Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis.

Abstract:

BACKGROUND:None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esophagus. METHODS:Specimens from 41 patients with adenocarcinoma of Barrett's esophagus who underwent esophageal resection were embedded in paraffin and studied immunohistochemically to determine the expression of CD44 splice variants. Histomorphologic parameters and survival time were not known at the time of the investigation. RESULTS:Correlations between favorable clinical or histomorphologic parameters and CD44s or any of the split variants could not be established. Down-regulation of CD44s and the split variant v10 was significantly correlated with pT classification. Furthermore, down-regulation of CD44v10 and up-regulation of CD44v7 were significantly correlated with ploidy. There was a significant correlation between CD44s and split variants in tumorous and nontumorous tissue from the same patient. Down-regulation of CD44s and CD44v4 had a significant influence on prognosis in that it was associated with shortened life expectancy. Multivariate analysis revealed that the expression of CD44v4 was an independent factor in prognosis. CONCLUSIONS:The results obtained for this small patient sample suggest that CD44v4 is a new independent prognostic parameter for adenocarcinoma of Barrett's esophagus that can be determined preoperatively by biopsy. It may therefore be helpful in planning therapy by allowing the identification of patients who may benefit from esophageal resection as well as those who are at high risk for morbidity and mortality even when the tumor is otherwise resectable. Further studies of larger patient samples are required to validate the results of the current study.

journal_name

Cancer

journal_title

Cancer

authors

Böttger TC,Youssef V,Dutkowski P,Maschek H,Brenner W,Junginger T

doi

10.1002/(sici)1097-0142(19980915)83:6<1074::aid-cn

subject

Has Abstract

pub_date

1998-09-15 00:00:00

pages

1074-80

issue

6

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19980915)83:6<1074::AID-CN

journal_volume

83

pub_type

杂志文章

相关文献

CANCER文献大全
  • Systemic aspergillosis as cause of myocardial infarction.

    abstract::Systemic aspergillosis is encountered with increasing prevalence in immunocompromised patients undergoing chemotherapy. The current communication describes the clinical and postmortem findings in three leukemic patients who developed myocardial infarction secondary to Aspergillus embolization of the coronary arteries....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861101)58:9<2146::aid-cncr2820

    authors: Andersson BS,Luna MA,McCredie KB

    更新日期:1986-11-01 00:00:00

  • Chemotherapy of malignant thymoma. Case report and review of the literature.

    abstract::The authors report the case of a patient with malignant thymoma unresponsive to combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP] and cisplatin/VP-16) who subsequently achieved clinical response to continuous daily prednisone. A review of the literature indicates that predniso...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860315)57:6<1101::aid-cncr2820

    authors: Hu E,Levine J

    更新日期:1986-03-15 00:00:00

  • Are prognostic factors for local control of breast cancer treated by primary radiotherapy significant for patients treated by mastectomy?

    abstract::Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820

    authors: Rosen PP,Kinne DW,Lesser M,Hellman S

    更新日期:1986-04-01 00:00:00

  • Use of carcinoembryonic antigen in small cell lung cancer. Prognostic value and relation to the clinical course 1.

    abstract::Carcinoembryonic antigen (CEA) was measured in 147 patients at diagnosis of small cell lung cancer; 17% of patients with limited disease and 51% with extensive disease had an abnormal CEA level (greater than 10 ng/ml). The median level was higher in extensive than in limited disease (11 ng/ml and 5.8 ng/ml, respective...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2047::aid-cncr282

    authors: Laberge F,Fritsche HA,Umsawasdi T,Carr DT,Welch S,Murphy WK,Chiuten DF,Dhingra HM,Farha P,Spitzer G

    更新日期:1987-06-15 00:00:00

  • A morphometric study of neovascularization in colorectal carcinoma.

    abstract:BACKGROUND:Neovascularization reportedly is correlated with metastasis, recurrence, and prognosis in some types of tumors. Microvessel quantification in so-called "hot spots" has been studied extensively as the only factor reflecting angiogenesis in various malignant tumors. The objective of this report was to evaluate...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Pavlopoulos PM,Konstantinidou AE,Agapitos E,Kavantzas N,Nikolopoulou P,Davaris P

    更新日期:1998-11-15 00:00:00

  • Monocytic leukemia in infancy. A review of eight children.

    abstract::The clinical and pathologic features of eight infants with monocytic leukemia are reviewed. The children were all aged 12 months or less at diagnosis and had a high incidence of extramedullary features, skin infiltration being particularly common. The diagnosis was established by conventional morphologic and cytochemi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851001)56:7<1584::aid-cncr2820

    authors: Darbyshire PJ,Smith JH,Oakhill A,Mott MG

    更新日期:1985-10-01 00:00:00

  • Adult acute leukemia. Aggressive treatment improves survival.

    abstract::Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830615)51:12+<2460::aid-cncr28

    authors: Eyre HJ,Ward JH,Priebat DA

    更新日期:1983-06-15 00:00:00

  • Lymphoma of the thyroid. An unusual clinical course in a patient possessing a 14/21 translocation.

