Abstract:
BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients unselected for breast carcinoma risk and then was repeated after 2-14 months (median, 8 months) if the initial lavage was classified as atypical. Breast magnetic resonance images (MRIs) were obtained from a subset of patients who had atypical lavage results. RESULTS:Marked atypia was diagnosed in 22% of 36 breasts with an incident carcinoma compared with 7% of 172 unaffected breasts (P = 0.01). After excluding breasts with an incident carcinoma, there were 32 patients (30%) with either mild or marked atypia. The lavage was repeated in 23 of these women, and the second lavage was classified as atypical in 48%. Neither marked atypia on the initial lavage nor a 5-year Gail risk > or = 1.7% predicted atypia on repeat lavage, but there was a trend for improved reproducibility when the atypia initially was diagnosed in a fluid-producing duct. MRIs were abnormal in 13% of 24 breasts with an atypical lavage, and ductal carcinoma in situ was diagnosed subsequently in 1 breast. CONCLUSIONS:Atypia frequently is diagnosed by NDL, but the reproducibility of repeat lavage is low. Lavage atypia may be physiologic or artifactual rather than pathologic in many instances. Marked atypia occasionally may represent mammographically occult ductal carcinoma in situ.
journal_name
Cancerjournal_title
Cancerauthors
Johnson-Maddux A,Ashfaq R,Cler L,Naftalis E,Leitch AM,Hoover S,Euhus DMdoi
10.1002/cncr.20884subject
Has Abstractpub_date
2005-03-15 00:00:00pages
1129-36issue
6eissn
0008-543Xissn
1097-0142journal_volume
103pub_type
杂志文章相关文献
CANCER文献大全abstract::It was shown previously that invasive human transitional cell carcinoma cell line EJ, but not the noninvasive RT4 cells, can degrade basement membrane laminin and that the degradation of basement membrane laminin was a result of a redistribution of activated cysteine proteinase cathepsin B to the plasma membrane of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820690524
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:: Histologic parameters of melanoma deposits in sentinel lymph nodes (SLNs) have been shown to be predictive of clinical outcome and the presence or absence of tumor in non-SLNs, but assessment of these parameters is prone to interobserver variation. METHODS:: Histologic sections of 44 SLNs containing metas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24298
更新日期:2009-11-01 00:00:00
abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers. METHODS:Medical records from patients (n = 155) who had PLS from 1993 to 2010 were reviewe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26195
更新日期:2011-12-01 00:00:00
abstract::The plasma levels of the immunoglobulins IgA, IgG and IgM have been measured in 55 patients with benign breast disease, 28, 68 and 22 patients with early breast cancer one day before, 10-14 days after and three-six months after mastectomy, respectively, and 35 normal healthy control women. The mean levels of IgA, IgG ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2190::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract::Surgical removal of bulky metastases of non-seminomatous germ-cell testicular cancer has been advocated as an adjuvant to chemotherapy in patients whose disease probably is too extensive to be cured by chemotherapy or surgery alone. However, in 8 of our patients, cytoreductive surgery was followed by a sudden and dram...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1498::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract::A case of coexisting lymphangiosarcoma and Kaposi's sarcoma that occurred in a female renal transplant recipient is presented. Both sarcomas were localized to the skin and were slowly progressive over several years. The coexistence of these two sarcomas may indicate that they arose from a common precursor endothelial ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911115)68:10<2330::aid-cncr282
更新日期:1991-11-15 00:00:00
abstract:BACKGROUND:Chemotherapy is known to cure a small minority of patients with acute myeloid leukemia (AML). Less is known about the risk of such patients developing subsequent cancers or about their ability to return to work. METHODS:The authors analyzed outcomes among 1892 patients who received treatment for newly diagn...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11+<2176::aid-
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Renal medullary carcinoma is a rare tumor that is most common in young black men with sickle cell disease or trait. Patients often present with advanced disease at the time of diagnosis, and their prognosis is poor, even with aggressive therapy. The clinical and pathologic features of renal medullary carcino...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20764
更新日期:2005-02-25 00:00:00
abstract::To evaluate the incidence of thrombocytopenia and bleeding among patients with solid tumors treated intensively with chemotherapy, the records of 1274 patients treated between 1972 and 1980 on protocols known to produce significant myelosuppression were reviewed. Three hundred one patients with solid tumors (breast, l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840201)53:3<557::aid-cncr28205
更新日期:1984-02-01 00:00:00
abstract::Treatment choices for localized prostate cancer appear to vary widely, although it is unclear whether this variation is a result of patient values or other factors. The authors conducted a systematic review of the literature, identifying 70 articles that focused on prostate cancer decision making. Studies suggest that...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21822
