Abstract:
:Forty seven patients with early gastric cancer received a 30-minute intravenous injection of bromodeoxyuridine (BrdU), 1000 mg each 1 hour before laparotomy, to label tumor cells in the S phase. In 13 of 47 patients, specimens obtained by endoscopic biopsy were cultured in vitro at 37 degrees C for 1 hour under three times the atmospheric pressure in a vial with 400 microM BrdU. Labeled cells were detected in the resected specimen and the cultured specimen by immunohistochemical staining procedure. The BrdU labeling index (LI, defined as the percentage of labeled cells in relation to the 1000 tumor cells) was calculated for each specimen. All patients without lymph node metastasis had an in vivo BrdU LI of less than 12%. In contrast, 31% of patients with early gastric cancer with an in vivo BrdU LI greater than 12% had lymph node metastasis. There was a correlation between the in vivo and the in vitro LI. Therefore, the in vitro BrdU LI of specimens obtained by endoscopic biopsy may be a useful indicator of lymph node status in patients with individual early gastric cancers before operations. If the in vitro BrdU LI is less than 12% lymph node dissection may not be necessary.
journal_name
Cancerjournal_title
Cancerauthors
Kamata T,Yonemura Y,Sugiyama K,Ooyama S,Kosaka T,Yamaguchi A,Miwa K,Miyazaki Idoi
10.1002/1097-0142(19891015)64:8<1665::aid-cncr2820subject
Has Abstractpub_date
1989-10-15 00:00:00pages
1665-8issue
8eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
杂志文章相关文献
CANCER文献大全abstract::Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma consti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<164::aid-cncr28206
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS:The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study a...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.21056
更新日期:2005-06-01 00:00:00
abstract::Two children with Wilms' tumor and prior thoracic radiation developed congestive heart failure at cumulative adriamycin doses of 350 mg/m2 and 400 mg/m2. Details of these two cases and a summary of previously reported adriamycin cardiotoxicity in children are presented. Dose recommendations and predictive tests are di...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197701)39:1<62::aid-cncr28203901
更新日期:1977-01-01 00:00:00
abstract::Antibodies to herpes simplex viral-induced antigens (HSVIA) were assayed by an indirect immunofluorescent technique in 93 regular cigarette smokers, 75 of whom also imbibed alcoholic beverages. Controls were 94 nonsmoking, nondrinking volunteers matched with the smoker for age and sex. IgA antibodies to HSVIA were det...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197609)38:3<1155::aid-cncr282038
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND:Approximately 5% of clear cell renal cell carcinomas contain components with sarcomatoid differentiation. It has been suggested that the sarcomatoid elements arise from the clear cell tumors as a consequence of clonal expansions of neoplastic cells with progressively more genetic alterations. Analysis of the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21288
更新日期:2005-09-15 00:00:00
abstract::Fifty-nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty-eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12-1.97). In 90% of all tumors the DNA index w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900415)65:8<1825::aid-cncr2820
更新日期:1990-04-15 00:00:00
abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract:BACKGROUND:Because carcinomas of unknown primary origin are highly malignant tumors with a bad prognosis (median survival, 6-12 months) and no current optimal therapy, the authors designed a prospective dose-dense chemotherapy regimen with the objective of improving the results observed in patients who receive conventi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10264
更新日期:2002-02-01 00:00:00
abstract::The authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. Southern blot hybridization was also performed in 23 cases to study their association with Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (H...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<1954::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract::The medical records of 113 patients treated with radiation therapy for invasive cervical cancer between 1975 and 1985 were retrospectively reviewed. Patients with thrombocytosis (platelet count greater than 400,000/microliters) were compared with those with normal platelet counts. Thrombocytosis was present at the ini...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920615)69:12<2975::aid-cncr282
更新日期:1992-06-15 00:00:00
abstract:BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20884
更新日期:2005-03-15 00:00:00
abstract::Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830501)51:9<1750::aid-cncr2820
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Despite significant advances in understanding the biology of renal cell carcinoma (RCC) during the past decade, metastatic disease remains nearly incurable and a major medical challenge. Because RCC is known to be immunogenic, immunotherapeutic agents such as recombinant human interleukin-2 (rIL-2) and inter...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971001)80:7<1198::aid-cn
