Abstract:
BACKGROUND:While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported to the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complicated by comorbid illnesses and the coadministration of other drugs associated with acute pancreatitis. METHODS:This report describes the clinical course of a patient with acute myelogenous leukemia (AML) who developed recurrent pancreatitis associated with cytarabine therapy. RESULTS:A male age 36 years with French-American-British M5B acute myelogenous leukemia received induction cytarabine (200 mg/m2/day) by continuous infusion for 7 days, and subsequently developed acute pancreatitis. The patient was rechallenged with intermittent, bolus, high dose cytarabine (HDAC) (3 g/m2bid administered over 3 hours) during the following intensification treatment, but did not develop clinical acute pancreatitis. Retreatment with continuous infusion cytarabine at a later time resulted in recurrence of acute pancreatitis. CONCLUSIONS:This case illustrates that cytarabine treatment may cause acute pancreatitis, and that this toxicity may be schedule dependent. In those with known sensitivity to cytarabine, altering the administration technique may avoid this complication.
journal_name
Cancerjournal_title
Cancerauthors
McBride CE,Yavorski RT,Moses FM,Robson ME,Solimando DA Jr,Byrd JCdoi
10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-Csubject
Has Abstractpub_date
1996-06-15 00:00:00pages
2588-91issue
12eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-Cjournal_volume
77pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11799
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The presence of urinary excretion products of human chorionic gonadotropin (hCG) has been proposed as a tumor marker. To ascertain the clinical value in gynecologic cancers, the authors studied 612 nonpregnant women. METHODS:Three different assays in four clinical groups were compared: no disease, benign di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4124::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:PC-SPES is an herbal supplement whose mechanisms of action are poorly understood, but may be estrogenic. The objective of the current report is to describe the effects of discontinuing PC-SPES treatment in four patients with androgen-independent prostate carcinoma. METHODS:Patient charts were retrospectivel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10269
更新日期:2002-02-01 00:00:00
abstract::A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<619::aid-cncr28205
更新日期:1983-08-15 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) with portal venous invasion (PVI) has a very poor prognosis, with a median survival of 3 months and virtually no survival at 1 year. The combination of intraarterial 5-fluorouracil (FU) and systemic interferon-alpha (IFNalpha) was recently reported to be effective against HCC w...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.21832
更新日期:2006-05-01 00:00:00
abstract::Only three previous reports on the ultrastructural appearance of tibial adamantinoma have been found among some 120 cases of this tumor reported in the literature. The tumor in our case is less differentiated than the cases previously reported. We believe it is of epithelial character and the possibilities of its hist...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197709)40:3<1138::aid-cncr282040
更新日期:1977-09-01 00:00:00
abstract::Tobacco use in the US is currently responsible for more than 30% of all cancer deaths, including cancers of the lung, larynx, oral cavity, pharynx, pancreas, kidney, bladder, and cervix. The lung cancer epidemic in men and then women since the turn of the century followed an increased prevalence of cigarette smoking. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881015)62:1+<1702::aid-cncr282
更新日期:1988-10-15 00:00:00
abstract:BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32392
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28261
更新日期:2013-10-15 00:00:00
abstract:BACKGROUND:There is concern that antioxidant supplement use during chemotherapy and radiation therapy may decrease treatment effects, yet the effects of such supplements on recurrence and survival are largely unknown. METHODS:The authors prospectively examined the associations between antioxidant use after breast canc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26526
更新日期:2012-04-15 00:00:00
abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polym...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25938
更新日期:2011-08-15 00:00:00
abstract:BACKGROUND:Uterine serous carcinoma (USC) is not recognized as part of any defined hereditary cancer syndrome, and its association with hereditary breast and ovarian carcinoma and Lynch syndrome are uncertain. METHODS:Using targeted capture and massively parallel genomic sequencing, 151 subjects with USC were assessed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27720
更新日期:2013-01-15 00:00:00
abstract::The authors report a case of Stage IV, unfavorable histologic type adult nephroblastoma. The patient was treated with multimodal therapy: combination chemotherapy consisting of cyclophosphamide, doxorubicin, cisplatin, and etoposide succeeded by nephrectomy and radiation therapy. After a disease-free period of 27 mont...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920615)69:12<2990::aid-cncr282
