Methotrexate with citrovorum factor rescue as primary therapy for gestational trophoblastic disease.

abstract：BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...

journal_title：Cancer

authors： Kantarjian HM,Jabbour EJ,Garcia-Manero G,Kadia TM,DiNardo CD,Daver NG,Borthakur G,Jain N,Waukau JB,Kwari MI,Ravandi F,Anderson BD,Iizuka K,Jin C,Zhang C,Plunkett WK

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Preoperative chemotherapy for hepatic resection of colorectal liver metastases is associated with the development of chemotherapy-associated steatohepatitis (CASH). This increases the risk of perioperative morbidity and mortality. To the authors' knowledge, an animal model for CASH has not been described pre...

journal_title：Cancer

authors： Keizman D,Maimon N,Ish-Shalom M,Buchbut D,Inbar M,Klein B,Bernheim J,Goldiner I,Leikin-Frenkel A,Konikoff F

更新日期：2010-01-01 00:00:00

abstract：:Many clinicians use group support to reduce the psychosocial difficulties of persons with cancer. This study compared the long-term benefits of a thematic counseling model used both as a structure for group support and for counseling patients individually. The thematic model included eight counseling sessions focused ...

journal_title：Cancer

authors： Cain EN,Kohorn EI,Quinlan DM,Latimer K,Schwartz PE

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Whereas the role of specific symptoms, such as pain and fatigue, for quality of life (QOL) is unquestioned, their relative importance for long-lasting impairments in QOL in cancer patients has rarely been assessed quantitatively. The authors, therefore, aimed to identify symptoms most predictive of limitatio...

journal_title：Cancer

authors： Arndt V,Stegmaier C,Ziegler H,Brenner H

更新日期：2006-11-15 00:00:00

abstract：BACKGROUND:Metastases to the breast from extramammary primary tumors are uncommon. Malignant melanoma is one of the most common neoplasms to secondarily involve the mammary parenchyma. METHODS:Seven cases of malignant melanoma metastatic to the breast diagnosed by fine-needle aspiration biopsy are presented. RESULTS:...

journal_title：Cancer

authors： Cangiarella J,Symmans WF,Cohen JM,Goldenberg A,Shapiro RL,Waisman J

更新日期：1998-06-25 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the efficacy of adding chronic, intermittent, low-dose vinorelbine to gefitinib treatment for patients who had adenocarcinoma of the lung who failed>or=2 regimens of chemotherapy. METHODS:Patients were randomized into 2 arms: Oral gefitinib 250 mg daily (the G arm) ...

journal_title：Cancer

authors： Chen YM,Liu JM,Chou TY,Perng RP,Tsai CM,Whang-Peng J

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...

journal_title：Cancer

authors： Adelstein DJ,Rice TW,Becker M,Larto MA,Kirby TJ,Koka A,Tefft M,Zuccaro G

更新日期：1997-09-15 00:00:00

abstract：BACKGROUND:Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS:Sixty-two patients with Stage IB-IV gastric/gastroesophageal a...

journal_title：Cancer

authors： Cheng JC,Liu MC,Tsai SY,Fang WT,Jer-Min Jian J,Sung JL

更新日期：2004-11-01 00:00:00

abstract：:With nearly 80% of childhood cancer patients achieving cure, there are more adult survivors living now than at any other time in history. Because they are at risk for developing complications of treatment years later, it is recommended that survivors undergo systematic, regular monitoring into young adulthood and beyo...

journal_title：Cancer

authors： Freyer DR,Kibrick-Lazear R

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Current techniques to define gastric neoplasia are limited but molecular genetic signatures can categorize tumors and provide biological rationale for predicting clinical behavior. We identified three gene signatures: Chromogranin A (CgA), MAGE-D2 (adhesion), and MTA1 (metastasis) that define gastrointestina...

journal_title：Cancer

authors： Kidd M,Modlin IM,Mane SM,Camp RL,Eick GN,Latich I,Zikusoka MN

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with...

journal_title：Cancer

authors： Kao CH,Shiau YC,Shen YY,Yen RF

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Screening over many years is required to optimize reductions in colorectal cancer (CRC) mortality. However, no prior trials have compared strategies for obtaining long-term adherence. METHODS:Systems of Support to Increase Colorectal Cancer Screening and Follow-Up was implemented in an integrated health car...

journal_title：Cancer

authors： Green BB,Anderson ML,Cook AJ,Chubak J,Fuller S,Meenan RT,Vernon SW

更新日期：2017-11-15 00:00:00

abstract：:Results of cytogenetic studies of a patient with acute granulocytic leukemia are described. The modal number of chromosomes in cells from bone marrow samples was 43; the karyotype was characterized by missing chromosomes in groups B, C, and E. According to successive studies of the same metaphases by fluorescent stain...

journal_title：Cancer

authors： Sofuni T,Okada H

更新日期：1975-02-01 00:00:00

abstract：:Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (...

journal_title：Cancer

authors： Schneider A,Kemeny N,Chapman D,Niedzwiecki D,Oderman P

更新日期：1989-12-01 00:00:00

abstract：:Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lowe...

journal_title：Cancer

authors： Mangan C,Jeglum KA,Sedlacek TV,Giuntoli RL,Wheeler JE,Rubin E,Mikuta JJ

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS:Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates ...