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25961
更新日期:2011-08-15 00:00:00
abstract::The urinary excretion of nonesterified cholesterol (NEC) in 170 women with cervical and endometrial carcinomas has been investigated. Control patients (236) included: 1) women with other types of (benign and/or malignant diseases of the pelvic organs; 2) patients with non-steroid-related neoplasms; 3) patients with be...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197510)36:4<1459::aid-cncr282036
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer. METHODS:Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24192
更新日期:2009-04-15 00:00:00
abstract::The authors have shown previously that bone marrow transplant (BMT) patients who self-administered bolus doses of morphine gained equal oral mucositis pain relief while using less drug compared with similar patients receiving morphine by staff-controlled continuous infusion. In a follow-up study they compared the effi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910215)67:4<873::aid-cncr28206
更新日期:1991-02-15 00:00:00
abstract:BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1092::aid-cncr1425
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Previous studies have indicated that the incidence and mortality rates for multiple myeloma have increased in the United States. The authors reported on the incidence of multiple myeloma in Olmsted County, Minnesota, between 1991 and 2001 and on trends in multiple myeloma incidence over the last 56 years. M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20652
更新日期:2004-12-01 00:00:00
abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.2820741314
更新日期:1994-07-01 00:00:00
abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:The health-related functioning of patients with cancer is compromised by several factors, including the disease process, treatment, and the various symptoms that are produced by both disease and treatment. This study was designed to specify the relationship between patients' pain severity and their self-repo...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:There is good prognostic correlation for the two microstaging systems, Breslow depth and Clark level, commonly used to stage melanomas. Many investigators have reported that Breslow depth is the superior microstaging method. Although Clark level has been dropped from most of the proposed American Joint Commi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::Long-term vocational achievements of 40 survivors of cancer diagnosed during adolescence were examined and compared with 40 healthy sex-matched and age-matched controls. Patients' ages at diagnosis ranged from 13 to 19 years (mean, 16.15). Study subjects had survived cancer for over 5 years and were on no cancer thera...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890101)63:1<213::aid-cncr28206
更新日期:1989-01-01 00:00:00
abstract::Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...
journal_title:Cancer
pub_type: 杂志文章,收录出版,评审
doi:10.1002/cncr.24236
更新日期:2009-05-15 00:00:00
abstract::This report identifies five general conclusions that emerged from the Second Workshop on Methodology in Behavioral and Psychosocial Cancer Research. These conclusions address diverse topics, including a focus on areas other than methodology; an emphasis on the transfer of technology and knowledge to applied settings; ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910201)67:3+<865::aid-cncr2820
更新日期:1991-02-01 00:00:00
abstract::The body composition of 23 patients with cachexia resulting from malignant or benign inflammatory disease was studied. Skinfold thickness and radioisotope tracer measurements enabled us to estimate total body fat, lean body mass, the ratio of fat loss to lean body loss, erythrocyte and plasma volumes, total body water...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801101)46:9<2041::aid-cncr2820
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:The effectiveness of adjuvant chemotherapy in soft tissue sarcomas remains a matter of controversy. The authors reviewed their experience with 14 patients with localized disease treated with intensive doxorubicin-cisplatin-ifosfamide-based chemotherapy. METHODS:Fourteen patients with newly diagnosed nonmeta...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19931001)72:7<2161::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract::Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197806)41:6<2420::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:Although there is no doubt that bisphosphonates (BPs), specific inhibitors of osteoclasts, are beneficial for the treatment of bone metastases, their effects on visceral metastases are unclear. The effect of zoledronic acid (ZOL) was examined in vivo on lung metastasis progression and animal survival, and in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21530
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951201)76:11<2338::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract::Therapy for acute lymphocytic leukemia (ALL) has been less successful in adults than in children. Many centers treat all adult leukemia with the same regimen. We have used vincristine and prednisone for initial therapy in 14 adults with ALL since 1971 and have followed a treatment regimen developed for childhood ALL f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<672::aid-cncr2820380
更新日期:1976-08-01 00:00:00