Abstract:
:Immunomorphologic methods were utilized to localize adenosine deaminase (ADA) in extrathymic benign lymphoid tissues and B-cell lymphomas. In reactive lymph nodes, tonsils and appendix, germinal centers displayed strong ADA-positive nuclear staining in small cleaved lymphocytes and weak nuclear and/or cytoplasmic staining in large lymphoid cells. A significant proportion of ADA-positive lymphocytes in the germinal centers were B-cells. The mantle zone of secondary follicles did not stain for ADA. The plasma cells in the medullary cords demonstrated mainly cytoplasmic staining. In the spleen, ADA-positive lymphocytes were located in the periarteriolar sheath and paratrabecular white pulp. In lymphoma B-cells, patterns of ADA staining were similar to those observed in normal B-lymphocytes of similar morphology. This study demonstrated that human normal and lymphoma B-lymphoid cells are heterogeneous with respect to ADA expression. This heterogeneity appears to be associated with differentiation and/or proliferation of B-lymphocytes.
journal_name
Cancerjournal_title
Cancerauthors
Chechik BE,Schrader WP,Perets A,Fernandes Bdoi
10.1002/1097-0142(19840101)53:1<70::aid-cncr282053subject
Has Abstractpub_date
1984-01-01 00:00:00pages
70-8issue
1eissn
0008-543Xissn
1097-0142journal_volume
53pub_type
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