Humoral immunity to herpes simplex viral-induced antigens in smokers.

Abstract:

:Antibodies to herpes simplex viral-induced antigens (HSVIA) were assayed by an indirect immunofluorescent technique in 93 regular cigarette smokers, 75 of whom also imbibed alcoholic beverages. Controls were 94 nonsmoking, nondrinking volunteers matched with the smoker for age and sex. IgA antibodies to HSVIA were detected six times more frequently in the sera of smokers than in nonsmoking controls, p less than .0005. IgG and IgM anti-HSVIA were detected with comparable frequencies in both groups, but the antibody titers were significantly higher in the smoking group than in controls, p less than .05. IgA anti-HSVIA was detected more frequently in smokers with 10 or more pack-years of cigarette exposure than in smokers with 10 or more pack-years of smoking (p less than .05) or in matched nonsmokers (p less than .02). IgA antibody titers to HSVIA were significantly higher in cigarette smokers who drank alcoholic beverages than in smokers who did not drink, p less than .025. This study demonstrates that cigarette smoking and the use of alcoholic beverages are associated with heightened humoral immunity to HSV-induced antigens in a population at high risk for development of squamous cell carcinomas of the head and neck region.

journal_name

Cancer

journal_title

Cancer

authors

Smith HG,Horowitz N,Silverman NA,Henson DE,Chretien PB

doi

10.1002/1097-0142(197609)38:3<1155::aid-cncr282038

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

1155-62

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

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