更新日期:1992-06-15 00:00:00
abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<222::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract:BACKGROUND:In cholangiocarcinoma, no established method of analysis of lymph node metastasis has been reported with respect to the surgical outcome. METHODS:The authors retrospectively examined the pattern of lymph node metastasis and the surgical outcome with reference to the International Union Against Cancer (UICC)...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence-free survival. In the current study, the authors attempted to analyze 21 patients genetically and cli...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11322
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29259
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are a specific clinicopathologic entity characterized by activating mutations in the c-KIT gene. These mutations are associated with increased immunohistochemical staining for the c-KIT protein. Because many GISTs display a definitive response to the KIT inhibitor imat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21064
更新日期:2005-06-25 00:00:00
abstract:BACKGROUND:Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS:The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study a...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.21056
更新日期:2005-06-01 00:00:00
abstract::We have used immunohistology and radioimmunoassay procedures to study Chromogranin A (CgA) in human neuroendocrine tumor cell lines, especially small cell lung cancers (SCLC). By immunohistology, CgA could be detected in 11 of 18 classical SCLC cell lines, in a medullary thyroid carcinoma (MTC) cell line, and in only ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880701)62:1<92::aid-cncr282062
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long-term effects, especially on physical recovery, are unknown. METHODS:Longitudinal data from newly diagnosed breast cancer patients (N=100) who were married or cohabiting were used. Patients we...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.23964
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long-term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26203
更新日期:2011-12-15 00:00:00
abstract::The greatest decrease in breast cancer mortality is likely to derive from applying globally existing therapies at an earlier stage. A high priority of the World Health Organization (WHO) cancer control program is the outreach approach that promotes worldwide access to cancer therapies of proven values. Therefore, the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900615)65:12<2803::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract:BACKGROUND:A national data source for identifying patients with cancer enrolled in Medicaid is needed to evaluate cancer care for low-income, publicly insured patients. In this study, a population-based data set of patients diagnosed with cancer and enrolled in Medicaid was created and evaluated. The objective was to c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33207
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Hepatic artery administration of iodine-131-Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocellular carcinoma. Its efficacy has been promising according to trials conducted in the adjuvant setting after hepatic resection. Further investigation of its role in the palliative se...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25283
更新日期:2010-09-01 00:00:00
abstract::Karyotypes from seven patients with thyroid lymphoma were studied before treatment. When the cytogenetic results were correlated with the clinical data, it became evident that there are two distinct groups of patients with thyroid lymphoma. In a group of patients with solely numerical abnormalities the disease is asso...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890301)63:5<873::aid-cncr28206
更新日期:1989-03-01 00:00:00
abstract::The diagnosis and grading of chondrosarcoma of bone is best established by a complementary study of its cytology, as observed in smeared preparations, and of its tissue structure and relationship to the host bone, as observed in histologic sections. Smeared preparations demonstrate the cytologic features of chondrosar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<582::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract::Sixty-three gastrectomy specimens (21 with early intestinal type carcinoma, 21 with early diffuse carcinoma, and 21 with benign nonneoplastic lesions) were examined histochemically to determine the distribution of intestinal metaplasia (IM), particularly the sulphomucin-secreting type (Type IIB IM). The frequency and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900815)66:4<689::aid-cncr28206
更新日期:1990-08-15 00:00:00
abstract::Eighty-one female patients with phyllodes tumors of the breast, surgically treated from 1974 to 1983, were studied. Their age ranged from 9 to 88 years. According to histology, the series was divided into three groups, of 28 (34.5%) benign tumors, 32 (39.5%) border-line tumors, and 21 (25.9%) malignant tumors. Because...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2532::aid-cncr282
更新日期:1989-06-15 00:00:00