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Systemic, high-dose interferon-alpha treatment given three times per week subcutaneously induces tumor regression in approximately 30% of patients with inoperable hepatocellular carcinoma (HCC). The objective of the current study was to determine the efficacy and safety of transcatheter arterial interferon e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11400
更新日期:2003-06-01 00:00:00
abstract::The relationship between cytogenetic findings and prognosis in 51 pediatric patients with neuroblastoma is described. Patients were classified into the following four groups based on karyotypic findings: (1) near diploidy, 42 to 47 chromosomes (n = 11); (2) hyperdiploidy, 50 to 56 chromosomes (n = 4); (3) near triploi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890101)63:1<126::aid-cncr28206
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Brain metastases from soft tissue sarcoma (STS) are uncommon. To the authors' knowledge limited information is available regarding the influence of the initial STS site, the significance of parenchymal versus leptomeningeal metastases, and the role of surgical resection. METHODS:STS patients evaluated betwe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10554
更新日期:2002-05-15 00:00:00
abstract::Combined teletherapy and interstitial iridium 192 implantation can control locally advanced breast cancer in a consistent fashion without causing significant morbidity. Moreover, in the absence of clinically evident distant metastases, patients who undergo this treatment can survive comfortably for long periods of tim...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197611)38:5<1936::aid-cncr282038
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31112
更新日期:2018-03-01 00:00:00
abstract::Between August 1978 and November 1981, 33 boys with acute lymphocytic leukemia (ALL) (26 non-T, 7 T-cell) younger than 16 years underwent bilateral wedge testicular biopsies at the time of initial diagnosis. Seven (4 non-T, 3 T-cell) demonstrated focal leukemic infiltrates. Rebiopsy after successful induction therapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860301)57:5<1038::aid-cncr2820
更新日期:1986-03-01 00:00:00
abstract::The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<2105::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:Malignant cells exhibit increased glycolytic metabolism, and in many cases increased glucose transporter gene expression. The authors hypothesized that GLUT1 glucose transporter expression is increased in colorectal carcinoma, and that the degree of expression might have prognostic significance. METHODS:GLU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980701)83:1<34::aid-cncr
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11531
更新日期:2003-08-15 00:00:00
abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<561::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract::The authors estimated cancer risk among 589 patients hospitalized with Crohn's disease between 1960-1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the expected number of cancers (E) based on the age- and sex-specific cancer rates of a standard population. The authors then co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811215)48:12<2742::aid-cncr282
更新日期:1981-12-15 00:00:00
abstract::Twenty-four patients with metastatic cancer of the choroid were seen in the Department of Therapeutic Radiology, Rush-Presbyterian--St. Luke's Medical Center, Chicago, between 1964 and 1975. One fourth of the patients had involvement in both eyes, for a total of 30 eyes involved with metastatic cancer. The most common...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1981-02-15 00:00:00
abstract:BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28844
更新日期:2014-10-15 00:00:00
abstract::This article documents the study of 383 cases of lung cancer in uranium miners and presents for the first time the relationship of radioactive radon gas and cigarette smoking. There is evidence that alpha radiation from radon gas at exposure levels above 465 working level months (WLM) is a strong contributor to the de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1402::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:BRCA2 gene, located at chromosome 13q12.3, frequently is altered in familial types of cancer in which a "double-hit" inactivation model seems to occur. In contrast, in sporadic forms of cancer there is frequent absence of a second event (point mutations) suggesting that allelic imbalance at the BRCA2 locus m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001101)89:9<1933::aid-cncr9>3.
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Several studies have recently reported on the importance of quality of life (QOL) in predicting the survival of patients with lung carcinoma. To confirm these reports, the relationship between survival and QOL, as measured by the European Organization for Research and Treatment of Cancer (EORTC) Quality of L...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19990115)85:2<333::aid-cnc
更新日期:1999-01-15 00:00:00
abstract::A total of 1026 patients with gastric cancer was followed up for five years after surgery and classified into different groups according to surgeons' assessment of nodal involvement, serosal invasion, peritoneal spread, and hepatic metastasis. The survival of each group was studied by parametric analysis, using the lo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12<2709::aid-cncr282
更新日期:1980-12-15 00:00:00