    abstract::The unusual course of a lymphoma in a woman with a chromosome abnormality is reported. When aged 30 years, the right lobe of her thyroid gland was found to be infiltrated by a follicular lymphoma. Two years later, poorly differentiated diffuse lymphoctic lymphoma recurred locally, grew rapidly, and infiltrated the adj...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<259::aid-cncr2820380

    authors: Langlands AO,MacLean N

    更新日期:1976-07-01 00:00:00

  • Ovarian dysplasia: nuclear texture analysis.

    abstract:BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931201)72:11<3253::aid-cncr282

    authors: Deligdisch L,Miranda C,Barba J,Gil J

    更新日期:1993-12-01 00:00:00

  • Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999.

    abstract:BACKGROUND:Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23866

    authors: Linabery AM,Ross JA

    更新日期:2008-11-01 00:00:00

  • Ectopic hormone production by endocrine tumors: localization of hormones at the cellular level by immunocytochemistry.

    abstract::Clinical and laboratory data, histologic, electron microscopic and immunocytochemical findings of the tumors of eight patients suffering from Cushing's syndrome and of one patient with hypercalcemia are described. The unlabeled antibody enzyme method was used for the detection of insulin, glucagon, somatostatin, pancr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811101)48:9<2029::aid-cncr2820

    authors: Heitz PU,Klöppel G,Polak JM,Staub JJ

    更新日期:1981-11-01 00:00:00

  • Comparison of tumor pathology with duration of survival of North American patients with hepatocellular carcinoma.

    abstract:BACKGROUND:Several of the large studies addressing prognosis and survival from hepatocellular carcinoma (HCC) have been from Europe and Asia, but only a few have emanated from North America. Survival statistics from other parts of the world may not be applicable to the North American population because of etiologic, de...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950815)76:4<579::aid-cncr28207

    authors: Nzeako UC,Goodman ZD,Ishak KG

    更新日期:1995-08-15 00:00:00

  • Therapy-related leukemia: a panmyelosis.

    abstract::Fifteen patients developed acute nonlymphocytic leukemia (ANLL) 31 to 182 months following chemotherapy and/or radiotherapy for various malignancies and one non-neoplastic disorder. The ANLL was commonly heralded by a brief preleukemic phase consisting of cytopenias and a variety of morphologic abnormalities. At diagn...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1285::aid-cncr282043

    authors: Foucar K,McKenna RW,Bloomfield CD,Bowers TK,Brunning RD

    更新日期:1979-04-01 00:00:00

  • Do hormones cause breast cancer?

    abstract::The evidence that various endogenous and exogenous sex hormones play a role in the etiology of breast cancer is reviewed. It is hypothesized that prolonged exposure to normal levels of ovarian estrogens and cyclic progesterone resulting from early menarche and late menopause, and primarily willful nulliparity and late...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19840201)53:3+<595::aid-cncr2820

    authors: Thomas DB

    更新日期:1984-02-01 00:00:00

  • Cancer prevention through health promotion. Defining the role of physicians in public health.

    abstract::In recent years a major focus in the delivery of cancer prevention services has been on the actions of physicians in ambulatory care practice. Whereas delivery of these services has increased markedly, it is likely that physician actions overall are not producing expected measurable benefits to whole populations. The ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940815)74:4+<1418::aid-cncr282

    authors: Love RR

    更新日期:1994-08-15 00:00:00

  • Racial disparities in urologist visits among elderly men with prostate cancer: a cohort analysis of patient-related and county of residence-related factors.

    abstract:BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28894

    authors: Onukwugha E,Osteen P,Jayasekera J,Mullins CD,Mair CA,Hussain A

    更新日期:2014-11-01 00:00:00

  • The coexistence of lymphangiosarcoma and Kaposi's sarcoma in a renal transplant recipient.

    abstract::A case of coexisting lymphangiosarcoma and Kaposi's sarcoma that occurred in a female renal transplant recipient is presented. Both sarcomas were localized to the skin and were slowly progressive over several years. The coexistence of these two sarcomas may indicate that they arose from a common precursor endothelial ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911115)68:10<2330::aid-cncr282

    authors: Studniberg HM,Rivers JK,Cooke BE,Barnetson RS

    更新日期:1991-11-15 00:00:00

  • Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50.

    abstract:BACKGROUND:We previously reported that a single prostate-specific antigen (PSA) measured at ages 44-50 was highly predictive of subsequent prostate cancer diagnosis in an unscreened population. Here we report an additional 7 years of follow-up. This provides replication using an independent data set and allows estimate...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25568

    authors: Lilja H,Cronin AM,Dahlin A,Manjer J,Nilsson PM,Eastham JA,Bjartell AS,Scardino PT,Ulmert D,Vickers AJ

    更新日期:2011-03-15 00:00:00

  • Expression of carbohydrate antigens in human pulmonary adenocarcinoma.

    abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820

    authors: Kawai T,Suzuki M,Kase K,Ozeki Y

    更新日期:1993-09-01 00:00:00

  • After treatment. Psychosocial issues in gynecologic cancer survivorship.