journal_title：Cancer

authors： O'Malley CD,Prehn AW,Shema SJ,Glaser SL

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (IMRT) or conventional radiotherapy (CRT). METHODS:Forty-six patients who received definitive chemor...

journal_title：Cancer

authors： Bazan JG,Hara W,Hsu A,Kunz PA,Ford J,Fisher GA,Welton ML,Shelton A,Kapp DS,Koong AC,Goodman KA,Chang DT

更新日期：2011-08-01 00:00:00

abstract：:The existing system for solid tumor evaluation is criticized and revised criteria are proposed. The foundation for this analysis is a tumor stimulation experiment to determine the distribution associated with measurement of solid tumors. This tumor simulation experiment was conducted among 26 oncologists in order to a...

journal_title：Cancer

authors： Lavin PT,Flowerdew G

更新日期：1980-09-01 00:00:00

abstract：:The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...

journal_title：Cancer

authors： Brooks WH,Roszman TL,Rogers AS

更新日期：1976-04-01 00:00:00

abstract：:Breast cancer tissue from 12 male patients was evaluated for the presence of estrogen receptors (ER), and at least 10 of 12 were found to be high in ER (ER+). A combination of previously published cases and our own experience indicates that 80% of patients (37/47) have ER+ tumors. This incidence of ER positivity in me...

journal_title：Cancer

authors： Friedman MA,Hoffman PG Jr,Dandolos EM,Lagios MD,Johnston WH,Siiteri PK

更新日期：1981-01-01 00:00:00

abstract：:A short-term differential staining cytotoxicity (DiSC) assay was used to assess the sensitivity of tumor cells in vitro from patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma to various cytotoxic drugs. The results have been correlated with drug sensitivities of the tumors in vivo. The chemos...

journal_title：Cancer

authors： Bird MC,Bosanquet AG,Forskitt S,Gilby ED

更新日期：1988-03-15 00:00:00

abstract：BACKGROUND:Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. METHODS:The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. RESULTS:Histologically, the tumors were com...

journal_title：Cancer

authors： Padmore RF,Lara JF,Ackerman DJ,Gales T,Sigurdson ER,Ehya H,Cooper HS,Patchefsky AS

更新日期：1996-12-15 00:00:00

abstract：:The risk of endometrial cancer in relation to nutrition and frequency of consumption of a few selected dietary items was evaluated in a case-control study of 206 patients with endometrial cancer and 206 control subjects with acute conditions unrelated to any of the established or potential risk factors for endometrial...

journal_title：Cancer

authors： La Vecchia C,Decarli A,Fasoli M,Gentile A

更新日期：1986-03-15 00:00:00

abstract：:A 26-year-old man with erythroleukemia was found to have circulating micromegakaryocytes . Megakaryocytic features were defined by morphologic and cytochemical studies using light and electron microscopy with platelet-megakaryocyte peroxidase staining. This appears to be the first reported instance of erythroleukemia ...

journal_title：Cancer

authors： Yamauchi K,Miyauchi J,Nagao T

更新日期：1984-06-15 00:00:00

abstract：BACKGROUND:During the last decade, an inverse stage migration has been observed in radical prostatectomy series at tertiary centers. However, it remains unclear whether similar trends can also be observed in solely robotic practices, including nonreferral centers. The aim of this study was to investigate the clinical a...

journal_title：Cancer

authors： Albisinni S,Joniau S,Quackels T,De Coster G,Dekuyper P,Van Cleynenbreugel B,Van Damme N,Van Eycken E,Ameye F,Roumeguère T,Be-RALP Registry (Belgian Robotic-Assisted Laparoscopic Prostatectomy Registry).

更新日期：2017-11-01 00:00:00

abstract：:In order to validate xenografted small cell lung carcinomas (SCLC) for biological studies, the authors established 12 lung neuroendocrine (NE) tumors (eight typical SCLC and four atypical NE tumors [ANE]) by heterotransplantation onto nude mice. Their characterization was performed using serial ultrastructural, enzyma...

journal_title：Cancer

authors： Brambilla E,Jacrot M,Batandier C,Brichon PY,Morel F,Nagy-Mignotte H,Paramelle B,Brambilla C

更新日期：1989-09-15 00:00:00

abstract：:The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...

journal_title：Cancer

authors： Burgers JM,van Glabbeke M,Busson A,Cohen P,Mazabraud AR,Abbatucci JS,Kalifa C,Tubiana M,Lemerle JS,Voûte PA

更新日期：1988-03-01 00:00:00

abstract：:Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistical...

journal_title：Cancer

authors： Rose DP,Davis TE

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Multiple lymphomatous polyposis (MLP) results from gastrointestinal involvement by a B-cell lymphoma that originates from the mantle zone of lymphoid follicles. This well described clinicopathologic entity has a poor prognosis: the rate of complete response after conventional chemotherapy is very low. High d...

journal_title：Cancer

authors： Mahé B,Moreau A,Moreau P,Le Tortorec S,Harousseau JL,Milpied N

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:The Danish Breast Cancer Cooperative Group (DBCG) 77B trial examined the relative efficacy of levamisole, single-agent oral cyclophosphamide, and the classic combination of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) against no adjuvant systemic therapy in high-risk breast cancer patients. The a...

journal_title：Cancer

authors： Ejlertsen B,Mouridsen HT,Jensen MB,Andersen J,Andersson M,Kamby C,Knoop AS,Danish Breast Cancer Cooperative Group.

更新日期：2010-05-01 00:00:00