Abstract:
:Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing masses. A needle aspirate of retrobulbar space confirmed the diagnosis of extramedullary hematopoiesis. The patient subsequently developed a rapidly worsening tumor-like syndrome with hemiparesis, aphasia, and loss of sphinteric control. The administration of radiotherapy caused a complete and stable regression of clinical symptoms and a marked reduction of MM masses.
journal_name
Cancerjournal_title
Cancerauthors
Landolfi R,Colosimo C Jr,De Candia E,Castellana MA,De Cristofaro R,Trodella L,Leone Gdoi
10.1002/1097-0142(19881201)62:11<2346::aid-cncr282subject
Has Abstractpub_date
1988-12-01 00:00:00pages
2346-9issue
11eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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