Abstract:
:We have used immunohistology and radioimmunoassay procedures to study Chromogranin A (CgA) in human neuroendocrine tumor cell lines, especially small cell lung cancers (SCLC). By immunohistology, CgA could be detected in 11 of 18 classical SCLC cell lines, in a medullary thyroid carcinoma (MTC) cell line, and in only one of 13 variant- or non-SCLC cell lines. By radioimmunoassay, CgA could be detected in the cells and culture media of all of the classical SCLC cell lines tested. Many of the classical SCLC cell lines also produced calcitonin (CT). These studies demonstrate that CgA production is a common feature of SCLC cell lines, especially those with neuroendocrine characteristics.
journal_name
Cancerjournal_title
Cancerauthors
Deftos LJ,Linnoila RI,Carney DN,Burton DW,Leong SS,O'Connor DT,Murray SS,Gazdar AFdoi
10.1002/1097-0142(19880701)62:1<92::aid-cncr282062subject
Has Abstractpub_date
1988-07-01 00:00:00pages
92-7issue
1eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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