Demonstration of Chromogranin A in human neuroendocrine cell lines by immunohistology and immunoassay.

Abstract:

:We have used immunohistology and radioimmunoassay procedures to study Chromogranin A (CgA) in human neuroendocrine tumor cell lines, especially small cell lung cancers (SCLC). By immunohistology, CgA could be detected in 11 of 18 classical SCLC cell lines, in a medullary thyroid carcinoma (MTC) cell line, and in only one of 13 variant- or non-SCLC cell lines. By radioimmunoassay, CgA could be detected in the cells and culture media of all of the classical SCLC cell lines tested. Many of the classical SCLC cell lines also produced calcitonin (CT). These studies demonstrate that CgA production is a common feature of SCLC cell lines, especially those with neuroendocrine characteristics.

journal_name

Cancer

journal_title

Cancer

authors

Deftos LJ,Linnoila RI,Carney DN,Burton DW,Leong SS,O'Connor DT,Murray SS,Gazdar AF

doi

10.1002/1097-0142(19880701)62:1<92::aid-cncr282062

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

92-7

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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