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Current trends in patient enrollment for robotic-assisted laparoscopic prostatectomy in Belgium.

Abstract：

BACKGROUND:During the last decade, an inverse stage migration has been observed in radical prostatectomy series at tertiary centers. However, it remains unclear whether similar trends can also be observed in solely robotic practices, including nonreferral centers. The aim of this study was to investigate the clinical and pathological trends in robotic-assisted laparoscopic prostatectomy (RALP) enrollment in Belgium over a period of 6 years through an analysis of a prospective registry. METHODS:A prospective, multicenter database was constructed: consecutive patients undergoing RALP in Belgium from 2010 to 2015 were enrolled, and 7366 men were analyzed. Variations in clinical and pathological variables were explored as a function of the enrollment year with proportional odds for categorical variables and with linear regressions for continuous variables. RESULTS:Net increases were observed in the prostate-specific antigen levels, cT stage, and biopsy Gleason scores across the study years (P < .001). The rate of low-risk prostate cancer (PCa) decreased from 36% in 2010 to 21% in 2015, whereas the rate of intermediate-risk PCa rose from 47% to 58%, and the rate of high-risk PCa rose from 17% to 21%. In parallel, the pT2 stage rate decreased from 76% to 64%, and the rate of Gleason 6 (3 + 3) cases was reduced from 45% to 23% (P < .001). Conversely, the pT3a stage rate rose from 16% to 24%, the pT3b stage rate rose from 7% to 11%, and the rate of Gleason 7 (4 + 3) cases rose from 7% to 21% (P < .0001). Finally, more patients underwent node dissection, and positive lymph nodes were increasingly diagnosed (from 3% in 2010 to 7% in 2015). CONCLUSIONS:During the last 6 years of RALP implementation in Belgium, there was a significant increase in the enrollment of intermediate- and high-risk PCa patients. This yielded a significant increase in adverse pathological characteristics. These results suggest a paradigm shift in PCa treatment, with radical robotic surgery increasing for intermediate- and high-risk patients. Cancer 2017;123:4139-4146. © 2017 American Cancer Society.

journal_name

Cancer

journal_title

Cancer

authors

Albisinni S,Joniau S,Quackels T,De Coster G,Dekuyper P,Van Cleynenbreugel B,Van Damme N,Van Eycken E,Ameye F,Roumeguère T,Be-RALP Registry (Belgian Robotic-Assisted Laparoscopic Prostatectomy Registry).

doi

10.1002/cncr.30874

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

4139-4146

issue

eissn

0008-543X

issn

1097-0142

journal_volume

123

pub_type

杂志文章,多中心研究

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Current trends in patient enrollment for robotic-assisted laparoscopic prostatectomy in Belgium.