    abstract::The woman treated for gynecologic cancer must contend with a challenging group of issues in her efforts to recover psychologically in the months and years after treatment: chance of dying, changed self-perception, treatment-related menopause, impaired or lost fertility, sexual dysfunction, and relationship problems mu...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19951115)76:10+<2117::aid-cncr28

    authors: Auchincloss SS

    更新日期:1995-11-15 00:00:00

  • Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas.

    abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207

    authors: Uehara H,Nakaizumi A,Iishi H,Tatsuta M,Kitamra T,Okuda S,Ohigashi H,Ishikawa O,Takenaka A,Ishiguro S

    更新日期:1994-08-01 00:00:00

  • Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers.

    abstract::Aryl hydrocarbon hydroxylase (AHH) inducibility was determined in a lymphoblast test system in 2,000 consecutive middle-aged male smokers, 304 ex-smokers, and 218 never-smokers in the same birth-year cohorts. Intraindividual, intraobserver, and interobserver, as well as temporal, reproducibility was checked in a speci...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851015)56:8<1988::aid-cncr2820

    authors: Trell L,Korsgaard R,Janzon L,Trell E

    更新日期:1985-10-15 00:00:00

  • The spectrum of cytologic features in nonproliferative breast lesions.

    abstract:BACKGROUND:The reliability of cytologic criteria to classify nonproliferative breast lesions (NPBL) is still debated. Sampling error and heterogeneity of breast lesions complicates the histologic correlation of fine-needle aspiration results further. METHODS:To provide optimal cytohistologic correlation, two smears (o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.9020

    authors: Sidawy MK,Tabbara SO,Bryan JA,Poprocky LA,Frost AR

    更新日期:2001-04-25 00:00:00

  • A multicenter phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi's sarcoma.

    abstract:BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acqu...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.11009

    authors: Bernstein ZP,Chanan-Khan A,Miller KC,Northfelt DW,Lopez-Berestein G,Gill PS

    更新日期:2002-12-15 00:00:00

  • Clinical research update: zoledronate.

    abstract::The prolonged administration of bisphosphonates can reduce the frequency of morbid skeletal events in patients with metastatic breast carcinoma or multiple myeloma. The development of more potent bisphosphonates will simplify current therapeutic schemes and could improve the therapeutic effectiveness of bisphosphonate...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19971015)80:8+<1699::aid-c

    authors: Body JJ

    更新日期:1997-10-15 00:00:00

  • Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis.

    abstract::The kinetics of initial arrest in organs, distribution, survival, and fate of 125I-iododeoxyuridine-labeled B16 melanoma tumor cells injected intravenously into normal, tumor-sensitized and immune manipulated syngeneic and allogeneic mice were investigated. Groups of animals were killed at intervals ranging from two m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197707)40:1<46::aid-cncr28204001

    authors: Fidler IJ,Gersten DM,Riggs CW

    更新日期:1977-07-01 00:00:00

  • Malignant inflammatory histiocytoma (inflammatory fibrous histiocytoma): report of a patient with four lesions.

    abstract::A patient with four subcutaneous inflammatory fibrous histiocytomas is presented. Three of these tumors developed synchronously. The neoplasms were examined by light and electron microscopy and were composed of well differentiated histiocytes, multinucleated histiocytes, and less differentiated cells. The ultrastructu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800101)45:1<179::aid-cncr28204

    authors: Miller R,Kreutner A Jr,Kurtz SM

    更新日期:1980-01-01 00:00:00

  • Simultaneous gastric cancer in monozygotic twins.

    abstract::Monozygotic twins developed gastric cancers that were found almost simultaneously. A 47-year-old man complained of nausea and vomiting; an upper gastrointestinal series and endoscopy revealed advanced gastric cancer invading the serosa. Palliative subtotal gastrectomy was performed. In his asymptomatic twin a gastric ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19881201)62:11<2430::aid-cncr282

    authors: Matsukura N,Onda M,Tokunaga A,Yoshiyuki T,Shimizu Y,Nishi K,Furukawa K,Yoshiyasu M,Kiyama T,Tanaka N

    更新日期:1988-12-01 00:00:00

  • The National Cancer Data Base report on cancer in Hispanics. Relationships between ethnicity, poverty, and the diagnosis of some cancers.

    abstract:BACKGROUND:Previous Commission on Cancer studies have examined time trends in stage of disease, treatment patterns, and survival for special populations. Reported herein are the most current National Cancer Data Base data for Hispanics. METHODS:Two Calls for Data have yielded a total of 23,650 cancer reports for Hispa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941015)74:8<2386::aid-cncr2820

    authors: Villar HV,Menck HR

    更新日期:1994-10-15 00:00:00

  • Acute pancreatitis associated with continuous infusion cytarabine therapy: a case report.

    abstract:BACKGROUND:While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported to the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-C

    authors: McBride CE,Yavorski RT,Moses FM,Robson ME,Solimando DA Jr,Byrd JC

    更新日期:1996-06-15 00:00:00