ,Couzi R

更新日期：1995-11-15 00:00:00

abstract：:Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

journal_title：Cancer

authors： Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

更新日期：1985-06-15 00:00:00

abstract：:Studies of chemotherapy in advanced or recurrent gynecologic cancer have focussed on ovarian, cervical, and endometrial carcinoma. For celomic epithelial carcinomas of the ovary, a large number of cytotoxic agents have been shown to be active. Dramatic improvement in frequency of response with lesser improvement in su...

journal_title：Cancer

authors： Thigpen T,Vance R,Lambuth B,Balducci L,Khansur T,Blessing J,McGehee R

更新日期：1987-10-15 00:00:00

abstract：:Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...

journal_title：Cancer

authors： Steensma DP,Brunner AM,DeZern AE,Garcia-Manero G,Komrokji RS,Odenike OS,Roboz GJ,Savona MR,Stone RM,Sekeres MA

更新日期：2018-12-15 00:00:00

abstract：:Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...

journal_title：Cancer

authors： McDermott DF

更新日期：2009-05-15 00:00:00

abstract：:From November 1985 to August 1988, the National Study Group for Oesophageal Cancer collected and centralized data on 1926 new cases of oesophageal cancer in South Africa. A standard data sheet was used to record the age, sex, and condition of the patients, the site, length, and circumferential extent of the tumor, the...

journal_title：Cancer

authors： Mannell A,Murray W

更新日期：1989-12-15 00:00:00

abstract：BACKGROUND:Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize; however, to the authors' knowledge there are limited data regarding the spread of disease through cerebrospinal fluid (CSF). METHODS:Eight of 200 consecutive patients (4%) with meningiomas...

journal_title：Cancer

authors： Chamberlain MC,Glantz MJ

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to i...

journal_title：Cancer

authors： Kim JH,Yoon HK,Sung KB,Ko GY,Gwon DI,Shin JH,Song HY

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) are a specific clinicopathologic entity characterized by activating mutations in the c-KIT gene. These mutations are associated with increased immunohistochemical staining for the c-KIT protein. Because many GISTs display a definitive response to the KIT inhibitor imat...

journal_title：Cancer

authors： Willmore-Payne C,Layfield LJ,Holden JA

更新日期：2005-06-25 00:00:00

abstract：:The clinical, patient-oriented focus of medicine and psychology is contrasted with the epidemiologic (public health) approach in assessing the role of life-style factors and health promotion in cancer research. The unifying host-agent-environment epidemiologic paradigm is applied to contemporary cancer prevention issu...

journal_title：Cancer

authors： Celentano DD

更新日期：1991-02-01 00:00:00

abstract：:Clinical, histological and ultrastructural features of three small cell carcinomas arising in the parotid gland are presented. The light microscopic appearance of two of the neoplasms suggested neuroendocrine cell derivation, confirmed by electron microscopy in both instances. The fine structure of the third neoplasm ...

journal_title：Cancer

authors： Kraemer BB,Mackay B,Batsakis JG

更新日期：1983-12-01 00:00:00